Best TWAS P=2.09e-09 · Best GWAS P=1.68e-08 conditioned to 0.402
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PRMT6 | 0.19 | 0.16 | lasso | 6 | 0.16 | 5.4e-19 | 5.4 | -5.5 | 4.2e-08 | -0.88 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | PRMT6 | 0.17 | 0.10 | enet | 6 | 0.11 | 5.1e-09 | 5.6 | -5.7 | 1.2e-08 | -0.96 | 0.01 | 0.99 | FALSE |
3 | GTEx | Colon Transverse | PRMT6 | 0.29 | 0.24 | lasso | 7 | 0.19 | 1.4e-09 | 5.4 | -5.7 | 1.3e-08 | -0.90 | 0.01 | 0.99 | FALSE |
4 | GTEx | Esophagus Mucosa | PRMT6 | 0.33 | 0.23 | lasso | 7 | 0.29 | 1.4e-19 | 5.5 | -5.6 | 2.0e-08 | -0.93 | 0.01 | 0.99 | FALSE |
5 | GTEx | Heart Left Ventricle | PRMT6 | 0.16 | 0.12 | enet | 9 | 0.13 | 2.3e-07 | 5.4 | -5.4 | 6.1e-08 | -0.83 | 0.01 | 0.99 | FALSE |
6 | GTEx | Liver | PRMT6 | 0.60 | 0.52 | lasso | 6 | 0.58 | 1.0e-19 | 5.4 | -5.6 | 1.8e-08 | -0.88 | 0.01 | 0.99 | FALSE |
7 | GTEx | Lung | PRMT6 | 0.11 | 0.14 | lasso | 2 | 0.13 | 2.2e-10 | 5.5 | -5.5 | 4.5e-08 | -0.88 | 0.01 | 0.99 | FALSE |
8 | GTEx | Muscle Skeletal | PRMT6 | 0.32 | 0.16 | enet | 13 | 0.16 | 2.8e-15 | 5.5 | -6.0 | 2.1e-09 | -0.87 | 0.01 | 0.99 | TRUE |
9 | GTEx | Skin Not Sun Exposed Suprapubic | PRMT6 | 0.46 | 0.35 | lasso | 6 | 0.37 | 2.1e-21 | 5.5 | -5.5 | 4.0e-08 | -0.89 | 0.01 | 0.99 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | PRMT6 | 0.40 | 0.36 | lasso | 4 | 0.37 | 6.1e-32 | 5.5 | -5.5 | 4.5e-08 | -0.89 | 0.01 | 0.99 | FALSE |
11 | GTEx | Stomach | PRMT6 | 0.29 | 0.16 | enet | 7 | 0.15 | 8.6e-08 | 5.4 | -5.4 | 6.1e-08 | -0.92 | 0.01 | 0.99 | FALSE |
12 | GTEx | Thyroid | PRMT6 | 0.19 | 0.17 | enet | 14 | 0.19 | 1.7e-14 | 5.4 | -5.6 | 2.2e-08 | -0.88 | 0.01 | 0.99 | FALSE |
13 | METSIM | Adipose | PRMT6 | 0.21 | 0.20 | lasso | 9 | 0.21 | 1.1e-30 | 5.4 | -5.5 | 3.7e-08 | -0.89 | 0.01 | 0.99 | FALSE |
14 | YFS | Blood | PRMT6 | 0.32 | 0.34 | enet | 28 | 0.36 | 6.6e-123 | 5.5 | -5.2 | 2.0e-07 | -0.89 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRMT6 | 0.13 | 0.10 | lasso | 4 | 0.10 | 2.0e-08 | 5.4 | -5.6 | 1.8e-08 | -0.89 | 0.01 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PRMT6 | 0.10 | 0.15 | lasso | 3 | 0.16 | 1.2e-30 | 5.4 | -5.5 | 4.8e-08 | -0.89 | 0.01 | 0.99 | FALSE |
17 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PRMT6 | 0.09 | 0.03 | blup | 36 | 0.07 | 1.8e-04 | 5.4 | -5.2 | 1.5e-07 | -0.72 | 0.01 | 0.93 | FALSE |
18 | The Cancer Genome Atlas | Colon Adenocarcinoma | PRMT6 | 0.19 | 0.20 | lasso | 4 | 0.24 | 2.4e-14 | 5.5 | -5.5 | 4.6e-08 | -0.89 | 0.01 | 0.99 | FALSE |
19 | The Cancer Genome Atlas | Esophageal Carcinoma | PRMT6 | 0.33 | 0.26 | lasso | 3 | 0.25 | 2.0e-08 | 5.4 | -5.6 | 2.2e-08 | -0.88 | 0.01 | 0.99 | FALSE |
20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PRMT6 | 0.16 | 0.17 | lasso | 6 | 0.17 | 8.4e-19 | 5.5 | -5.4 | 5.4e-08 | -0.89 | 0.01 | 0.99 | FALSE |
21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PRMT6 | 0.08 | 0.11 | lasso | 4 | 0.11 | 1.1e-12 | 5.5 | -5.5 | 4.3e-08 | -0.89 | 0.01 | 0.99 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PRMT6 | 0.06 | 0.08 | lasso | 3 | 0.06 | 1.6e-04 | 5.5 | -5.5 | 4.4e-08 | -0.89 | 0.01 | 0.98 | FALSE |
23 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PRMT6 | 0.29 | 0.28 | lasso | 4 | 0.28 | 2.6e-13 | 5.4 | -5.2 | 1.5e-07 | -0.89 | 0.01 | 0.99 | FALSE |
24 | The Cancer Genome Atlas | Lung Adenocarcinoma | PRMT6 | 0.17 | 0.22 | lasso | 3 | 0.22 | 4.8e-25 | 5.4 | -5.4 | 5.2e-08 | -0.90 | 0.01 | 0.99 | FALSE |
25 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PRMT6 | 0.11 | 0.12 | enet | 7 | 0.12 | 2.3e-13 | 5.5 | -5.7 | 1.3e-08 | -0.88 | 0.01 | 0.99 | FALSE |
26 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PRMT6 | 0.09 | 0.08 | blup | 36 | 0.08 | 3.3e-06 | 5.4 | -5.9 | 3.6e-09 | -0.90 | 0.01 | 0.99 | FALSE |
27 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PRMT6 | 0.17 | 0.17 | enet | 6 | 0.19 | 1.5e-13 | 5.5 | -5.5 | 3.9e-08 | -0.89 | 0.01 | 0.99 | FALSE |