Best TWAS P=2.07e-11 · Best GWAS P=3.01e-13 conditioned to 0.645
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C3orf38 | 0.08 | 0.00 | enet | 14 | 0.04 | 2.3e-05 | -5.5 | -6.7 | 2.1e-11 | 0.56 | 0.24 | 0.58 | TRUE |
| 2 | GTEx | Artery Aorta | C3orf38 | 0.06 | 0.06 | lasso | 7 | 0.05 | 6.0e-04 | -5.7 | 5.7 | 9.5e-09 | -0.67 | 0.59 | 0.13 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | ZNF654 | 0.08 | 0.09 | enet | 6 | 0.10 | 3.1e-08 | -6.7 | -6.7 | 2.5e-11 | 0.57 | 0.10 | 0.90 | FALSE |
| 4 | GTEx | Esophagus Mucosa | C3orf38 | 0.11 | 0.06 | lasso | 7 | 0.07 | 1.5e-05 | -5.6 | 6.3 | 3.3e-10 | -0.67 | 0.51 | 0.48 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | CGGBP1 | 0.25 | 0.15 | enet | 30 | 0.16 | 1.5e-07 | -3.9 | -5.4 | 6.0e-08 | 0.60 | 0.11 | 0.80 | TRUE |
| 6 | GTEx | Nerve Tibial | C3orf38 | 0.09 | 0.05 | lasso | 4 | 0.04 | 6.3e-04 | -5.7 | 5.8 | 7.7e-09 | -0.68 | 0.50 | 0.33 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | ZNF654 | 0.09 | 0.01 | lasso | 7 | 0.06 | 2.7e-04 | -5.8 | -5.4 | 7.2e-08 | 0.64 | 0.12 | 0.16 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | C3orf38 | 0.09 | 0.07 | lasso | 6 | 0.04 | 2.8e-03 | -5.5 | 5.4 | 5.7e-08 | -0.68 | 0.38 | 0.19 | FALSE |
| 9 | GTEx | Testis | C3orf38 | 0.11 | 0.01 | enet | 12 | 0.00 | 1.9e-01 | -5.4 | 5.3 | 1.1e-07 | -0.72 | 0.10 | 0.34 | FALSE |
| 10 | GTEx | Thyroid | C3orf38 | 0.12 | 0.08 | lasso | 18 | 0.07 | 1.0e-05 | -5.5 | 5.6 | 2.4e-08 | -0.68 | 0.89 | 0.09 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C3orf38 | 0.01 | 0.01 | lasso | 3 | 0.01 | 1.2e-03 | -5.6 | 5.4 | 5.5e-08 | -0.65 | 0.05 | 0.04 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C3orf38 | 0.02 | 0.01 | blup | 24 | 0.02 | 2.0e-03 | -5.6 | 5.5 | 3.9e-08 | -0.65 | 0.07 | 0.13 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf38 | 0.02 | 0.03 | lasso | 1 | 0.03 | 1.9e-04 | -5.6 | 5.6 | 2.7e-08 | -0.69 | 0.05 | 0.46 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C3orf38 | 0.03 | 0.05 | lasso | 1 | 0.05 | 8.1e-06 | -5.6 | 5.6 | 2.7e-08 | -0.69 | 0.64 | 0.19 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | CGGBP1 | 0.30 | 0.07 | enet | 11 | 0.09 | 2.3e-09 | -7.3 | -6.3 | 2.7e-10 | 0.80 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF654 | 0.03 | 0.04 | lasso | 3 | 0.03 | 4.6e-04 | -5.5 | -5.7 | 1.5e-08 | 0.69 | 0.16 | 0.52 | FALSE |