Best TWAS P=4.37e-14 · Best GWAS P=7.02e-13 conditioned to 0.0047
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SNX19 | 0.21 | 0.21 | lasso | 6 | 0.22 | 6.7e-26 | 5.8 | -5.5 | 3.0e-08 | 0.49 | 0.98 | 0.02 | FALSE |
2 | GTEx | Adipose Subcutaneous | SNX19 | 0.21 | 0.15 | enet | 24 | 0.16 | 2.3e-13 | 5.9 | -6.8 | 1.2e-11 | 0.73 | 0.48 | 0.52 | FALSE |
3 | GTEx | Adipose Visceral Omentum | SNX19 | 0.22 | 0.10 | lasso | 7 | 0.10 | 8.0e-06 | 5.9 | -6.7 | 2.9e-11 | 0.63 | 0.20 | 0.80 | FALSE |
4 | GTEx | Adrenal Gland | SNX19 | 0.24 | 0.16 | lasso | 4 | 0.06 | 3.2e-03 | 5.7 | -6.5 | 5.7e-11 | 0.58 | 0.21 | 0.78 | FALSE |
5 | GTEx | Artery Aorta | SNX19 | 0.39 | 0.15 | lasso | 6 | 0.28 | 1.1e-15 | 5.6 | -5.6 | 1.8e-08 | 0.54 | 0.11 | 0.89 | FALSE |
6 | GTEx | Artery Aorta | RP11-890B15.3 | 0.19 | 0.01 | enet | 1 | 0.00 | 4.8e-01 | 5.6 | -5.5 | 2.8e-08 | 0.50 | 0.07 | 0.28 | FALSE |
7 | GTEx | Artery Coronary | SNX19 | 0.25 | 0.16 | lasso | 11 | 0.18 | 1.4e-06 | 5.9 | -5.8 | 9.1e-09 | 0.55 | 0.56 | 0.34 | FALSE |
8 | GTEx | Artery Tibial | SNX19 | 0.22 | 0.14 | lasso | 6 | 0.20 | 1.5e-15 | -3.3 | -5.9 | 4.0e-09 | 0.57 | 0.22 | 0.78 | FALSE |
9 | GTEx | Brain Caudate basal ganglia | SNX19 | 0.33 | 0.12 | lasso | 5 | 0.12 | 2.8e-04 | 5.9 | -7.0 | 3.5e-12 | 0.57 | 0.11 | 0.79 | FALSE |
10 | GTEx | Brain Cerebellar Hemisphere | SNX19 | 0.33 | 0.23 | lasso | 7 | 0.28 | 7.2e-08 | -2.7 | -5.1 | 3.1e-07 | 0.49 | 0.13 | 0.76 | FALSE |
11 | GTEx | Brain Cortex | SNX19 | 0.36 | 0.12 | lasso | 7 | 0.16 | 3.3e-05 | 5.5 | -6.5 | 8.8e-11 | 0.53 | 0.07 | 0.88 | FALSE |
12 | GTEx | Brain Frontal Cortex BA9 | SNX19 | 0.41 | 0.20 | lasso | 7 | 0.37 | 7.1e-11 | -6.4 | -6.9 | 5.1e-12 | 0.52 | 0.09 | 0.88 | FALSE |
13 | GTEx | Brain Hippocampus | SNX19 | 0.24 | 0.07 | enet | 17 | 0.16 | 1.8e-04 | -6.4 | -6.7 | 2.6e-11 | 0.49 | 0.09 | 0.71 | FALSE |
14 | GTEx | Brain Hypothalamus | SNX19 | 0.32 | 0.04 | lasso | 5 | 0.13 | 7.4e-04 | 6.4 | -7.5 | 4.4e-14 | 0.67 | 0.08 | 0.86 | TRUE |
15 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-890B15.3 | 0.46 | 0.16 | lasso | 7 | 0.04 | 3.9e-02 | -5.3 | -5.4 | 5.2e-08 | 0.36 | 0.10 | 0.14 | FALSE |
16 | GTEx | Brain Putamen basal ganglia | SNX19 | 0.35 | -0.01 | enet | 18 | 0.02 | 1.4e-01 | -2.2 | -5.8 | 5.2e-09 | 0.30 | 0.06 | 0.34 | FALSE |
17 | GTEx | Breast Mammary Tissue (Female) | RP11-890B15.3 | 0.17 | 0.01 | lasso | 4 | 0.02 | 1.0e-01 | 5.8 | -5.5 | 5.0e-08 | 0.56 | 0.06 | 0.19 | FALSE |
18 | GTEx | Cells EBV-transformed lymphocytes | SNX19 | 0.29 | 0.28 | lasso | 2 | 0.26 | 5.1e-09 | 5.9 | -5.9 | 3.1e-09 | 0.55 | 0.81 | 0.18 | FALSE |
19 | GTEx | Colon Sigmoid | SNX19 | 0.34 | 0.10 | lasso | 7 | 0.28 | 2.2e-10 | 5.9 | -5.4 | 5.4e-08 | 0.49 | 0.56 | 0.44 | FALSE |
20 | GTEx | Esophagus Gastroesophageal Junction | SNX19 | 0.35 | 0.07 | enet | 29 | 0.22 | 1.7e-08 | 6.1 | -5.7 | 1.5e-08 | 0.70 | 0.12 | 0.87 | FALSE |
21 | GTEx | Esophagus Muscularis | SNX19 | 0.31 | 0.18 | enet | 23 | 0.25 | 1.2e-15 | 5.7 | -6.9 | 5.4e-12 | 0.76 | 0.11 | 0.89 | FALSE |
22 | GTEx | Heart Atrial Appendage | SNX19 | 0.50 | 0.20 | enet | 32 | 0.32 | 4.9e-15 | -6.9 | -7.1 | 1.1e-12 | 0.83 | 0.02 | 0.98 | FALSE |
23 | GTEx | Heart Left Ventricle | SNX19 | 0.21 | 0.06 | lasso | 4 | 0.05 | 9.7e-04 | 5.9 | -6.7 | 1.7e-11 | 0.59 | 0.11 | 0.85 | FALSE |
24 | GTEx | Pancreas | SNX19 | 0.35 | 0.12 | enet | 19 | 0.27 | 1.2e-11 | 5.9 | -6.0 | 1.8e-09 | 0.63 | 0.12 | 0.88 | FALSE |
25 | GTEx | Pancreas | RP11-890B15.3 | 0.16 | 0.02 | lasso | 2 | 0.01 | 1.9e-01 | -7.0 | -6.9 | 4.2e-12 | 0.60 | 0.06 | 0.84 | FALSE |
26 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-890B15.3 | 0.22 | 0.13 | enet | 16 | 0.21 | 9.0e-12 | -3.3 | -5.8 | 6.0e-09 | 0.49 | 0.96 | 0.04 | FALSE |
27 | GTEx | Stomach | SNX19 | 0.39 | 0.29 | lasso | 13 | 0.27 | 2.0e-13 | 5.9 | -6.9 | 5.9e-12 | 0.70 | 0.59 | 0.41 | FALSE |
28 | GTEx | Testis | SNX19 | 0.59 | 0.25 | enet | 24 | 0.38 | 7.1e-18 | -7.0 | -6.7 | 1.6e-11 | 0.68 | 0.03 | 0.97 | FALSE |
29 | METSIM | Adipose | RP11-890B15.3 | 0.12 | 0.12 | lasso | 5 | 0.12 | 9.4e-17 | 5.8 | -5.9 | 4.6e-09 | 0.48 | 0.90 | 0.10 | FALSE |
30 | METSIM | Adipose | SNX19 | 0.16 | 0.20 | lasso | 2 | 0.20 | 1.5e-28 | 5.8 | -5.7 | 1.1e-08 | 0.54 | 0.98 | 0.02 | FALSE |
31 | NTR | Blood | SNX19 | 0.06 | 0.05 | lasso | 6 | 0.06 | 9.9e-19 | -3.4 | -5.9 | 2.9e-09 | 0.53 | 0.99 | 0.01 | FALSE |
32 | ROSMAP | Brain Pre-frontal Cortex | SNX19 | 0.41 | 0.49 | lasso | 6 | 0.51 | 2.7e-75 | 5.8 | -6.8 | 8.9e-12 | 0.61 | 0.98 | 0.02 | FALSE |
33 | The Cancer Genome Atlas | Esophageal Carcinoma | SNX19 | 0.15 | 0.08 | lasso | 6 | 0.12 | 1.4e-04 | 5.8 | -6.8 | 8.7e-12 | 0.66 | 0.21 | 0.53 | FALSE |
34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SNX19 | 0.11 | 0.19 | enet | 15 | 0.24 | 3.2e-26 | 5.8 | -6.5 | 6.9e-11 | 0.61 | 0.94 | 0.06 | FALSE |
35 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SNX19 | 0.17 | 0.20 | lasso | 6 | 0.23 | 9.8e-26 | 5.8 | -6.4 | 1.7e-10 | 0.61 | 0.91 | 0.09 | FALSE |
36 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SNX19 | 0.12 | 0.05 | blup | 98 | 0.07 | 3.0e-04 | -3.4 | -6.0 | 1.9e-09 | 0.49 | 0.22 | 0.31 | FALSE |
37 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SNX19 | 0.06 | 0.04 | blup | 100 | 0.06 | 1.3e-03 | 5.8 | -7.0 | 3.4e-12 | 0.76 | 0.05 | 0.42 | FALSE |
38 | The Cancer Genome Atlas | Thyroid Carcinoma | SNX19 | 0.24 | 0.23 | lasso | 8 | 0.32 | 2.6e-32 | -3.4 | -5.5 | 3.9e-08 | 0.52 | 1.00 | 0.00 | FALSE |