Best TWAS P=7.34e-12 · Best GWAS P=6.05e-14 conditioned to 0.000164
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | MAP2K2 | 0.20 | 0.11 | lasso | 3 | 0.13 | 3.0e-05 | -6.3 | -6.8 | 7.3e-12 | 0.71 | 0.02 | 0.85 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | PIAS4 | 0.14 | 0.12 | lasso | 6 | 0.11 | 1.6e-13 | -5.7 | -6.0 | 1.8e-09 | 0.66 | 0.99 | 0.01 | FALSE |
| 3 | YFS | Blood | MAP2K2 | 0.02 | 0.00 | blup | 373 | 0.01 | 5.9e-03 | 3.9 | 5.8 | 8.4e-09 | -0.51 | 0.09 | 0.46 | FALSE |
| 4 | YFS | Blood | PIAS4 | 0.06 | 0.02 | bslmm | 369 | 0.04 | 4.8e-14 | -5.7 | -6.0 | 1.4e-09 | 0.67 | 0.01 | 0.99 | FALSE |