Best TWAS P=6.71e-08 · Best GWAS P=9.24e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | METTL10 | 0.20 | 0.26 | lasso | 9 | 0.26 | 4.5e-31 | -5.2 | -5.1 | 2.9e-07 | 0.98 | 0.01 | 0.99 | FALSE |
2 | GTEx | Lung | METTL10 | 0.11 | 0.06 | enet | 6 | 0.05 | 1.7e-04 | -5.2 | -5.3 | 9.9e-08 | 0.96 | 0.02 | 0.97 | FALSE |
3 | GTEx | Thyroid | METTL10 | 0.19 | 0.09 | enet | 33 | 0.10 | 3.0e-08 | -5.2 | -5.2 | 1.7e-07 | 0.84 | 0.02 | 0.98 | FALSE |
4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | METTL10 | 0.09 | 0.08 | blup | 43 | 0.11 | 1.2e-09 | -5.3 | -5.1 | 2.6e-07 | 0.96 | 0.01 | 0.99 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | METTL10 | 0.06 | 0.13 | lasso | 7 | 0.13 | 1.1e-25 | -5.2 | -5.2 | 1.7e-07 | 0.99 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Colon Adenocarcinoma | METTL10 | 0.09 | 0.14 | lasso | 9 | 0.12 | 3.1e-07 | -5.1 | -5.2 | 2.1e-07 | 0.99 | 0.01 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | METTL10 | 0.10 | 0.14 | blup | 43 | 0.14 | 7.4e-16 | -5.3 | -5.4 | 6.7e-08 | 0.98 | 0.01 | 0.99 | TRUE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | METTL10 | 0.10 | 0.16 | lasso | 7 | 0.17 | 1.0e-18 | -5.3 | -5.2 | 2.3e-07 | 0.97 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | METTL10 | 0.11 | 0.08 | blup | 43 | 0.12 | 4.8e-06 | -5.1 | -5.2 | 1.9e-07 | 0.96 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | METTL10 | 0.11 | 0.19 | lasso | 6 | 0.19 | 7.3e-22 | -5.2 | -5.3 | 1.4e-07 | 1.00 | 0.01 | 0.99 | FALSE |