[Hub]/) : Traits : Arm fat mass (left) :

chr11:42,881,882-44,607,471

Best TWAS P=1.44e-21 · Best GWAS P=1.1e-21 conditioned to 0.00524

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HSD17B12 0.44 0.51 lasso 11 0.53 6.0e-76 -8.8 8.7 3.9e-18 -0.82 0.82 0.18 FALSE
2 GTEx Adipose Subcutaneous HSD17B12 0.31 0.35 lasso 5 0.37 2.8e-31 -8.7 8.8 9.6e-19 -0.83 0.90 0.10 FALSE
3 GTEx Adipose Subcutaneous RP11-613D13.5 0.10 0.11 lasso 2 0.10 8.1e-09 -8.8 8.9 6.9e-19 -0.82 0.50 0.50 FALSE
4 GTEx Adipose Visceral Omentum HSD17B12 0.28 0.25 enet 17 0.21 2.6e-11 -8.8 9.2 4.2e-20 -0.84 0.64 0.36 FALSE
5 GTEx Adipose Visceral Omentum SEC14L1P1 0.12 0.00 enet 6 0.00 3.5e-01 -4.6 -6.8 1.4e-11 0.50 0.05 0.48 FALSE
6 GTEx Adipose Visceral Omentum RP11-613D13.5 0.18 0.01 lasso 3 0.05 8.9e-04 -8.8 8.4 3.0e-17 -0.67 0.10 0.88 FALSE
7 GTEx Adrenal Gland HSD17B12 0.20 0.19 lasso 7 0.18 5.2e-07 -8.8 8.9 6.2e-19 -0.81 0.73 0.22 FALSE
8 GTEx Artery Aorta HSD17B12 0.61 0.55 lasso 9 0.59 3.4e-39 -8.8 8.5 2.3e-17 -0.81 0.87 0.13 FALSE
9 GTEx Artery Aorta RP11-613D13.5 0.31 0.27 lasso 3 0.27 3.0e-15 -8.8 8.7 3.6e-18 -0.83 0.81 0.19 FALSE
10 GTEx Artery Coronary HSD17B12 0.61 0.41 lasso 19 0.43 4.5e-16 -8.8 8.8 9.7e-19 -0.81 0.87 0.13 FALSE
11 GTEx Artery Tibial HSD17B12 0.47 0.54 lasso 5 0.59 8.9e-57 -8.8 8.8 2.0e-18 -0.82 0.83 0.17 FALSE
12 GTEx Artery Tibial RP11-613D13.5 0.17 0.18 lasso 6 0.18 2.4e-14 -8.8 9.2 5.7e-20 -0.84 0.72 0.28 FALSE
13 GTEx Brain Caudate basal ganglia HSD17B12 0.68 0.43 lasso 18 0.49 6.0e-16 -8.8 8.3 7.2e-17 -0.81 0.78 0.22 FALSE
14 GTEx Brain Caudate basal ganglia RP11-613D13.5 0.32 0.14 enet 24 0.13 1.6e-04 -8.8 6.7 2.6e-11 -0.84 0.06 0.88 FALSE
15 GTEx Brain Cerebellar Hemisphere HSD17B12 0.50 0.41 enet 33 0.29 3.0e-08 -8.8 8.0 1.5e-15 -0.82 0.61 0.38 FALSE
16 GTEx Brain Cerebellum HSD17B12 0.52 0.39 lasso 16 0.36 2.4e-11 -8.8 8.8 1.4e-18 -0.84 0.81 0.19 FALSE
17 GTEx Brain Cortex HSD17B12 0.52 0.37 lasso 9 0.40 5.4e-12 -8.8 8.8 2.1e-18 -0.83 0.57 0.43 FALSE
18 GTEx Brain Frontal Cortex BA9 HSD17B12 0.45 0.38 lasso 7 0.36 2.8e-10 -8.8 9.0 2.8e-19 -0.83 0.37 0.63 FALSE
19 GTEx Brain Hippocampus HSD17B12 0.49 0.43 lasso 6 0.41 8.9e-11 -8.8 8.9 6.1e-19 -0.82 0.23 0.77 FALSE
20 GTEx Brain Nucleus accumbens basal ganglia HSD17B12 0.41 0.27 lasso 16 0.20 4.5e-06 -8.8 8.1 6.2e-16 -0.73 0.36 0.61 FALSE
21 GTEx Brain Putamen basal ganglia HSD17B12 0.51 0.30 enet 28 0.33 1.3e-08 -8.8 8.1 8.1e-16 -0.79 0.12 0.85 FALSE
22 GTEx Breast Mammary Tissue HSD17B12 0.21 0.17 lasso 1 0.12 6.0e-07 -8.8 8.8 1.2e-18 -0.80 0.56 0.43 FALSE
23 GTEx Breast Mammary Tissue RP11-613D13.5 0.18 0.11 lasso 5 0.15 6.3e-08 -8.8 8.0 1.1e-15 -0.77 0.22 0.74 FALSE
24 GTEx Breast Mammary Tissue (Male) HSD17B12 0.48 0.34 lasso 14 0.34 1.1e-08 -8.7 8.8 1.6e-18 -0.84 0.32 0.65 FALSE
25 GTEx Cells Transformed fibroblasts HSD17B12 0.60 0.69 lasso 10 0.69 2.0e-71 -8.8 8.8 8.9e-19 -0.83 0.88 0.12 FALSE
26 GTEx Cells Transformed fibroblasts RP11-613D13.5 0.34 0.42 lasso 9 0.42 4.5e-34 -8.7 8.7 4.0e-18 -0.83 0.90 0.10 FALSE
27 GTEx Colon Sigmoid HSD17B12 0.44 0.38 lasso 8 0.37 6.7e-14 -8.8 9.0 3.2e-19 -0.83 0.81 0.19 FALSE
28 GTEx Colon Transverse HSD17B12 0.48 0.49 lasso 4 0.50 1.3e-26 -8.8 8.8 1.3e-18 -0.82 0.88 0.12 FALSE
29 GTEx Colon Transverse RP11-613D13.5 0.21 0.24 lasso 3 0.23 3.4e-11 -8.8 8.8 1.3e-18 -0.82 0.87 0.13 FALSE
30 GTEx Esophagus Gastroesophageal Junction HSD17B12 0.51 0.35 lasso 7 0.37 3.1e-14 -8.8 9.5 1.4e-21 -0.85 0.66 0.34 TRUE
31 GTEx Esophagus Mucosa HSD17B12 0.54 0.58 lasso 12 0.58 1.3e-47 -8.8 8.9 4.2e-19 -0.84 0.88 0.12 FALSE
32 GTEx Esophagus Mucosa RP11-613D13.5 0.17 0.19 lasso 6 0.18 2.5e-12 -8.7 8.9 5.3e-19 -0.86 0.49 0.51 FALSE
33 GTEx Esophagus Muscularis HSD17B12 0.57 0.56 lasso 8 0.58 1.1e-42 -8.8 8.7 5.1e-18 -0.81 0.87 0.13 FALSE
34 GTEx Esophagus Muscularis RP11-613D13.5 0.21 0.20 lasso 2 0.19 9.6e-12 -8.8 8.7 4.4e-18 -0.83 0.87 0.13 FALSE
35 GTEx Heart Atrial Appendage HSD17B12 0.52 0.46 lasso 6 0.44 1.2e-21 -8.8 8.3 1.1e-16 -0.81 0.86 0.14 FALSE
36 GTEx Heart Atrial Appendage RP11-613D13.5 0.18 0.02 enet 11 0.07 5.3e-04 -8.8 7.1 1.7e-12 -0.78 0.08 0.89 FALSE
37 GTEx Heart Left Ventricle HSD17B12 0.25 0.28 lasso 4 0.25 8.2e-14 -8.8 8.9 3.7e-19 -0.81 0.87 0.13 FALSE
38 GTEx Liver HSD17B12 0.46 0.38 enet 24 0.28 1.3e-08 -8.6 8.3 1.0e-16 -0.83 0.18 0.82 FALSE
39 GTEx Liver RP11-613D13.5 0.30 0.24 lasso 3 0.23 4.6e-07 -9.6 8.9 6.8e-19 -0.97 0.01 0.99 FALSE
40 GTEx Lung HSD17B12 0.54 0.59 enet 32 0.61 8.3e-59 -8.8 8.3 6.6e-17 -0.80 0.84 0.16 FALSE
41 GTEx Lung RP11-613D13.5 0.18 0.20 lasso 2 0.17 6.0e-13 -8.8 8.8 1.2e-18 -0.81 0.84 0.16 FALSE
42 GTEx Muscle Skeletal HSD17B12 0.35 0.38 enet 24 0.37 3.4e-38 -8.8 8.4 2.8e-17 -0.83 0.84 0.16 FALSE
43 GTEx Nerve Tibial HSD17B12 0.58 0.52 enet 56 0.56 3.5e-47 -8.8 7.7 1.5e-14 -0.80 0.88 0.12 FALSE
44 GTEx Nerve Tibial RP11-613D13.5 0.14 0.19 lasso 2 0.18 1.1e-12 -8.7 8.8 2.2e-18 -0.85 0.78 0.22 FALSE
45 GTEx Ovary HSD17B12 0.45 0.36 lasso 17 0.33 5.4e-09 -8.8 9.0 3.2e-19 -0.82 0.45 0.54 FALSE
46 GTEx Pancreas HSD17B12 0.43 0.40 lasso 2 0.40 7.6e-18 -8.8 8.9 7.7e-19 -0.80 0.84 0.16 FALSE
47 GTEx Prostate HSD17B12 0.65 0.51 enet 34 0.53 8.8e-16 -8.8 8.2 1.9e-16 -0.80 0.72 0.28 FALSE
48 GTEx Prostate RP11-613D13.5 0.29 0.07 enet 27 0.16 8.2e-05 -8.8 7.1 1.2e-12 -0.67 0.25 0.36 FALSE
49 GTEx Skin Not Sun Exposed Suprapubic HSD17B12 0.45 0.59 lasso 1 0.59 1.9e-39 -8.8 8.8 1.2e-18 -0.80 0.81 0.19 FALSE
50 GTEx Skin Not Sun Exposed Suprapubic RP11-613D13.5 0.17 0.12 enet 19 0.15 2.2e-08 -8.7 9.1 1.2e-19 -0.92 0.04 0.96 FALSE
51 GTEx Skin Sun Exposed Lower leg HSD17B12 0.46 0.60 lasso 7 0.61 9.2e-63 -8.8 9.0 2.5e-19 -0.83 0.84 0.16 FALSE
52 GTEx Skin Sun Exposed Lower leg RP11-613D13.5 0.17 0.22 lasso 3 0.21 2.2e-17 -8.8 8.9 3.8e-19 -0.83 0.68 0.32 FALSE
53 GTEx Spleen HSD17B12 0.55 0.48 enet 48 0.47 9.6e-14 -8.8 7.2 7.9e-13 -0.73 0.38 0.61 FALSE
54 GTEx Stomach HSD17B12 0.37 0.51 lasso 2 0.51 9.5e-28 -8.8 8.8 1.4e-18 -0.80 0.85 0.15 FALSE
55 GTEx Stomach RP11-613D13.5 0.18 0.21 lasso 3 0.21 1.6e-10 -8.8 8.8 1.3e-18 -0.80 0.83 0.17 FALSE
56 GTEx Testis HSD17B12 0.67 0.58 lasso 10 0.60 8.5e-33 -8.7 8.8 9.2e-19 -0.86 0.88 0.12 FALSE
57 GTEx Thyroid HSD17B12 0.52 0.59 lasso 4 0.59 1.1e-55 -8.8 8.9 5.8e-19 -0.82 0.82 0.18 FALSE
58 GTEx Thyroid RP11-613D13.5 0.24 0.18 lasso 2 0.15 7.3e-12 -8.8 9.0 2.6e-19 -0.83 0.75 0.25 FALSE
59 GTEx Uterus HSD17B12 0.60 0.48 enet 20 0.52 2.1e-12 -8.6 8.2 3.3e-16 -0.81 0.64 0.34 FALSE
60 GTEx Uterus RP11-613D13.5 0.61 0.22 lasso 12 0.26 3.9e-06 -6.8 8.3 1.2e-16 -0.61 0.29 0.40 FALSE
61 GTEx Vagina HSD17B12 0.55 0.31 lasso 19 0.34 1.3e-08 -8.8 8.5 1.7e-17 -0.75 0.41 0.53 FALSE
62 GTEx Whole Blood HSD17B12 0.29 0.36 lasso 3 0.36 4.5e-34 -8.8 8.8 8.8e-19 -0.82 0.85 0.15 FALSE
63 GTEx Whole Blood RP11-613D13.5 0.06 0.01 lasso 4 0.00 1.2e-01 5.0 6.5 8.8e-11 -0.71 0.06 0.32 FALSE
64 METSIM Adipose HSD17B12 0.19 0.29 bslmm 660 0.29 4.7e-43 -8.8 8.5 1.5e-17 -0.82 0.85 0.15 FALSE
65 ROSMAP Brain Pre-frontal Cortex HSD17B12 0.45 0.37 enet 72 0.47 1.1e-68 -8.8 7.2 8.3e-13 -0.72 0.81 0.19 FALSE
66 YFS Blood HSD17B12 0.37 0.44 enet 31 0.47 1.2e-176 -8.7 8.5 2.2e-17 -0.78 0.85 0.15 FALSE
67 TCGA Breast Tumor HSD17B12 0.69 0.58 enet 28 0.60 3.4e-17 -8.8 8.8 1.2e-18 -0.82 0.87 0.13 FALSE
68 TCGA Breast Normal HSD17B12 0.13 0.15 lasso 10 0.16 1.2e-39 -8.7 8.8 1.3e-18 -0.83 0.90 0.10 FALSE
69 TCGA Ovarian Tumor RP11-613D13.5 0.17 0.13 lasso 6 0.17 3.1e-16 -8.6 -8.1 4.0e-16 0.77 0.87 0.13 FALSE
70 TCGA Prostate Tumor HSD17B12 0.31 0.33 enet 31 0.36 6.9e-49 -8.7 8.7 2.3e-18 -0.81 0.87 0.13 FALSE