[Hub]/) : Traits : Arm fat mass (left) :

chr11:46,565,407-48,485,877

Best TWAS P=9.81e-26 · Best GWAS P=1.24e-26 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FAM180B 0.07 0.08 lasso 3 0.08 9.1e-10 -10.5 -9.8 6.7e-23 0.95 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex MADD 0.32 0.17 bslmm 315 0.18 1.4e-21 5.6 -5.9 3.0e-09 0.19 1.00 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex MTCH2 0.03 0.00 bslmm 299 0.00 1.1e-01 -2.4 -6.2 5.6e-10 0.68 0.07 0.54 FALSE
4 GTEx Adipose Subcutaneous ACP2 0.08 0.03 enet 18 0.03 3.5e-03 2.3 -7.1 1.1e-12 0.73 0.08 0.78 FALSE
5 GTEx Adipose Subcutaneous C1QTNF4 0.16 0.22 lasso 4 0.22 2.5e-18 -10.7 10.2 1.6e-24 -0.98 0.00 1.00 FALSE
6 GTEx Artery Aorta MADD 0.09 0.03 enet 22 0.04 1.9e-03 8.8 -6.3 3.7e-10 0.12 0.14 0.04 TRUE
7 GTEx Artery Aorta C1QTNF4 0.09 0.10 lasso 1 0.08 3.2e-05 -10.5 10.5 9.8e-26 -1.00 0.00 0.99 TRUE
8 GTEx Brain Cerebellar Hemisphere MADD 0.44 0.14 lasso 7 0.21 4.0e-06 2.3 -5.5 4.4e-08 0.50 0.33 0.19 FALSE
9 GTEx Brain Cerebellar Hemisphere RP11-750H9.5 0.17 0.25 lasso 6 0.21 3.5e-06 6.2 -6.2 6.9e-10 0.29 0.43 0.06 FALSE
10 GTEx Brain Cerebellum MADD 0.21 0.00 enet 13 0.11 3.3e-04 3.9 -7.8 5.5e-15 0.63 0.07 0.68 TRUE
11 GTEx Brain Cortex MTCH2 0.21 0.19 lasso 6 0.16 4.0e-05 -8.4 -7.2 8.3e-13 0.79 0.35 0.18 FALSE
12 GTEx Brain Cortex C1QTNF4 0.26 0.04 lasso 8 0.02 1.2e-01 9.5 9.7 2.6e-22 -0.80 0.02 0.58 FALSE
13 GTEx Breast Mammary Tissue C1QTNF4 0.10 0.06 lasso 2 0.03 8.5e-03 -8.2 8.0 1.7e-15 -0.82 0.11 0.67 FALSE
14 GTEx Breast Mammary Tissue (Female) MADD 0.13 0.04 lasso 3 0.05 1.3e-02 -8.2 -8.7 4.6e-18 0.81 0.05 0.32 FALSE
15 GTEx Cells Transformed fibroblasts FNBP4 0.11 0.05 lasso 8 0.08 1.6e-06 9.6 -10.3 1.0e-24 0.88 0.04 0.96 FALSE
16 GTEx Cells Transformed fibroblasts MADD 0.19 0.00 enet 17 0.09 3.3e-07 4.1 -6.6 3.2e-11 0.30 0.53 0.04 FALSE
17 GTEx Cells Transformed fibroblasts PSMC3 0.07 0.00 enet 13 0.02 2.3e-02 1.9 -7.2 6.3e-13 0.83 0.03 0.77 FALSE
18 GTEx Cells Transformed fibroblasts C1QTNF4 0.13 0.11 enet 19 0.12 5.2e-09 -8.7 8.5 1.4e-17 -0.84 0.03 0.97 FALSE
19 GTEx Cells Transformed fibroblasts NDUFS3 0.08 0.01 lasso 2 0.01 3.3e-02 -10.7 10.1 3.5e-24 -0.98 0.00 0.98 FALSE
20 GTEx Colon Transverse C1QTNF4 0.07 0.02 lasso 6 0.03 2.0e-02 -10.7 10.0 2.3e-23 -0.96 0.01 0.96 FALSE
21 GTEx Esophagus Mucosa MADD 0.27 0.04 enet 18 0.12 4.1e-08 4.3 -7.7 1.2e-14 0.40 0.26 0.08 TRUE
22 GTEx Esophagus Mucosa C1QTNF4 0.10 0.11 lasso 1 0.10 5.0e-07 -10.5 10.5 9.8e-26 -1.00 0.00 1.00 FALSE
23 GTEx Esophagus Muscularis MTCH2 0.09 0.04 lasso 6 0.02 1.8e-02 -8.7 -9.0 2.0e-19 0.78 0.26 0.53 FALSE
24 GTEx Esophagus Muscularis MADD 0.13 0.07 enet 8 0.11 2.0e-07 5.6 -5.9 3.6e-09 0.17 0.73 0.01 FALSE
25 GTEx Esophagus Muscularis C1QTNF4 0.10 0.05 enet 23 0.06 1.4e-04 -10.7 9.6 8.8e-22 -0.93 0.01 0.99 FALSE
26 GTEx Heart Atrial Appendage ACP2 0.10 0.12 enet 7 0.10 2.7e-05 4.4 -5.3 1.1e-07 0.49 0.32 0.07 TRUE
27 GTEx Heart Atrial Appendage C1QTNF4 0.26 0.14 lasso 9 0.17 3.9e-08 -10.5 10.2 3.3e-24 -0.95 0.02 0.98 FALSE
28 GTEx Heart Left Ventricle MADD 0.14 0.01 enet 17 0.05 7.0e-04 3.1 -7.7 1.0e-14 0.70 0.02 0.95 FALSE
29 GTEx Heart Left Ventricle C1QTNF4 0.10 0.11 lasso 1 0.09 1.1e-05 -10.5 10.5 9.8e-26 -1.00 0.00 0.99 FALSE
30 GTEx Liver PSMC3 0.15 0.09 lasso 4 0.07 5.9e-03 -5.1 -5.5 3.6e-08 0.59 0.09 0.10 FALSE
31 GTEx Liver C1QTNF4 0.25 0.14 enet 16 0.20 2.3e-06 -10.5 10.4 1.5e-25 -0.84 0.02 0.97 FALSE
32 GTEx Lung C1QTNF4 0.18 0.15 lasso 6 0.13 3.2e-10 -8.1 9.1 1.1e-19 -0.91 0.09 0.91 FALSE
33 GTEx Muscle Skeletal MTCH2 0.05 0.03 enet 15 0.04 1.5e-04 -8.0 -8.7 2.9e-18 0.84 0.05 0.94 FALSE
34 GTEx Muscle Skeletal C1QTNF4 0.09 0.14 lasso 3 0.13 9.9e-13 -10.5 10.2 2.0e-24 -0.98 0.00 1.00 FALSE
35 GTEx Nerve Tibial NR1H3 0.10 0.00 enet 24 0.08 4.7e-06 1.7 7.7 1.8e-14 -0.52 0.01 0.82 FALSE
36 GTEx Nerve Tibial CELF1 0.08 0.02 enet 15 0.06 4.3e-05 9.5 -6.3 3.6e-10 0.40 0.21 0.04 FALSE
37 GTEx Nerve Tibial C1QTNF4 0.20 0.23 enet 12 0.23 1.7e-16 -10.5 9.6 6.3e-22 -0.96 0.00 1.00 FALSE
38 GTEx Pituitary MADD 0.42 0.32 lasso 6 0.39 8.9e-11 5.5 -8.4 3.5e-17 0.60 0.25 0.63 FALSE
39 GTEx Skin Not Sun Exposed Suprapubic C1QTNF4 0.32 0.18 enet 33 0.20 5.2e-11 -10.5 9.3 1.7e-20 -0.90 0.00 1.00 FALSE
40 GTEx Skin Sun Exposed Lower leg C1QTNF4 0.25 0.22 lasso 12 0.23 4.2e-19 -10.5 10.3 6.8e-25 -0.95 0.00 1.00 FALSE
41 GTEx Spleen C1QTNF4 0.31 0.28 enet 29 0.34 1.8e-09 -8.4 9.9 5.3e-23 -0.89 0.08 0.92 FALSE
42 GTEx Testis MTCH2 0.17 0.16 lasso 3 0.16 1.0e-07 -8.2 -8.2 1.7e-16 0.83 0.52 0.48 FALSE
43 GTEx Testis C1QTNF4 0.14 0.12 lasso 4 0.11 1.6e-05 9.7 9.8 1.3e-22 -0.73 0.28 0.67 FALSE
44 GTEx Thyroid MADD 0.11 0.00 enet 13 0.01 6.1e-02 1.9 -5.6 2.4e-08 0.25 0.06 0.04 FALSE
45 GTEx Whole Blood C1QTNF4 0.09 0.05 lasso 3 0.03 1.4e-03 -8.4 8.5 2.1e-17 -0.86 0.18 0.72 FALSE
46 METSIM Adipose ACP2 0.05 0.04 blup 302 0.06 1.7e-09 -8.2 -5.4 6.9e-08 0.67 0.36 0.64 FALSE
47 METSIM Adipose C1QTNF4 0.24 0.31 lasso 7 0.31 1.2e-46 -8.5 8.3 1.3e-16 -0.86 1.00 0.00 FALSE
48 METSIM Adipose MYBPC3 0.11 0.10 enet 26 0.11 1.0e-15 -8.2 7.2 4.4e-13 -0.81 0.32 0.68 TRUE
49 METSIM Adipose PSMC3 0.06 0.03 enet 28 0.04 2.3e-06 -3.2 -5.9 3.4e-09 0.79 0.03 0.96 TRUE
50 NTR Blood MTCH2 0.02 0.04 lasso 1 0.04 1.3e-11 -8.7 8.7 4.0e-18 -0.88 0.89 0.11 FALSE
51 ROSMAP Brain Pre-frontal Cortex MTCH2 0.35 0.40 enet 9 0.40 4.7e-56 -8.5 -9.0 2.2e-19 0.91 1.00 0.00 FALSE
52 ROSMAP Brain Pre-frontal Cortex FNBP4 0.04 0.04 lasso 3 0.04 8.2e-06 9.7 -10.3 4.4e-25 0.69 0.93 0.07 FALSE
53 ROSMAP Brain Pre-frontal Cortex MADD 0.33 0.16 enet 23 0.23 1.9e-29 5.6 -5.4 8.0e-08 0.08 1.00 0.00 FALSE
54 ROSMAP Brain Pre-frontal Cortex ACP2 0.03 0.00 blup 295 0.02 1.5e-03 -8.1 -6.3 2.5e-10 0.72 0.06 0.87 FALSE
55 ROSMAP Brain Pre-frontal Cortex C1QTNF4 0.05 0.06 blup 281 0.06 1.7e-08 -8.2 7.3 3.1e-13 -0.86 0.11 0.89 TRUE
56 YFS Blood FNBP4 0.02 0.01 bslmm 301 0.01 8.9e-05 9.0 -9.5 1.4e-21 0.78 0.03 0.95 FALSE
57 YFS Blood PSMC3 0.02 0.01 blup 289 0.01 2.8e-05 -10.7 -7.1 9.0e-13 0.84 0.00 0.99 FALSE
58 YFS Blood PTPMT1 0.03 0.01 lasso 5 0.01 3.2e-04 9.7 7.8 5.1e-15 -0.67 0.27 0.61 FALSE
59 YFS Blood SPI1 0.65 0.18 enet 75 0.27 1.6e-87 -8.1 6.0 2.2e-09 -0.62 1.00 0.00 TRUE
60 TCGA Breast Normal MADD 0.03 0.01 blup 309 0.02 1.1e-05 5.6 -9.6 7.3e-22 0.63 0.04 0.71 FALSE
61 TCGA Ovarian Tumor Y_RNA 0.09 0.08 blup 263 0.06 6.6e-07 -10.7 9.3 9.9e-21 -0.94 0.00 1.00 FALSE