[Hub]/) : Traits : Arm fat mass (left) :

chr12:121,194,565-125,270,773

Best TWAS P=5.78e-20 · Best GWAS P=5.92e-22 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CCDC62 0.12 0.06 enet 21 0.06 3.3e-08 -4.0 5.1 3.1e-07 0.13 0.99 0.00 TRUE
2 CommonMind Brain Pre-frontal Cortex HIP1R 0.06 0.02 lasso 6 0.04 1.9e-05 6.1 5.8 7.5e-09 0.09 0.18 0.02 FALSE
3 GTEx Adipose Subcutaneous ZCCHC8 0.04 0.00 lasso 7 0.00 1.4e-01 -5.7 -6.2 5.9e-10 -0.31 0.17 0.10 FALSE
4 GTEx Adipose Subcutaneous CCDC92 0.23 0.04 enet 27 0.16 6.9e-13 5.3 -8.1 4.3e-16 -0.09 0.02 0.98 TRUE
5 GTEx Adipose Subcutaneous RP11-380L11.3 0.09 0.03 lasso 3 0.03 1.4e-03 -6.0 -8.2 1.9e-16 -0.07 0.07 0.90 FALSE
6 GTEx Adipose Visceral Omentum CCDC92 0.19 0.02 lasso 8 0.09 3.3e-05 -6.1 -9.1 5.8e-20 -0.12 0.03 0.96 TRUE
7 GTEx Adipose Visceral Omentum RP11-380L11.3 0.15 0.03 lasso 5 0.01 1.4e-01 -6.2 -8.9 5.3e-19 -0.08 0.02 0.90 TRUE
8 GTEx Artery Tibial RP11-380L11.4 0.14 0.12 lasso 4 0.12 2.2e-09 -6.0 -5.9 4.8e-09 -0.04 0.21 0.79 FALSE
9 GTEx Brain Putamen basal ganglia WDR66 0.25 0.01 enet 16 -0.01 5.6e-01 -6.8 5.7 1.3e-08 0.15 0.06 0.26 FALSE
10 GTEx Breast Mammary Tissue (Male) CCDC92 0.06 -0.01 lasso 3 0.00 4.3e-01 -5.2 -5.9 3.2e-09 -0.07 0.04 0.08 FALSE
11 GTEx Breast Mammary Tissue (Female) CCDC92 0.05 -0.01 enet 2 -0.01 6.2e-01 -5.1 -5.1 3.8e-07 -0.04 0.04 0.18 FALSE
12 GTEx Breast Mammary Tissue (Female) C12orf65 0.06 0.00 enet 13 -0.01 6.5e-01 3.8 6.0 2.7e-09 0.27 0.04 0.13 FALSE
13 GTEx Cells Transformed fibroblasts BCL7A 0.06 0.01 lasso 4 0.01 3.1e-02 -4.3 7.4 1.7e-13 0.24 0.09 0.05 TRUE
14 GTEx Colon Sigmoid RP11-380L11.4 0.21 0.12 lasso 3 0.08 1.1e-03 -6.0 -6.1 8.8e-10 -0.06 0.15 0.62 FALSE
15 GTEx Colon Transverse MLXIP 0.20 0.18 enet 23 0.14 5.8e-07 -7.4 -7.2 7.4e-13 -0.17 1.00 0.00 TRUE
16 GTEx Colon Transverse SNRNP35 0.18 0.02 lasso 8 0.04 6.5e-03 4.0 -6.7 1.7e-11 -0.16 0.06 0.32 TRUE
17 GTEx Esophagus Mucosa KDM2B 0.11 0.04 enet 22 0.10 4.1e-07 -3.0 -6.8 1.2e-11 -0.10 0.92 0.01 TRUE
18 GTEx Esophagus Mucosa CCDC92 0.11 0.02 lasso 4 0.02 1.9e-02 -5.3 -5.5 4.3e-08 -0.05 0.28 0.39 FALSE
19 GTEx Esophagus Mucosa HIP1R 0.21 0.05 lasso 5 0.07 1.5e-05 -4.0 -7.5 4.4e-14 -0.21 0.47 0.26 TRUE
20 GTEx Esophagus Muscularis RP11-380L11.4 0.27 0.29 lasso 8 0.27 1.0e-16 -6.1 -6.0 1.5e-09 -0.05 0.18 0.82 FALSE
21 GTEx Heart Atrial Appendage CCDC92 0.12 0.11 enet 9 0.11 1.1e-05 -4.6 -5.9 4.0e-09 -0.05 0.26 0.64 FALSE
22 GTEx Heart Atrial Appendage RP11-380L11.4 0.18 0.11 lasso 7 0.12 6.5e-06 -6.1 -6.9 5.1e-12 -0.07 0.16 0.81 FALSE
23 GTEx Heart Left Ventricle CCDC92 0.26 0.19 lasso 4 0.21 1.9e-11 -5.3 -6.7 1.9e-11 -0.06 0.37 0.63 FALSE
24 GTEx Lung CCDC92 0.14 0.00 enet 10 0.01 1.1e-01 -6.9 -7.1 1.6e-12 -0.08 0.00 0.97 FALSE
25 GTEx Lung RP11-380L11.4 0.07 0.07 lasso 3 0.07 8.2e-06 -6.2 -6.0 1.5e-09 -0.06 0.17 0.82 FALSE
26 GTEx Muscle Skeletal RSRC2 0.06 0.03 enet 7 0.04 9.6e-05 3.0 6.3 4.0e-10 0.43 0.25 0.48 FALSE
27 GTEx Nerve Tibial CCDC92 0.16 0.01 enet 6 0.04 6.7e-04 -5.2 -7.2 6.9e-13 -0.10 0.11 0.47 FALSE
28 GTEx Nerve Tibial KNTC1 0.12 0.05 lasso 5 0.05 1.9e-04 6.1 6.8 1.2e-11 0.31 0.53 0.03 FALSE
29 GTEx Prostate CCDC92 0.31 0.10 enet 42 0.11 9.0e-04 -5.1 -5.2 2.5e-07 -0.08 0.14 0.36 FALSE
30 GTEx Skin Sun Exposed Lower leg WDR66 0.19 0.10 lasso 5 0.08 5.5e-07 -3.5 -5.2 1.7e-07 -0.11 0.99 0.00 TRUE
31 GTEx Testis ABCB9 0.14 0.05 lasso 3 0.06 8.0e-04 -6.7 5.9 4.1e-09 0.22 0.25 0.05 TRUE
32 GTEx Thyroid CCDC92 0.06 0.03 lasso 3 0.02 1.1e-02 -6.1 -7.5 6.9e-14 -0.08 0.16 0.72 FALSE
33 GTEx Thyroid ZNF664 0.13 0.06 lasso 11 0.08 6.7e-07 -5.1 5.9 4.5e-09 0.04 0.25 0.75 FALSE
34 GTEx Whole Blood DDX55 0.13 0.04 enet 13 0.06 3.3e-06 3.3 -5.2 2.5e-07 -0.17 0.34 0.02 FALSE
35 METSIM Adipose ABCB9 0.04 0.03 enet 19 0.03 7.7e-05 6.1 7.6 4.1e-14 0.38 0.08 0.65 TRUE
36 METSIM Adipose CCDC92 0.10 0.01 bslmm 435 0.06 5.5e-10 3.1 -7.7 1.1e-14 -0.08 0.01 0.99 FALSE
37 METSIM Adipose MORN3 0.06 0.02 lasso 10 0.04 8.7e-07 -5.0 -5.8 6.3e-09 -0.05 0.95 0.00 FALSE
38 METSIM Adipose RP11-214K3.24 0.05 0.03 bslmm 444 0.02 2.7e-04 -5.3 -6.9 4.8e-12 -0.07 0.19 0.68 FALSE
39 YFS Blood PSMD9 0.04 0.03 bslmm 324 0.05 8.2e-15 5.3 -5.5 4.1e-08 -0.08 1.00 0.00 FALSE
40 TCGA Breast Tumor DDX55 0.25 0.03 blup 364 0.12 8.6e-04 1.9 -6.2 6.2e-10 -0.17 0.41 0.02 FALSE
41 TCGA Breast Normal DNAH10 0.12 0.02 bslmm 476 0.08 4.0e-21 -5.3 -5.1 3.4e-07 -0.10 0.60 0.40 TRUE
42 TCGA Breast Normal VPS33A 0.03 0.02 lasso 4 0.02 1.0e-05 -5.8 5.9 3.1e-09 0.16 0.28 0.05 FALSE
43 TCGA Ovarian Tumor DNAH10 0.05 0.00 blup 71 0.01 4.6e-02 -5.2 -7.1 1.8e-12 -0.04 0.01 0.17 FALSE