TWAS
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Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Arm fat mass (left)
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chr17:15,149,905-16,576,609
Best TWAS P=3.26e-08 · Best GWAS P=4.83e-07 conditioned to 0.522
15.2M
15.4M
15.6M
15.8M
16M
16.2M
16.4M
16.6M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Whole Blood
ADORA2B
0.08
0.00
lasso
5
0.00
2.5e-01
-4.9
-5.5
3.3e-08
0.85
0.05
0.60
TRUE
1
GTEx
Spleen
ADORA2B
0.23
0.27
enet
10
0.24
7.4e-07
-5.0
-5.1
2.7e-07
0.97
0.05
0.94
FALSE
3
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
TTC19
0.03
0.03
enet
8
0.03
2.0e-04
-5.0
5.1
3.1e-07
-0.97
0.03
0.95
FALSE