[Hub]/) : Traits : Arm fat mass (left) :

chr16:2,741,812-5,706,977

Best TWAS P=8.68e-19 · Best GWAS P=2.74e-26 conditioned to 1.12e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta UBN1 0.18 0.15 lasso 4 0.14 6.8e-08 -6.1 5.5 4.8e-08 -0.04 0.13 0.87 FALSE
2 GTEx Artery Tibial UBN1 0.20 0.06 lasso 7 0.07 4.8e-06 -5.5 5.1 3.8e-07 -0.02 0.43 0.56 FALSE
3 GTEx Brain Cerebellar Hemisphere ZNF500 0.27 0.13 enet 13 0.12 4.4e-04 -2.5 -5.4 6.4e-08 0.00 0.21 0.45 FALSE
4 GTEx Brain Cerebellum SLX4 0.33 0.14 lasso 3 0.10 6.8e-04 -5.2 5.3 8.6e-08 -0.01 0.16 0.05 FALSE
5 GTEx Brain Frontal Cortex BA9 NLRC3 0.50 0.18 enet 30 0.33 1.6e-09 -2.7 5.7 1.2e-08 0.03 0.44 0.06 TRUE
6 GTEx Brain Hippocampus CLUAP1 0.37 0.10 lasso 5 0.09 4.9e-03 -4.5 -5.4 5.7e-08 0.02 0.17 0.06 FALSE
7 GTEx Esophagus Mucosa UBN1 0.12 0.06 lasso 3 0.08 5.1e-06 -5.6 5.9 4.6e-09 -0.05 0.11 0.89 FALSE
8 GTEx Esophagus Muscularis UBN1 0.18 0.19 lasso 4 0.19 9.1e-12 -6.1 5.9 3.0e-09 -0.04 0.26 0.74 FALSE
9 GTEx Lung ZSCAN32 0.08 0.02 lasso 3 0.02 6.3e-03 -5.2 -5.3 1.1e-07 0.04 0.05 0.55 FALSE
10 GTEx Muscle Skeletal ZNF500 0.06 0.00 enet 15 0.00 2.8e-01 -2.5 -5.2 2.6e-07 0.05 0.06 0.14 FALSE
11 GTEx Nerve Tibial UBN1 0.14 0.12 lasso 4 0.11 5.6e-08 -6.0 6.0 1.4e-09 -0.04 0.25 0.74 FALSE
12 GTEx Pancreas CLUAP1 0.28 0.21 lasso 3 0.24 2.3e-10 -5.2 -5.1 3.5e-07 0.03 0.99 0.00 FALSE
13 GTEx Skin Not Sun Exposed Suprapubic UBN1 0.22 0.16 lasso 4 0.14 2.5e-08 -5.6 5.1 2.9e-07 -0.04 0.35 0.64 FALSE
14 GTEx Skin Sun Exposed Lower leg CLUAP1 0.34 0.25 lasso 6 0.27 1.1e-22 -5.2 -5.3 1.1e-07 0.04 1.00 0.00 FALSE
15 GTEx Skin Sun Exposed Lower leg PPL 0.10 0.04 lasso 6 0.02 5.7e-03 -5.6 -5.4 7.3e-08 0.05 0.08 0.70 FALSE
16 GTEx Skin Sun Exposed Lower leg UBN1 0.16 0.15 lasso 5 0.17 9.5e-14 -6.1 5.7 1.6e-08 -0.05 0.27 0.73 FALSE
17 ROSMAP Brain Pre-frontal Cortex RP11-462G12.1 0.11 0.07 enet 18 0.06 1.1e-08 10.2 8.8 8.7e-19 0.86 0.00 1.00 TRUE
18 TCGA Breast Normal ADCY9 0.02 0.01 lasso 3 0.01 1.7e-03 5.6 -7.1 1.0e-12 -0.72 0.02 0.92 FALSE
19 TCGA Breast Normal DNASE1 0.03 0.00 bslmm 363 0.00 4.4e-02 -5.9 6.3 2.8e-10 0.30 0.04 0.18 TRUE
20 TCGA Breast Normal MGRN1 0.04 0.00 blup 420 0.01 1.3e-03 -5.6 6.2 5.2e-10 -0.06 0.03 0.74 TRUE
21 TCGA Breast Normal NLRC3 0.06 0.01 blup 372 0.03 1.8e-07 -3.2 5.2 2.2e-07 0.02 0.36 0.10 FALSE
22 TCGA Prostate Tumor ANKS3 0.04 0.00 blup 405 0.01 5.1e-02 -6.2 -5.3 1.3e-07 -0.02 0.01 0.05 FALSE
23 TCGA Prostate Tumor NLRC3 0.26 0.12 enet 25 0.22 8.8e-28 -3.2 5.4 7.4e-08 -0.01 1.00 0.00 FALSE
24 TCGA Prostate Tumor ROGDI 0.10 0.10 lasso 6 0.09 1.9e-11 -5.3 5.7 9.9e-09 -0.02 0.32 0.51 FALSE