[Hub]/) : Traits : Arm fat mass (left) :

chr16:68,467,643-72,845,749

Best TWAS P=1.6e-17 · Best GWAS P=5.71e-17 conditioned to 0.00038

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex EXOSC6 0.24 0.25 enet 14 0.24 1.5e-29 6.00 6.2 6.3e-10 0.28 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex PHLPP2 0.04 0.01 bslmm 456 0.02 4.7e-04 3.22 5.6 2.0e-08 -0.01 0.51 0.38 TRUE
3 CommonMind Brain Pre-frontal Cortex WWP2 0.10 0.04 bslmm 274 0.06 4.4e-08 6.69 -6.8 1.1e-11 -0.39 0.98 0.01 FALSE
4 GTEx Adipose Subcutaneous EXOSC6 0.27 0.28 enet 26 0.32 3.1e-27 5.93 6.7 2.4e-11 0.27 1.00 0.00 FALSE
5 GTEx Adipose Subcutaneous RP11-296I10.6 0.30 0.27 lasso 7 0.31 8.4e-26 5.95 6.1 9.1e-10 0.26 1.00 0.00 FALSE
6 GTEx Adipose Visceral Omentum EXOSC6 0.26 0.29 lasso 6 0.32 3.3e-17 5.93 6.1 8.3e-10 0.31 1.00 0.00 FALSE
7 GTEx Adrenal Gland EXOSC6 0.22 0.18 enet 6 0.17 1.1e-06 5.93 6.4 1.3e-10 0.22 0.82 0.01 FALSE
8 GTEx Adrenal Gland RP11-296I10.6 0.13 0.09 enet 18 0.04 1.4e-02 5.95 5.8 7.8e-09 0.15 0.29 0.04 FALSE
9 GTEx Artery Aorta EXOSC6 0.36 0.32 enet 8 0.34 1.8e-19 5.93 6.0 2.3e-09 0.22 1.00 0.00 FALSE
10 GTEx Artery Aorta RP11-296I10.6 0.23 0.32 enet 7 0.29 2.2e-16 5.93 5.8 9.0e-09 0.20 1.00 0.00 FALSE
11 GTEx Artery Coronary EXOSC6 0.29 0.24 enet 10 0.20 2.1e-07 5.93 6.1 1.2e-09 0.22 0.99 0.00 FALSE
12 GTEx Artery Tibial PDXDC2P 0.31 0.16 enet 24 0.19 6.3e-15 6.02 5.2 1.5e-07 0.25 1.00 0.00 FALSE
13 GTEx Artery Tibial WWP2 0.13 0.01 enet 17 0.02 4.9e-03 6.93 -6.6 4.1e-11 -0.38 0.50 0.06 FALSE
14 GTEx Artery Tibial EXOSC6 0.27 0.32 enet 10 0.30 5.5e-24 5.95 6.2 4.3e-10 0.25 1.00 0.00 FALSE
15 GTEx Artery Tibial RP11-296I10.6 0.27 0.37 enet 11 0.38 4.3e-31 5.93 5.7 9.7e-09 0.21 1.00 0.00 FALSE
16 GTEx Brain Caudate basal ganglia RP11-296I10.6 0.15 0.08 lasso 3 0.05 1.9e-02 5.95 5.5 3.2e-08 0.18 0.07 0.06 FALSE
17 GTEx Brain Cerebellar Hemisphere PDXDC2P 0.33 0.16 enet 11 0.27 1.4e-07 6.91 6.7 1.8e-11 0.45 0.55 0.17 FALSE
18 GTEx Brain Cerebellar Hemisphere EXOSC6 0.51 0.15 lasso 11 0.26 2.9e-07 5.95 7.1 1.3e-12 0.40 0.44 0.32 FALSE
19 GTEx Brain Cerebellar Hemisphere RP11-296I10.6 0.19 0.20 lasso 5 0.19 1.5e-05 5.93 6.0 1.9e-09 0.24 0.31 0.13 FALSE
20 GTEx Brain Cerebellum PDPR 0.23 0.06 enet 20 0.11 3.7e-04 5.93 7.8 5.0e-15 0.21 0.08 0.12 FALSE
21 GTEx Brain Cerebellum PDXDC2P 0.39 0.20 lasso 8 0.32 2.7e-10 -3.90 5.4 5.7e-08 0.33 0.93 0.05 FALSE
22 GTEx Brain Cerebellum RP11-296I10.3 0.20 0.03 enet 12 0.14 8.8e-05 5.95 8.5 1.6e-17 0.28 0.05 0.15 TRUE
23 GTEx Brain Cerebellum RP11-296I10.6 0.18 0.21 lasso 2 0.18 5.8e-06 5.93 6.0 1.9e-09 0.25 0.64 0.06 FALSE
24 GTEx Brain Frontal Cortex BA9 RP11-296I10.6 0.18 0.12 lasso 4 0.10 1.3e-03 -3.51 5.1 3.3e-07 0.18 0.19 0.05 FALSE
25 GTEx Brain Hippocampus EXOSC6 0.17 0.06 lasso 4 0.03 6.7e-02 5.93 6.6 4.0e-11 0.25 0.05 0.08 FALSE
26 GTEx Brain Nucleus accumbens basal ganglia EXOSC6 0.22 0.12 enet 12 0.12 3.3e-04 5.93 6.0 2.0e-09 0.37 0.29 0.08 FALSE
27 GTEx Brain Nucleus accumbens basal ganglia RP11-296I10.6 0.15 0.11 lasso 3 0.08 3.0e-03 5.93 7.1 1.1e-12 0.38 0.11 0.22 FALSE
28 GTEx Brain Putamen basal ganglia EXOSC6 0.27 0.22 enet 10 0.15 2.4e-04 5.95 5.8 8.3e-09 0.26 0.14 0.16 FALSE
29 GTEx Brain Putamen basal ganglia RP11-296I10.6 0.24 0.01 enet 18 0.04 3.2e-02 6.93 5.8 5.1e-09 0.39 0.19 0.21 FALSE
30 GTEx Breast Mammary Tissue PDXDC2P 0.55 0.24 enet 35 0.36 1.4e-19 6.03 5.1 2.8e-07 0.15 1.00 0.00 FALSE
31 GTEx Breast Mammary Tissue EXOSC6 0.38 0.34 enet 8 0.34 2.0e-18 5.93 6.1 9.6e-10 0.18 1.00 0.00 FALSE
32 GTEx Breast Mammary Tissue RP11-296I10.6 0.31 0.30 enet 17 0.30 7.1e-16 5.96 6.2 5.2e-10 0.17 1.00 0.00 FALSE
33 GTEx Breast Mammary Tissue (Male) RP11-296I10.6 0.32 0.42 lasso 8 0.47 1.8e-12 5.93 5.9 3.5e-09 0.17 0.95 0.01 FALSE
34 GTEx Breast Mammary Tissue (Female) EXOSC6 0.52 0.26 enet 21 0.27 1.4e-08 5.93 7.9 2.3e-15 0.36 0.71 0.13 FALSE
35 GTEx Breast Mammary Tissue (Female) RP11-296I10.6 0.18 0.17 enet 8 0.13 1.0e-04 5.93 6.2 4.2e-10 0.18 0.33 0.07 FALSE
36 GTEx Cells Transformed fibroblasts AARS 0.07 0.08 lasso 2 0.07 9.7e-06 5.93 -5.9 3.2e-09 -0.21 0.92 0.01 FALSE
37 GTEx Cells Transformed fibroblasts PDXDC2P 0.25 0.10 enet 15 0.21 1.5e-15 4.16 5.5 4.3e-08 0.35 1.00 0.00 FALSE
38 GTEx Cells Transformed fibroblasts EXOSC6 0.18 0.19 enet 12 0.23 2.1e-17 5.93 6.1 1.2e-09 0.26 1.00 0.00 FALSE
39 GTEx Cells Transformed fibroblasts RP11-296I10.6 0.10 0.09 enet 9 0.10 6.1e-08 5.95 6.6 4.4e-11 0.28 1.00 0.00 FALSE
40 GTEx Colon Sigmoid EXOSC6 0.38 0.32 enet 25 0.30 2.4e-11 5.93 5.6 1.7e-08 0.18 1.00 0.00 FALSE
41 GTEx Colon Sigmoid RP11-296I10.6 0.32 0.33 enet 20 0.33 2.2e-12 5.95 6.2 4.1e-10 0.20 1.00 0.00 FALSE
42 GTEx Colon Transverse EXOSC6 0.32 0.31 enet 8 0.31 2.1e-15 5.93 6.3 3.8e-10 0.23 1.00 0.00 FALSE
43 GTEx Colon Transverse RP11-296I10.6 0.34 0.32 enet 8 0.40 2.5e-20 5.95 5.6 2.1e-08 0.16 1.00 0.00 FALSE
44 GTEx Esophagus Gastroesophageal Junction EXOSC6 0.27 0.30 enet 13 0.16 1.9e-06 5.93 5.8 8.4e-09 0.20 1.00 0.00 FALSE
45 GTEx Esophagus Gastroesophageal Junction RP11-296I10.6 0.26 0.22 enet 15 0.20 7.9e-08 5.95 5.3 9.0e-08 0.13 0.96 0.00 FALSE
46 GTEx Esophagus Mucosa EXOSC6 0.12 0.20 enet 5 0.19 1.6e-12 5.93 6.0 1.7e-09 0.22 1.00 0.00 FALSE
47 GTEx Esophagus Mucosa RP11-296I10.6 0.22 0.19 enet 14 0.17 2.0e-11 5.95 5.5 3.3e-08 0.09 1.00 0.00 FALSE
48 GTEx Esophagus Muscularis PDXDC2P 0.35 0.29 enet 28 0.27 1.1e-16 6.02 5.2 1.9e-07 0.24 1.00 0.00 FALSE
49 GTEx Esophagus Muscularis EXOSC6 0.30 0.33 enet 13 0.37 6.7e-24 5.95 6.2 7.9e-10 0.21 1.00 0.00 FALSE
50 GTEx Esophagus Muscularis RP11-296I10.6 0.32 0.27 enet 24 0.32 4.0e-20 5.93 6.0 2.4e-09 0.21 1.00 0.00 FALSE
51 GTEx Heart Atrial Appendage EXOSC6 0.26 0.30 enet 12 0.32 9.7e-15 6.03 5.8 5.1e-09 0.20 1.00 0.00 FALSE
52 GTEx Heart Atrial Appendage RP11-296I10.6 0.18 0.19 enet 16 0.16 1.1e-07 5.95 6.7 2.9e-11 0.27 0.99 0.01 FALSE
53 GTEx Heart Left Ventricle EXOSC6 0.33 0.35 enet 18 0.34 4.0e-19 6.03 5.8 4.8e-09 0.20 1.00 0.00 FALSE
54 GTEx Heart Left Ventricle RP11-296I10.6 0.19 0.27 enet 13 0.28 2.0e-15 6.03 5.8 6.2e-09 0.17 1.00 0.00 FALSE
55 GTEx Liver EXOSC6 0.31 0.22 lasso 10 0.11 6.9e-04 6.03 -6.0 2.6e-09 -0.25 0.34 0.10 FALSE
56 GTEx Lung EXOSC6 0.34 0.40 enet 8 0.39 9.6e-32 6.03 6.0 2.0e-09 0.21 1.00 0.00 FALSE
57 GTEx Lung RP11-296I10.6 0.21 0.32 enet 12 0.33 2.8e-26 5.93 5.7 9.2e-09 0.24 1.00 0.00 FALSE
58 GTEx Muscle Skeletal EXOSC6 0.28 0.32 enet 20 0.32 4.2e-32 5.95 6.3 2.6e-10 0.26 1.00 0.00 FALSE
59 GTEx Muscle Skeletal RP11-296I10.6 0.11 0.15 enet 16 0.15 1.8e-14 5.93 6.4 1.9e-10 0.29 1.00 0.00 FALSE
60 GTEx Nerve Tibial PDXDC2P 0.40 0.24 lasso 9 0.43 9.9e-33 4.16 5.2 1.8e-07 0.32 1.00 0.00 FALSE
61 GTEx Nerve Tibial EXOSC6 0.28 0.37 enet 10 0.41 1.1e-30 5.93 6.0 1.6e-09 0.22 1.00 0.00 FALSE
62 GTEx Nerve Tibial RP11-296I10.6 0.32 0.40 enet 23 0.43 5.1e-33 5.93 6.5 1.1e-10 0.26 1.00 0.00 FALSE
63 GTEx Ovary PDXDC2P 0.45 0.11 lasso 7 0.28 1.6e-07 -3.90 5.7 1.6e-08 0.39 0.48 0.19 FALSE
64 GTEx Ovary EXOSC6 0.32 -0.01 enet 34 0.09 2.7e-03 4.07 5.2 2.3e-07 0.37 0.06 0.21 FALSE
65 GTEx Ovary RP11-296I10.6 0.35 0.28 enet 18 0.27 2.2e-07 5.93 7.4 1.5e-13 0.46 0.18 0.64 FALSE
66 GTEx Pancreas PDXDC2P 0.50 0.26 lasso 10 0.24 1.3e-10 -4.09 5.2 1.5e-07 0.25 1.00 0.00 FALSE
67 GTEx Pancreas EXOSC6 0.38 0.36 lasso 4 0.34 7.3e-15 6.02 6.0 1.7e-09 0.22 1.00 0.00 FALSE
68 GTEx Pancreas RP11-296I10.6 0.20 0.17 enet 9 0.17 1.2e-07 6.02 5.8 6.8e-09 0.14 0.97 0.00 FALSE
69 GTEx Prostate EXOSC6 0.31 0.24 lasso 6 0.23 2.2e-06 5.95 6.0 2.0e-09 0.22 0.49 0.03 FALSE
70 GTEx Prostate RP11-296I10.6 0.20 0.18 lasso 4 0.19 1.9e-05 5.95 6.0 2.5e-09 0.22 0.26 0.04 FALSE
71 GTEx Skin Not Sun Exposed Suprapubic EXOSC6 0.21 0.22 lasso 2 0.22 3.6e-12 5.93 -6.0 2.7e-09 -0.23 1.00 0.00 FALSE
72 GTEx Skin Not Sun Exposed Suprapubic RP11-296I10.6 0.21 0.24 enet 17 0.24 1.4e-13 5.95 5.9 3.3e-09 0.22 1.00 0.00 FALSE
73 GTEx Skin Sun Exposed Lower leg EXOSC6 0.21 0.21 enet 10 0.22 3.9e-18 5.95 6.2 7.3e-10 0.25 1.00 0.00 FALSE
74 GTEx Skin Sun Exposed Lower leg RP11-296I10.6 0.20 0.25 enet 15 0.24 8.4e-20 5.95 5.9 2.8e-09 0.22 1.00 0.00 FALSE
75 GTEx Spleen PDXDC2P 0.44 0.26 lasso 5 0.29 4.6e-08 6.02 5.9 3.8e-09 0.20 0.66 0.07 FALSE
76 GTEx Spleen RP11-296I10.6 0.30 0.20 enet 12 0.16 5.5e-05 5.95 5.8 6.0e-09 0.22 0.55 0.06 FALSE
77 GTEx Stomach EXOSC6 0.36 0.28 enet 9 0.26 1.6e-12 5.95 5.9 3.5e-09 0.21 1.00 0.00 FALSE
78 GTEx Stomach RP11-296I10.6 0.24 0.15 enet 14 0.16 4.5e-08 5.95 6.2 4.3e-10 0.17 0.99 0.00 FALSE
79 GTEx Testis WWP2 0.30 0.10 lasso 5 0.16 9.2e-08 -4.90 -6.7 1.7e-11 -0.53 0.66 0.04 FALSE
80 GTEx Testis RP11-296I10.6 0.10 0.04 enet 7 0.07 6.2e-04 5.95 5.6 2.4e-08 0.27 0.18 0.05 FALSE
81 GTEx Thyroid NOB1 0.03 0.01 enet 6 0.02 7.7e-03 -6.66 7.6 3.6e-14 0.73 0.20 0.36 FALSE
82 GTEx Thyroid EXOSC6 0.12 0.14 lasso 2 0.15 7.9e-12 5.93 6.0 2.5e-09 0.21 1.00 0.00 FALSE
83 GTEx Thyroid CTD-2033A16.3 0.03 0.02 enet 7 0.02 6.7e-03 -4.89 7.0 3.3e-12 0.66 0.21 0.27 FALSE
84 GTEx Uterus PDXDC2P 0.31 0.20 enet 28 0.24 1.3e-05 3.24 5.4 5.3e-08 0.40 0.06 0.50 FALSE
85 GTEx Whole Blood EXOSC6 0.14 0.12 enet 10 0.11 3.5e-10 5.96 6.1 1.1e-09 0.21 1.00 0.00 FALSE
86 GTEx Whole Blood RP11-296I10.6 0.08 0.07 enet 16 0.09 2.3e-08 5.96 6.3 3.6e-10 0.23 1.00 0.00 FALSE
87 METSIM Adipose CLEC18A 0.26 0.18 lasso 15 0.27 4.4e-40 -4.09 6.4 1.2e-10 0.30 1.00 0.00 FALSE
88 METSIM Adipose DHX38 0.08 0.06 lasso 7 0.09 4.5e-13 3.60 -5.2 1.8e-07 0.10 0.12 0.88 TRUE
89 METSIM Adipose EXOSC6 0.30 0.24 bslmm 194 0.25 5.8e-37 5.95 6.0 2.4e-09 0.24 1.00 0.00 FALSE
90 METSIM Adipose NOB1 0.03 0.03 lasso 2 0.03 2.8e-05 -4.41 5.6 1.9e-08 0.76 0.07 0.92 TRUE
91 NTR Blood EXOSC6 0.06 0.07 bslmm 195 0.07 2.7e-22 5.93 6.6 3.9e-11 0.32 1.00 0.00 FALSE
92 ROSMAP Brain Pre-frontal Cortex RP11-296I10.6 0.36 0.42 enet 19 0.42 6.7e-59 6.00 6.3 3.0e-10 0.26 1.00 0.00 FALSE
93 YFS Blood CIRH1A 0.32 0.09 enet 34 0.14 5.4e-45 4.26 -5.2 2.3e-07 -0.05 1.00 0.00 TRUE
94 YFS Blood EXOSC6 0.24 0.24 lasso 5 0.25 2.4e-81 5.93 6.3 2.6e-10 0.27 1.00 0.00 FALSE
95 YFS Blood PDPR 0.02 0.00 enet 20 0.01 1.8e-05 0.81 -6.4 1.6e-10 -0.47 0.05 0.09 FALSE
96 TCGA Breast Tumor PDXDC2 0.39 -0.01 blup 220 0.02 1.1e-01 -4.08 7.3 3.0e-13 0.51 0.03 0.12 FALSE
97 TCGA Breast Normal CLEC18A 0.14 0.09 bslmm 206 0.13 4.2e-34 4.22 7.5 4.6e-14 0.49 1.00 0.00 FALSE
98 TCGA Breast Normal PDXDC2 0.05 0.01 bslmm 219 0.02 1.4e-06 1.77 5.2 1.6e-07 0.25 0.15 0.06 FALSE
99 TCGA Ovarian Tumor PDPR 0.05 0.01 lasso 3 0.01 8.3e-02 4.12 5.7 1.1e-08 0.61 0.09 0.63 FALSE
100 TCGA Ovarian Tumor RP11-296I10.3 0.06 0.01 enet 19 0.07 4.9e-07 6.90 5.4 6.8e-08 0.55 0.06 0.83 FALSE
101 TCGA Prostate Tumor AARS 0.04 0.04 lasso 2 0.03 1.6e-04 -3.51 -5.1 2.9e-07 -0.17 0.28 0.06 FALSE
102 TCGA Prostate Tumor EXOSC6 0.22 0.16 enet 26 0.17 1.9e-21 5.93 5.7 1.2e-08 0.24 1.00 0.00 FALSE