Best TWAS P=2.72e-10 · Best GWAS P=5.99e-08 conditioned to 0.356
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | INPP5E | 0.18 | 0.02 | enet | 23 | 0.10 | 2.2e-04 | 4.7 | -5.2 | 2.3e-07 | -0.63 | 0.08 | 0.64 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | SNHG7 | 0.37 | 0.10 | lasso | 6 | 0.27 | 2.5e-08 | -3.2 | 6.2 | 6.2e-10 | 0.34 | 0.08 | 0.57 | TRUE |
3 | GTEx | Brain Cerebellar Hemisphere | INPP5E | 0.25 | 0.23 | enet | 6 | 0.17 | 3.4e-05 | 4.7 | -5.3 | 1.2e-07 | -0.75 | 0.11 | 0.83 | FALSE |
4 | GTEx | Esophagus Muscularis | SDCCAG3 | 0.10 | 0.02 | enet | 5 | 0.02 | 3.6e-02 | 3.3 | -5.1 | 3.1e-07 | -0.46 | 0.08 | 0.70 | FALSE |
5 | GTEx | Lung | CARD9 | 0.08 | 0.04 | enet | 6 | 0.04 | 2.5e-04 | 5.4 | 5.3 | 1.5e-07 | 0.88 | 0.02 | 0.98 | FALSE |
6 | GTEx | Ovary | INPP5E | 0.24 | 0.13 | enet | 11 | 0.15 | 1.9e-04 | 5.0 | -6.3 | 2.7e-10 | -0.79 | 0.05 | 0.68 | TRUE |
7 | GTEx | Ovary | SEC16A | 0.33 | 0.06 | enet | 10 | 0.14 | 3.4e-04 | 4.6 | -5.6 | 1.6e-08 | -0.65 | 0.04 | 0.34 | FALSE |
8 | GTEx | Uterus | INPP5E | 0.60 | 0.04 | enet | 10 | 0.22 | 3.4e-05 | 5.3 | -5.5 | 3.5e-08 | -0.73 | 0.05 | 0.55 | FALSE |
9 | GTEx | Whole Blood | SEC16A | 0.07 | 0.05 | lasso | 5 | 0.04 | 1.3e-04 | 4.8 | -5.4 | 6.7e-08 | -0.62 | 0.10 | 0.89 | FALSE |
10 | GTEx | Whole Blood | CARD9 | 0.08 | 0.07 | lasso | 1 | 0.05 | 4.2e-05 | 5.4 | 5.4 | 8.3e-08 | 0.98 | 0.02 | 0.98 | FALSE |
11 | YFS | Blood | INPP5E | 0.33 | 0.55 | lasso | 6 | 0.57 | 2.9e-235 | 5.3 | -5.3 | 1.5e-07 | -0.70 | 0.04 | 0.96 | FALSE |
12 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | INPP5E | 0.25 | 0.10 | lasso | 3 | 0.09 | 4.9e-05 | 5.3 | -5.5 | 4.0e-08 | -0.70 | 0.01 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Colon Adenocarcinoma | INPP5E | 0.11 | 0.08 | lasso | 2 | 0.08 | 3.4e-05 | 5.3 | -5.3 | 1.2e-07 | -0.71 | 0.01 | 0.92 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | INPP5E | 0.07 | 0.04 | blup | 54 | 0.07 | 6.0e-05 | 5.4 | -5.8 | 8.8e-09 | -0.81 | 0.01 | 0.95 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SDCCAG3 | 0.05 | 0.01 | blup | 61 | 0.01 | 5.9e-02 | 5.1 | -5.2 | 2.3e-07 | -0.84 | 0.02 | 0.67 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SEC16A | 0.08 | 0.10 | lasso | 4 | 0.08 | 1.9e-08 | 5.4 | -5.2 | 2.1e-07 | -0.57 | 0.00 | 1.00 | FALSE |
17 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | INPP5E | 0.10 | 0.06 | blup | 54 | 0.08 | 8.1e-04 | 4.7 | -5.4 | 6.2e-08 | -0.82 | 0.03 | 0.75 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | INPP5E | 0.11 | 0.16 | lasso | 3 | 0.16 | 2.4e-15 | 5.1 | -5.2 | 1.6e-07 | -0.82 | 0.03 | 0.96 | FALSE |