Best TWAS P=2.75e-09 · Best GWAS P=2.28e-07 conditioned to 0.75
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | CDC16 | 0.12 | 0.11 | lasso | 4 | 0.09 | 1.5e-05 | -5.2 | -5.3 | 1.4e-07 | 0.98 | 0.01 | 0.98 | FALSE |
2 | GTEx | Artery Aorta | CDC16 | 0.15 | 0.18 | enet | 10 | 0.17 | 1.6e-09 | -5.0 | -5.2 | 1.7e-07 | 0.97 | 0.02 | 0.98 | FALSE |
3 | GTEx | Artery Coronary | CDC16 | 0.41 | 0.02 | enet | 5 | 0.02 | 6.9e-02 | -4.7 | -5.3 | 1.2e-07 | 0.90 | 0.02 | 0.93 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | CDC16 | 0.17 | 0.10 | lasso | 9 | 0.17 | 3.5e-05 | -5.2 | -5.2 | 2.4e-07 | 0.92 | 0.02 | 0.96 | FALSE |
5 | GTEx | Breast Mammary Tissue | CDC16 | 0.25 | 0.28 | lasso | 6 | 0.26 | 6.9e-14 | -5.2 | -5.6 | 2.0e-08 | 0.96 | 0.01 | 0.98 | FALSE |
6 | GTEx | Breast Mammary Tissue (Male) | CDC16 | 0.23 | 0.08 | enet | 11 | 0.09 | 3.8e-03 | -5.1 | -5.9 | 2.7e-09 | 0.84 | 0.02 | 0.88 | TRUE |
7 | GTEx | Breast Mammary Tissue (Female) | CDC16 | 0.25 | 0.22 | enet | 28 | 0.22 | 3.6e-07 | -5.2 | -5.5 | 3.4e-08 | 0.92 | 0.02 | 0.98 | FALSE |
8 | GTEx | Colon Transverse | CDC16 | 0.18 | 0.23 | lasso | 5 | 0.21 | 3.2e-10 | -5.2 | -5.4 | 5.8e-08 | 0.98 | 0.02 | 0.98 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | CDC16 | 0.09 | 0.05 | lasso | 2 | 0.02 | 5.7e-02 | -5.2 | -5.3 | 1.4e-07 | 0.99 | 0.02 | 0.88 | FALSE |
10 | GTEx | Lung | CDC16 | 0.16 | 0.21 | lasso | 5 | 0.19 | 9.6e-15 | -5.2 | -5.3 | 1.5e-07 | 0.99 | 0.01 | 0.99 | FALSE |
11 | GTEx | Nerve Tibial | CDC16 | 0.23 | 0.23 | enet | 19 | 0.26 | 9.5e-19 | -5.2 | -5.5 | 3.1e-08 | 0.95 | 0.01 | 0.98 | FALSE |
12 | GTEx | Pancreas | CDC16 | 0.09 | 0.14 | lasso | 3 | 0.06 | 1.8e-03 | -5.2 | -5.2 | 2.4e-07 | 0.99 | 0.01 | 0.96 | FALSE |
13 | GTEx | Prostate | CDC16 | 0.17 | 0.16 | lasso | 3 | 0.11 | 1.4e-03 | -5.2 | -5.2 | 2.5e-07 | 1.00 | 0.02 | 0.92 | FALSE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | CDC16 | 0.35 | 0.42 | enet | 33 | 0.45 | 7.9e-27 | -5.0 | -5.3 | 1.5e-07 | 0.96 | 0.02 | 0.98 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | CDC16 | 0.31 | 0.33 | lasso | 7 | 0.33 | 4.1e-28 | -5.0 | -5.3 | 9.5e-08 | 0.98 | 0.02 | 0.98 | FALSE |
16 | GTEx | Spleen | CDC16 | 0.25 | 0.19 | lasso | 7 | 0.21 | 4.9e-06 | -5.0 | -5.2 | 2.2e-07 | 0.97 | 0.02 | 0.96 | FALSE |
17 | GTEx | Testis | CDC16 | 0.32 | 0.30 | enet | 26 | 0.35 | 4.4e-16 | -5.2 | -5.7 | 1.1e-08 | 0.94 | 0.01 | 0.98 | FALSE |
18 | METSIM | Adipose | CDC16 | 0.18 | 0.27 | enet | 18 | 0.26 | 6.6e-39 | -5.2 | -5.3 | 1.4e-07 | 0.96 | 0.01 | 0.99 | FALSE |
19 | YFS | Blood | CDC16 | 0.28 | 0.54 | enet | 30 | 0.55 | 1.1e-220 | -5.0 | -5.2 | 2.0e-07 | 0.99 | 0.02 | 0.98 | FALSE |
20 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CDC16 | 0.08 | 0.11 | lasso | 5 | 0.12 | 4.3e-10 | -5.2 | -5.2 | 2.3e-07 | 0.99 | 0.01 | 0.98 | FALSE |
21 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDC16 | 0.01 | 0.01 | blup | 49 | 0.01 | 1.1e-03 | -5.1 | -5.2 | 2.6e-07 | 0.97 | 0.02 | 0.94 | FALSE |
22 | The Cancer Genome Atlas | Colon Adenocarcinoma | CDC16 | 0.06 | 0.04 | lasso | 5 | 0.03 | 5.9e-03 | -4.9 | -5.3 | 9.4e-08 | 0.88 | 0.02 | 0.89 | FALSE |
23 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CDC16 | 0.05 | 0.08 | lasso | 4 | 0.08 | 7.2e-09 | -5.0 | -5.1 | 2.9e-07 | 0.99 | 0.02 | 0.98 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CDC16 | 0.04 | 0.01 | blup | 49 | 0.03 | 7.7e-03 | -5.2 | -5.4 | 5.1e-08 | 0.96 | 0.02 | 0.93 | FALSE |
25 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CDC16 | 0.11 | 0.09 | blup | 49 | 0.09 | 1.8e-04 | -5.2 | -5.4 | 5.1e-08 | 0.98 | 0.02 | 0.96 | FALSE |
26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CDC16 | 0.08 | 0.07 | blup | 49 | 0.08 | 1.2e-08 | -5.0 | -5.2 | 2.4e-07 | 0.89 | 0.02 | 0.98 | FALSE |
27 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC16 | 0.06 | 0.09 | lasso | 3 | 0.09 | 3.3e-09 | -5.2 | -5.4 | 7.6e-08 | 0.98 | 0.01 | 0.99 | FALSE |