Best TWAS P=7.59e-10 · Best GWAS P=1.68e-07 conditioned to 0.0457
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | SNHG7 | 0.37 | 0.10 | lasso | 6 | 0.27 | 2.5e-08 | -3.0 | 5.9 | 3.8e-09 | 0.39 | 0.07 | 0.56 | FALSE |
2 | GTEx | Ovary | INPP5E | 0.24 | 0.13 | enet | 11 | 0.15 | 1.9e-04 | 4.9 | -6.2 | 7.6e-10 | -0.59 | 0.04 | 0.72 | TRUE |
3 | GTEx | Ovary | SEC16A | 0.33 | 0.06 | enet | 10 | 0.14 | 3.4e-04 | 4.4 | -5.5 | 3.7e-08 | -0.45 | 0.04 | 0.29 | FALSE |
4 | GTEx | Uterus | INPP5E | 0.60 | 0.04 | enet | 10 | 0.22 | 3.4e-05 | 5.1 | -5.3 | 1.4e-07 | -0.53 | 0.04 | 0.56 | FALSE |
5 | GTEx | Whole Blood | SEC16A | 0.07 | 0.05 | lasso | 5 | 0.04 | 1.3e-04 | 4.6 | -5.2 | 2.0e-07 | -0.72 | 0.07 | 0.91 | FALSE |
6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | INPP5E | 0.25 | 0.10 | lasso | 3 | 0.09 | 4.9e-05 | 5.1 | -5.3 | 1.1e-07 | -0.73 | 0.01 | 0.96 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | INPP5E | 0.07 | 0.04 | blup | 54 | 0.07 | 6.0e-05 | 5.3 | -5.5 | 3.3e-08 | -0.84 | 0.01 | 0.95 | FALSE |
8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | INPP5E | 0.10 | 0.06 | blup | 54 | 0.08 | 8.1e-04 | 4.5 | -5.2 | 2.7e-07 | -0.82 | 0.03 | 0.73 | FALSE |