Best TWAS P=4.92e-08 · Best GWAS P=2.68e-07 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | ANAPC4 | 0.32 | 0.40 | lasso | 13 | 0.40 | 7.3e-35 | 5.1 | 5.1 | 2.7e-07 | 0.98 | 0.01 | 0.98 | FALSE |
2 | GTEx | Breast Mammary Tissue | ANAPC4 | 0.49 | 0.42 | lasso | 8 | 0.42 | 1.5e-23 | 5.1 | 5.5 | 4.9e-08 | 0.95 | 0.01 | 0.99 | TRUE |
3 | GTEx | Esophagus Mucosa | ANAPC4 | 0.33 | 0.23 | lasso | 10 | 0.21 | 4.6e-14 | 5.1 | 5.3 | 1.5e-07 | 0.95 | 0.01 | 0.98 | FALSE |
4 | GTEx | Heart Atrial Appendage | ANAPC4 | 0.18 | 0.12 | lasso | 9 | 0.10 | 3.4e-05 | 5.1 | 5.2 | 2.0e-07 | 0.95 | 0.02 | 0.98 | FALSE |
5 | GTEx | Heart Left Ventricle | ANAPC4 | 0.13 | 0.10 | lasso | 7 | 0.07 | 1.6e-04 | 5.0 | 5.3 | 1.4e-07 | 0.95 | 0.02 | 0.97 | FALSE |
6 | GTEx | Lung | ANAPC4 | 0.14 | 0.14 | enet | 11 | 0.13 | 4.4e-10 | 5.0 | 5.2 | 2.6e-07 | 0.99 | 0.02 | 0.98 | FALSE |
7 | GTEx | Nerve Tibial | ANAPC4 | 0.35 | 0.43 | enet | 14 | 0.43 | 4.3e-33 | 5.1 | 5.3 | 1.3e-07 | 0.96 | 0.01 | 0.99 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | ANAPC4 | 0.27 | 0.34 | enet | 23 | 0.34 | 4.4e-29 | 5.1 | 5.2 | 2.1e-07 | 0.95 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ANAPC4 | 0.03 | 0.05 | enet | 10 | 0.04 | 1.9e-05 | 5.1 | 5.3 | 1.4e-07 | 0.88 | 0.01 | 0.99 | FALSE |