Best TWAS P=1.07e-08 · Best GWAS P=1.84e-08 conditioned to 0.23
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EDEM3 | 0.11 | 0.08 | lasso | 14 | 0.11 | 2.3e-13 | 4.7 | -5.6 | 2.4e-08 | -0.88 | 0.01 | 0.98 | FALSE |
2 | GTEx | Adipose Subcutaneous | EDEM3 | 0.15 | 0.13 | lasso | 3 | 0.13 | 1.0e-10 | 5.5 | -5.5 | 3.7e-08 | -0.99 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Visceral Omentum | EDEM3 | 0.15 | 0.07 | lasso | 4 | 0.08 | 7.4e-05 | -5.1 | -5.4 | 6.8e-08 | -0.91 | 0.02 | 0.98 | FALSE |
4 | GTEx | Artery Aorta | EDEM3 | 0.19 | 0.14 | enet | 12 | 0.15 | 9.6e-09 | 5.6 | -5.5 | 3.3e-08 | -0.98 | 0.01 | 0.99 | FALSE |
5 | GTEx | Artery Tibial | EDEM3 | 0.23 | 0.16 | enet | 24 | 0.19 | 1.7e-14 | 5.6 | -5.3 | 1.5e-07 | -0.91 | 0.01 | 0.99 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | EDEM3 | 0.15 | 0.07 | lasso | 3 | 0.08 | 2.4e-06 | 5.6 | -5.5 | 3.8e-08 | -0.98 | 0.01 | 0.99 | FALSE |
7 | GTEx | Colon Sigmoid | EDEM3 | 0.18 | 0.17 | enet | 12 | 0.13 | 2.1e-05 | 4.7 | -5.4 | 5.1e-08 | -0.97 | 0.01 | 0.99 | FALSE |
8 | GTEx | Colon Transverse | EDEM3 | 0.15 | 0.08 | lasso | 6 | 0.09 | 6.2e-05 | 5.6 | -5.6 | 2.6e-08 | -0.96 | 0.02 | 0.98 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | EDEM3 | 0.16 | 0.19 | lasso | 1 | 0.15 | 5.5e-06 | 5.5 | -5.5 | 4.3e-08 | -1.00 | 0.01 | 0.99 | FALSE |
10 | GTEx | Esophagus Muscularis | EDEM3 | 0.14 | 0.10 | enet | 16 | 0.08 | 1.5e-05 | 5.5 | -5.4 | 6.7e-08 | -0.98 | 0.01 | 0.99 | FALSE |
11 | GTEx | Lung | EDEM3 | 0.15 | 0.10 | lasso | 6 | 0.09 | 1.5e-07 | 5.2 | -5.5 | 4.9e-08 | -0.96 | 0.02 | 0.98 | FALSE |
12 | GTEx | Nerve Tibial | EDEM3 | 0.25 | 0.26 | enet | 20 | 0.28 | 4.8e-20 | 5.5 | -5.5 | 3.1e-08 | -0.99 | 0.01 | 0.99 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | EDEM3 | 0.14 | 0.07 | lasso | 7 | 0.08 | 4.6e-05 | 5.6 | -5.7 | 1.1e-08 | -0.89 | 0.02 | 0.98 | TRUE |
14 | GTEx | Skin Sun Exposed Lower leg | EDEM3 | 0.09 | 0.09 | enet | 12 | 0.10 | 2.1e-08 | 5.6 | -5.5 | 3.7e-08 | -0.95 | 0.01 | 0.99 | FALSE |
15 | GTEx | Testis | EDEM3 | 0.20 | 0.07 | lasso | 7 | 0.08 | 1.3e-04 | 4.2 | -5.2 | 2.0e-07 | -0.94 | 0.03 | 0.97 | FALSE |
16 | GTEx | Thyroid | EDEM3 | 0.11 | 0.07 | enet | 9 | 0.07 | 6.2e-06 | -5.1 | -5.6 | 1.8e-08 | -0.95 | 0.02 | 0.98 | FALSE |
17 | GTEx | Uterus | EDEM3 | 0.27 | 0.02 | enet | 20 | 0.13 | 1.6e-03 | -3.3 | -5.4 | 5.9e-08 | -0.64 | 0.05 | 0.60 | FALSE |
18 | The Cancer Genome Atlas | Colon Adenocarcinoma | EDEM3 | 0.08 | 0.08 | blup | 66 | 0.10 | 1.3e-06 | 5.2 | -5.3 | 1.3e-07 | -0.85 | 0.05 | 0.95 | FALSE |
19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EDEM3 | 0.05 | 0.06 | enet | 7 | 0.08 | 8.7e-10 | 4.2 | -5.2 | 2.1e-07 | -0.83 | 0.13 | 0.87 | FALSE |
20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EDEM3 | 0.04 | 0.06 | lasso | 4 | 0.04 | 7.3e-06 | 5.5 | -5.4 | 5.2e-08 | -0.99 | 0.01 | 0.99 | FALSE |
21 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EDEM3 | 0.02 | 0.02 | blup | 66 | 0.03 | 5.2e-04 | 5.2 | -5.4 | 7.4e-08 | -0.93 | 0.03 | 0.94 | FALSE |
22 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | EDEM3 | 0.05 | 0.05 | blup | 67 | 0.06 | 1.0e-04 | -4.9 | -5.2 | 1.6e-07 | -0.96 | 0.02 | 0.97 | FALSE |
23 | The Cancer Genome Atlas | Rectum Adenocarcinoma | EDEM3 | 0.23 | 0.06 | blup | 67 | 0.03 | 6.3e-02 | -4.9 | -5.3 | 1.1e-07 | -0.85 | 0.01 | 0.54 | FALSE |