Best TWAS P=4.85e-08 · Best GWAS P=3.26e-07 conditioned to 0.00417
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | AHRR | 0.32 | 0.21 | lasso | 4 | 0.18 | 1.6e-05 | 5.0 | 5.1 | 3.0e-07 | 0.93 | 0.01 | 0.88 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CTD-2083E4.5 | 0.09 | 0.07 | lasso | 3 | 0.05 | 1.2e-04 | 5.1 | -5.2 | 2.2e-07 | -0.99 | 0.01 | 0.97 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | CTD-2083E4.5 | 0.25 | 0.11 | enet | 10 | 0.12 | 3.3e-05 | 3.7 | -5.5 | 4.8e-08 | -0.47 | 0.09 | 0.66 | TRUE |
| 4 | GTEx | Pancreas | AC026740.1 | 0.19 | 0.01 | enet | 14 | 0.08 | 3.6e-04 | 2.3 | 5.4 | 5.8e-08 | 0.34 | 0.24 | 0.31 | FALSE |
| 5 | GTEx | Thyroid | CTD-2083E4.5 | 0.07 | 0.06 | lasso | 2 | 0.04 | 3.6e-04 | 5.1 | -5.2 | 2.3e-07 | -0.99 | 0.01 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PDCD6 | 0.03 | 0.02 | blup | 49 | 0.02 | 2.9e-03 | 4.9 | 5.3 | 9.0e-08 | 0.95 | 0.02 | 0.95 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | AHRR | 0.11 | 0.05 | lasso | 3 | 0.07 | 2.5e-04 | 5.0 | 5.2 | 2.4e-07 | 0.86 | 0.01 | 0.90 | FALSE |