Best TWAS P=6.6e-09 · Best GWAS P=2.93e-07 conditioned to 0.223
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | MGMT | 0.39 | 0.25 | lasso | 6 | 0.30 | 1.5e-11 | -4.8 | 5.1 | 2.7e-07 | -0.77 | 0.02 | 0.97 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | MGMT | 0.53 | 0.15 | lasso | 8 | 0.19 | 1.3e-05 | -4.8 | 5.8 | 6.6e-09 | -0.74 | 0.02 | 0.91 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | MGMT | 0.45 | 0.30 | enet | 31 | 0.42 | 4.8e-34 | -4.5 | 5.4 | 6.6e-08 | -0.78 | 0.06 | 0.91 | FALSE |
4 | GTEx | Colon Transverse | MGMT | 0.47 | 0.24 | enet | 58 | 0.35 | 1.6e-17 | -4.6 | 5.2 | 2.5e-07 | -0.60 | 0.05 | 0.92 | FALSE |
5 | GTEx | Esophagus Mucosa | MGMT | 0.41 | 0.33 | enet | 37 | 0.38 | 2.3e-26 | -4.6 | 5.2 | 2.5e-07 | -0.65 | 0.04 | 0.94 | FALSE |
6 | GTEx | Heart Atrial Appendage | MGMT | 0.41 | 0.17 | enet | 33 | 0.22 | 4.6e-10 | -4.6 | 5.4 | 5.6e-08 | -0.77 | 0.03 | 0.96 | FALSE |
7 | GTEx | Prostate | MGMT | 0.25 | 0.13 | lasso | 4 | 0.20 | 9.4e-06 | -4.8 | 5.5 | 4.0e-08 | -0.83 | 0.03 | 0.90 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | MGMT | 0.45 | 0.30 | enet | 42 | 0.46 | 1.6e-41 | -4.5 | 5.3 | 9.1e-08 | -0.73 | 0.04 | 0.94 | FALSE |
9 | GTEx | Stomach | MGMT | 0.33 | 0.20 | enet | 9 | 0.25 | 2.3e-12 | -5.0 | 5.2 | 1.7e-07 | -0.81 | 0.01 | 0.98 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | MGMT | 0.41 | 0.38 | enet | 46 | 0.48 | 3.6e-69 | -4.6 | 5.2 | 1.9e-07 | -0.74 | 0.03 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MGMT | 0.10 | 0.09 | enet | 23 | 0.10 | 1.9e-11 | -4.5 | 5.2 | 2.5e-07 | -0.73 | 0.06 | 0.92 | FALSE |