Best TWAS P=7.11e-15 · Best GWAS P=9.83e-16 conditioned to 1.49e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | POC1B | 0.12 | 0.08 | lasso | 9 | 0.09 | 1.7e-07 | 5.7 | -5.9 | 2.9e-09 | -0.36 | 0.98 | 0.00 | FALSE |
| 2 | GTEx | Adrenal Gland | RP11-981P6.1 | 0.33 | 0.29 | lasso | 3 | 0.19 | 2.2e-07 | 5.7 | 5.7 | 1.1e-08 | 0.29 | 0.99 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | POC1B | 0.13 | 0.06 | enet | 29 | 0.06 | 1.7e-05 | 5.9 | -7.8 | 7.1e-15 | -0.42 | 0.42 | 0.40 | TRUE |
| 4 | GTEx | Artery Tibial | RP11-981P6.1 | 0.07 | 0.06 | lasso | 1 | 0.03 | 1.3e-03 | 5.3 | 5.3 | 1.1e-07 | 0.34 | 0.45 | 0.27 | FALSE |
| 5 | GTEx | Colon Sigmoid | RP11-981P6.1 | 0.19 | 0.12 | lasso | 4 | 0.11 | 9.7e-05 | 5.7 | 5.5 | 3.1e-08 | 0.32 | 0.32 | 0.06 | FALSE |
| 6 | GTEx | Colon Transverse | RP11-981P6.1 | 0.14 | 0.05 | enet | 26 | 0.05 | 1.9e-03 | 5.7 | 5.8 | 9.2e-09 | 0.28 | 0.31 | 0.26 | FALSE |
| 7 | GTEx | Esophagus Muscularis | RP11-981P6.1 | 0.18 | 0.10 | lasso | 3 | 0.06 | 2.9e-04 | 5.7 | 5.6 | 1.9e-08 | 0.32 | 0.86 | 0.07 | FALSE |
| 8 | GTEx | Nerve Tibial | POC1B | 0.30 | 0.18 | lasso | 6 | 0.22 | 1.0e-15 | -4.3 | -5.8 | 6.5e-09 | -0.30 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Spleen | RP11-981P6.1 | 0.28 | 0.18 | lasso | 13 | 0.14 | 2.1e-04 | 5.3 | 5.9 | 4.6e-09 | 0.34 | 0.36 | 0.17 | FALSE |
| 10 | GTEx | Thyroid | RP11-981P6.1 | 0.24 | 0.25 | lasso | 5 | 0.26 | 3.9e-20 | 5.7 | 5.8 | 7.7e-09 | 0.35 | 1.00 | 0.00 | FALSE |
| 11 | METSIM | Adipose | POC1B | 0.07 | 0.03 | bslmm | 381 | 0.03 | 5.2e-05 | 5.7 | -5.4 | 8.3e-08 | -0.39 | 0.92 | 0.00 | FALSE |