Best TWAS P=3.91e-08 · Best GWAS P=1.43e-07 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Breast Mammary Tissue | UPF3A | 0.33 | 0.06 | enet | 18 | 0.18 | 9.7e-10 | -4.8 | -5.1 | 2.9e-07 | 0.67 | 0.03 | 0.96 | FALSE |
2 | GTEx | Breast Mammary Tissue (Female) | UPF3A | 0.32 | 0.16 | lasso | 13 | 0.17 | 1.2e-05 | -4.8 | -5.4 | 6.9e-08 | 0.82 | 0.02 | 0.97 | FALSE |
3 | GTEx | Colon Sigmoid | UPF3A | 0.15 | 0.10 | lasso | 8 | 0.08 | 8.3e-04 | -4.8 | -5.3 | 1.4e-07 | 0.82 | 0.02 | 0.96 | FALSE |
4 | GTEx | Esophagus Muscularis | UPF3A | 0.43 | 0.25 | enet | 33 | 0.37 | 8.8e-24 | -5.2 | -5.2 | 1.5e-07 | 0.79 | 0.00 | 0.99 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDC16 | 0.01 | 0.01 | blup | 49 | 0.01 | 1.1e-03 | -4.7 | -5.3 | 1.1e-07 | 0.71 | 0.03 | 0.90 | FALSE |
6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CDC16 | 0.03 | 0.04 | lasso | 3 | 0.04 | 1.3e-05 | -5.3 | -5.5 | 3.9e-08 | 0.95 | 0.01 | 0.98 | TRUE |
7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CDC16 | 0.07 | 0.03 | blup | 49 | 0.05 | 6.3e-03 | -4.9 | -5.4 | 6.5e-08 | 0.84 | 0.02 | 0.79 | FALSE |
8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | UPF3A | 0.10 | 0.09 | lasso | 1 | 0.08 | 3.8e-04 | -5.2 | -5.2 | 2.4e-07 | 0.93 | 0.00 | 0.81 | FALSE |
9 | The Cancer Genome Atlas | Thyroid Carcinoma | UPF3A | 0.14 | 0.11 | enet | 9 | 0.15 | 1.7e-14 | -5.2 | -5.3 | 1.1e-07 | 0.82 | 0.00 | 0.99 | FALSE |