TWAS
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Models
Genes
Traits
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Traits
:
Trunk fat-free mass
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chr10:22,131,659-23,698,033
Best TWAS P=6.28e-09 · Best GWAS P=4.44e-09 conditioned to 0.136
22.2M
22.4M
22.6M
22.8M
23M
23.2M
23.4M
23.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
PIP4K2A
0.20
0.18
lasso
1
0.18
6.4e-21
5.8
-5.8
6.3e-09
-0.90
0.00
1.00
TRUE
3
GTEx
Cells Transformed fibroblasts
PIP4K2A
0.24
0.20
lasso
2
0.19
2.9e-14
5.4
-5.3
1.2e-07
-0.78
0.05
0.95
FALSE
2
GTEx
Artery Tibial
PIP4K2A
0.06
0.01
enet
8
0.02
2.1e-02
5.4
-5.2
2.2e-07
-0.64
0.09
0.65
FALSE