[Hub]/) : Traits : Trunk fat-free mass :

chr18:11,968,117-13,822,256

Best TWAS P=1.04e-10 · Best GWAS P=2.57e-09 conditioned to 0.885

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CEP192 0.13 0.13 lasso 6 0.14 1.1e-16 5.6 5.6 2.4e-08 0.97 0.04 0.96 FALSE
2 GTEx Adipose Subcutaneous CEP192 0.38 0.44 enet 24 0.48 1.3e-44 5.4 5.4 7.7e-08 0.97 0.06 0.94 FALSE
3 GTEx Adrenal Gland CEP192 0.44 0.56 lasso 2 0.56 9.6e-24 5.4 5.3 1.1e-07 0.96 0.07 0.93 FALSE
4 GTEx Artery Aorta CEP192 0.43 0.50 lasso 11 0.55 2.5e-35 5.5 5.5 2.9e-08 0.97 0.03 0.97 FALSE
5 GTEx Artery Coronary CEP192 0.32 0.35 lasso 5 0.33 8.2e-12 5.6 5.4 7.7e-08 0.97 0.03 0.97 FALSE
6 GTEx Artery Tibial CEP192 0.40 0.50 enet 29 0.54 7.3e-50 5.5 5.5 2.8e-08 0.97 0.04 0.96 FALSE
7 GTEx Brain Caudate basal ganglia CEP192 0.48 0.36 enet 19 0.36 4.2e-11 5.6 5.2 1.7e-07 0.96 0.03 0.97 FALSE
8 GTEx Brain Cerebellar Hemisphere CEP192 0.44 0.20 enet 22 0.26 2.2e-07 5.7 6.0 2.1e-09 0.93 0.03 0.97 FALSE
9 GTEx Brain Cerebellum CEP192 0.52 0.44 enet 31 0.52 5.6e-18 5.6 5.2 1.7e-07 0.92 0.03 0.97 FALSE
10 GTEx Brain Frontal Cortex BA9 SEH1L 0.29 -0.01 lasso 4 0.00 3.0e-01 5.7 5.4 8.1e-08 0.75 0.04 0.37 FALSE
11 GTEx Brain Frontal Cortex BA9 CEP192 0.27 0.19 lasso 11 0.18 1.3e-05 5.7 5.8 5.6e-09 0.93 0.03 0.96 FALSE
12 GTEx Brain Putamen basal ganglia CEP192 0.50 0.39 lasso 5 0.36 2.4e-09 5.6 5.3 9.8e-08 0.95 0.03 0.97 FALSE
13 GTEx Breast Mammary Tissue CEP192 0.38 0.40 lasso 4 0.42 4.7e-23 5.4 5.7 1.5e-08 0.96 0.03 0.97 FALSE
14 GTEx Breast Mammary Tissue (Male) CEP192 0.58 0.26 lasso 11 0.30 1.3e-07 5.5 5.5 3.1e-08 0.95 0.02 0.97 FALSE
15 GTEx Cells EBV-transformed lymphocytes SEH1L 0.18 0.13 lasso 4 0.08 1.3e-03 5.4 5.4 7.7e-08 0.93 0.04 0.73 FALSE
16 GTEx Cells EBV-transformed lymphocytes CEP192 0.52 0.34 lasso 5 0.36 1.6e-12 5.4 5.8 6.3e-09 0.90 0.03 0.97 FALSE
17 GTEx Cells Transformed fibroblasts SEH1L 0.10 0.03 enet 18 0.04 7.8e-04 5.7 5.7 9.4e-09 0.63 0.03 0.95 FALSE
18 GTEx Cells Transformed fibroblasts CEP192 0.32 0.32 enet 39 0.39 2.7e-31 5.6 5.6 2.7e-08 0.93 0.03 0.97 FALSE
19 GTEx Colon Transverse CEP192 0.45 0.54 lasso 8 0.57 1.2e-32 5.4 5.2 2.1e-07 0.96 0.05 0.95 FALSE
20 GTEx Esophagus Gastroesophageal Junction CEP192 0.38 0.39 lasso 4 0.39 4.7e-15 5.4 5.5 2.9e-08 0.97 0.03 0.97 FALSE
21 GTEx Esophagus Mucosa SEH1L 0.09 0.02 enet 25 0.03 2.4e-03 -5.5 5.9 4.1e-09 0.47 0.05 0.86 FALSE
22 GTEx Esophagus Mucosa CEP192 0.39 0.51 enet 29 0.52 7.4e-40 5.5 5.3 1.0e-07 0.97 0.03 0.97 FALSE
23 GTEx Esophagus Muscularis CEP192 0.39 0.46 lasso 9 0.52 2.1e-36 5.6 5.2 1.8e-07 0.97 0.04 0.96 FALSE
24 GTEx Heart Atrial Appendage CEP192 0.29 0.28 lasso 5 0.26 4.3e-12 5.4 5.2 2.5e-07 0.95 0.02 0.98 FALSE
25 GTEx Heart Left Ventricle CEP192 0.24 0.06 lasso 4 0.09 1.4e-05 5.4 5.1 3.0e-07 0.91 0.03 0.97 FALSE
26 GTEx Lung CEP192 0.32 0.29 lasso 7 0.34 3.8e-27 5.4 5.5 4.7e-08 0.96 0.04 0.96 FALSE
27 GTEx Muscle Skeletal CEP192 0.10 0.07 lasso 3 0.07 3.1e-07 5.4 5.2 1.8e-07 0.95 0.03 0.97 FALSE
28 GTEx Nerve Tibial CEP192 0.44 0.52 lasso 12 0.55 3.1e-46 5.6 5.4 6.8e-08 0.97 0.03 0.97 FALSE
29 GTEx Ovary CEP192 0.43 0.42 enet 25 0.43 6.5e-12 5.4 5.5 3.1e-08 0.97 0.02 0.98 FALSE
30 GTEx Pituitary SEH1L 0.22 0.07 lasso 6 0.05 2.1e-02 -5.5 5.2 2.2e-07 0.35 0.06 0.26 FALSE
31 GTEx Prostate CEP192 0.57 0.59 enet 23 0.66 1.8e-21 5.5 5.4 7.5e-08 0.96 0.03 0.97 FALSE
32 GTEx Skin Not Sun Exposed Suprapubic CEP192 0.34 0.35 enet 20 0.40 1.6e-23 5.6 5.1 2.7e-07 0.96 0.03 0.97 FALSE
33 GTEx Skin Sun Exposed Lower leg CEP192 0.34 0.36 lasso 3 0.38 3.5e-33 5.4 5.5 4.9e-08 0.97 0.08 0.92 FALSE
34 GTEx Spleen CEP192 0.54 0.52 lasso 5 0.49 2.8e-14 5.4 5.4 5.5e-08 0.97 0.04 0.96 FALSE
35 GTEx Stomach CEP192 0.37 0.44 lasso 5 0.43 1.5e-22 5.4 5.6 2.3e-08 0.96 0.05 0.95 FALSE
36 GTEx Thyroid CEP192 0.37 0.48 lasso 7 0.52 3.2e-46 5.5 5.6 2.5e-08 0.97 0.04 0.96 FALSE
37 GTEx Uterus CEP192 0.52 0.43 lasso 6 0.41 1.7e-09 5.4 5.5 3.8e-08 0.96 0.03 0.97 FALSE
38 GTEx Vagina CEP192 0.51 0.31 lasso 4 0.37 2.3e-09 5.4 5.3 1.2e-07 0.94 0.03 0.97 FALSE
39 GTEx Whole Blood CEP192 0.17 0.16 enet 15 0.17 3.7e-15 5.4 5.4 8.0e-08 0.97 0.04 0.96 FALSE
40 METSIM Adipose CEP192 0.19 0.32 lasso 5 0.32 1.0e-48 5.4 5.3 1.4e-07 0.96 0.05 0.95 FALSE
41 METSIM Adipose CEP76 0.04 0.00 bslmm 395 0.01 1.8e-02 2.5 5.3 9.3e-08 0.31 0.24 0.03 FALSE
42 The Cancer Genome Atlas Bladder Urothelial Carcinoma CEP192 0.07 0.09 lasso 2 0.09 9.4e-08 6.0 6.0 2.7e-09 1.00 0.01 0.99 FALSE
43 The Cancer Genome Atlas Breast Invasive Carcinoma CEP192 0.06 0.13 enet 9 0.13 3.4e-26 5.6 5.8 8.0e-09 0.97 0.03 0.97 FALSE
44 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CEP192 0.16 0.20 lasso 4 0.19 1.6e-09 5.6 5.6 1.7e-08 0.98 0.02 0.98 FALSE
45 The Cancer Genome Atlas Colon Adenocarcinoma CEP192 0.06 0.05 blup 84 0.04 1.5e-03 5.7 6.5 1.0e-10 0.93 0.02 0.93 TRUE
46 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CEP192 0.21 0.31 lasso 4 0.31 1.0e-35 5.5 5.3 8.7e-08 0.97 0.04 0.96 FALSE
47 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SEH1L 0.03 0.01 blup 60 0.01 4.0e-02 -5.4 5.9 4.7e-09 0.70 0.02 0.45 FALSE
48 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CEP192 0.30 0.33 lasso 2 0.33 1.8e-19 5.4 5.3 9.9e-08 0.95 0.05 0.95 FALSE
49 The Cancer Genome Atlas Brain Lower Grade Glioma CEP192 0.27 0.38 blup 84 0.38 1.5e-45 5.6 5.3 1.3e-07 0.95 0.04 0.96 FALSE
50 The Cancer Genome Atlas Brain Lower Grade Glioma SEH1L 0.05 0.00 blup 60 0.01 1.0e-02 5.4 5.6 2.3e-08 0.74 0.01 0.50 FALSE
51 The Cancer Genome Atlas Liver Hepatocellular Carcinoma CEP192 0.11 0.16 lasso 3 0.16 7.6e-08 6.0 6.1 1.4e-09 0.99 0.02 0.98 FALSE
52 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CEP192 0.09 0.07 blup 84 0.09 2.1e-06 5.2 5.3 1.3e-07 0.92 0.04 0.96 FALSE
53 The Cancer Genome Atlas Pancreatic Adenocarcinoma CEP192 0.12 0.06 blup 84 0.08 2.0e-04 4.6 6.1 9.5e-10 0.95 0.03 0.96 FALSE
54 The Cancer Genome Atlas Prostate Adenocarcinoma CEP192 0.33 0.49 lasso 5 0.49 1.0e-57 5.6 5.6 1.7e-08 0.98 0.02 0.98 FALSE
55 The Cancer Genome Atlas Soft Tissue Sarcoma CEP192 0.10 0.07 blup 84 0.08 1.2e-05 5.4 5.3 1.0e-07 0.96 0.03 0.96 FALSE
56 The Cancer Genome Atlas Thyroid Carcinoma CEP192 0.36 0.53 enet 19 0.54 2.6e-61 5.5 5.5 4.5e-08 0.98 0.02 0.98 FALSE