Hub : Traits :

Chest pain or discomfort

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 15 51548744 53052565 1 1 3.6e-07 9.3e-09 0.00055 64 MAPK6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in father) 4.61 1 0 0 0 1 MAPK6
Major Depression (MDD) 3.94 1 0 0 0 1 MAPK6
Body Mass Index (BMI) (2010) 5.06 1 0 0 0 1 MAPK6
HbA1C 4.21 1 0 0 0 1 MAPK6
BMI 2.42 1 0 0 0 1 MAPK6
Systolic Blood Pressure 0.83 1 0 0 0 1 MAPK6
Smoking Status 1.91 1 0 0 0 1 MAPK6
Respiratory disease 1.92 1 0 0 0 1 MAPK6
Type 2 Diabetes (T2D) 3.32 1 0 0 0 1 MAPK6
Hand grip strength (left) 2.11 1 0 0 0 1 MAPK6
Hearing difficulty/problems: Yes 7.97 1 0 0 0 1 MAPK6
Ever had hysterectomy (womb removed) 4.37 1 0 0 0 1 MAPK6
Medication: Co-codamol 4.81 1 0 0 0 1 MAPK6
Medication: Metformin 6.04 1 0 0 0 1 MAPK6
Diabetes (mother) 6.30 1 0 0 0 1 MAPK6
Impedance of leg (right) 2.41 1 0 0 0 1 MAPK6
Leg fat-free mass (left) 0.98 1 0 0 0 1 MAPK6
Tinnitus: Yes, but not now, but have in the past 6.25 1 0 0 0 1 MAPK6
Medication: Levothyroxine sodium 2.91 1 0 0 0 1 MAPK6
Sitting height 1.31 1 0 0 0 1 MAPK6
Body mass index (BMI) 2.13 1 0 0 0 1 MAPK6
Impedance of leg (left) 3.48 1 0 0 0 1 MAPK6
Leg predicted mass (left) 1.04 1 0 0 0 1 MAPK6
Waist circumference 2.23 1 0 0 0 1 MAPK6
Hearing difficulty/problems with background noise 6.12 1 0 0 0 1 MAPK6
Weight 0.97 1 0 0 0 1 MAPK6
Arm fat percentage (right) 2.83 1 0 0 0 1 MAPK6
Frequency of tiredness / lethargy in last 2 weeks 9.35 1 0 0 0 1 MAPK6
Noisy workplace 11.03 1 0 0 0 1 MAPK6
Qualifications: A levels/AS levels or equivalent 1.74 1 0 0 0 1 MAPK6
Arm fat mass (right) 1.94 1 0 0 0 1 MAPK6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.85 1 0 0 0 1 MAPK6
Hair/balding pattern: Pattern 4 2.81 1 0 0 0 1 MAPK6
Loud music exposure frequency 4.48 1 0 0 0 1 MAPK6
Birth weight 1.79 1 0 0 0 1 MAPK6
Wheeze or whistling in the chest in last year 5.76 1 0 0 0 1 MAPK6
Eye problems/disorders: None of the above 3.88 1 0 0 0 1 MAPK6
Neck or shoulder pain in last month 12.75 1 0 0 0 1 MAPK6
Leg fat mass (right) 1.02 1 0 0 0 1 MAPK6
Pulse rate, automated reading 5.14 1 0 0 0 1 MAPK6
Suffer from 'nerves' 2.44 1 0 0 0 1 MAPK6
Overall health rating 5.58 1 0 0 0 1 MAPK6
Knee pain experienced in last month 2.50 1 0 0 0 1 MAPK6
Leg fat-free mass (right) 0.82 1 0 0 0 1 MAPK6
Arm fat percentage (left) 2.14 1 0 0 0 1 MAPK6
Mood swings 2.22 1 0 0 0 1 MAPK6
Medication: Gliclazide 4.47 1 0 0 0 1 MAPK6
Illnesses of father: None of the above (group 1) 5.41 1 0 0 0 1 MAPK6
Leg predicted mass (right) 0.83 1 0 0 0 1 MAPK6
Arm fat mass (left) 1.64 1 0 0 0 1 MAPK6
Miserableness 3.03 1 0 0 0 1 MAPK6
Guilty feelings 3.43 1 0 0 0 1 MAPK6
High cholesterol (Self-reported) 2.75 1 0 0 0 1 MAPK6
Ever smoked 2.31 1 0 0 0 1 MAPK6
Basal metabolic rate 0.73 1 0 0 0 1 MAPK6
Pain experienced in last month 7.37 1 0 0 0 1 MAPK6
Impedance of whole body 2.27 1 0 0 0 1 MAPK6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.47
GTEx Adipose Visceral Omentum 0 0.0000 1.50
GTEx Adrenal Gland 0 0.0000 1.47
GTEx Artery Aorta 0 0.0000 1.46
GTEx Artery Coronary 0 0.0000 1.53
GTEx Artery Tibial 0 0.0000 1.48
GTEx Brain Caudate basal ganglia 0 0.0000 1.50
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.52
GTEx Brain Cerebellum 0 0.0000 1.54
GTEx Brain Cortex 0 0.0000 1.44
GTEx Brain Frontal Cortex BA9 0 0.0000 1.48
GTEx Brain Hippocampus 0 0.0000 1.46
GTEx Brain Hypothalamus 0 0.0000 1.43
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.56
GTEx Brain Putamen basal ganglia 0 0.0000 1.44
GTEx Breast Mammary Tissue 0 0.0000 1.52
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.52
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.48
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.60
GTEx Cells Transformed fibroblasts 0 0.0000 1.47
GTEx Colon Sigmoid 0 0.0000 1.50
GTEx Colon Transverse 0 0.0000 1.48
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.46
GTEx Esophagus Mucosa 0 0.0000 1.52
GTEx Esophagus Muscularis 0 0.0000 1.49
GTEx Heart Atrial Appendage 0 0.0000 1.44
GTEx Heart Left Ventricle 0 0.0000 1.40
GTEx Liver 0 0.0000 1.41
GTEx Lung 0 0.0000 1.48
GTEx Muscle Skeletal 0 0.0000 1.46
GTEx Nerve Tibial 0 0.0000 1.42
GTEx Ovary 0 0.0000 1.51
GTEx Pancreas 0 0.0000 1.44
GTEx Pituitary 0 0.0000 1.58
GTEx Prostate 0 0.0000 1.46
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.52
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.53
GTEx Small Intestine Terminal Ileum 0 0.0000 1.39
GTEx Spleen 0 0.0000 1.56
GTEx Stomach 0 0.0000 1.46
GTEx Testis 1 0.0317 1.50
GTEx Thyroid 0 0.0000 1.50
GTEx Uterus 0 0.0000 1.49
GTEx Vagina 0 0.0000 1.39
GTEx Whole Blood 0 0.0000 1.49
METSIM Adipose 0 0.0000 1.40
NTR Blood 0 0.0000 1.45
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.43
YFS Blood 0 0.0000 1.41
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.42
TCGA Breast Tumor 0 0.0000 1.63
TCGA Breast Normal 0 0.0000 1.34
TCGA Ovarian Tumor 0 0.0000 1.33
TCGA Prostate Tumor 0 0.0000 1.39