Hub : Traits :

Number of live births

15 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 149347912 150823321 2 1 2.8e-07 7.8e-07 0.41 97 PCMT1
2 11 60549966 62346131 4 2 4.6e-08 1.1e-07 0.48 98 FADS2 PPP1R32

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 4.76 2 0 0.0 0 1 FADS2 PPP1R32
Verbal and Numeric Reasoning (VNR) 2.32 1 0 0.0 0 1 FADS2
Crohns Disease (2012) 5.04 2 0 0.0 0 1 FADS2 PPP1R32
Fasting Glucose 8.50 2 0 0.0 0 1 FADS2 PPP1R32
HDL Cholesterol 16.15 2 2 6.1 0 1 FADS2 PPP1R32
LDL Cholesterol 18.64 2 2 6.1 0 1 FADS2 PPP1R32
Rheumatoid Arthritis 7.18 1 0 0.0 0 1 FADS2
Triglycerides 18.13 2 2 6.1 0 1 FADS2 PPP1R32
Blood Eosinophil Count 7.37 2 2 6.1 0 1 FADS2 PPP1R32
Blood Platelet Count 15.96 2 2 6.1 0 1 FADS2 PPP1R32
Blood Red Count 9.71 3 2 6.1 0 1 FADS2 PCMT1 PPP1R32
Blood White Count 6.10 2 2 6.1 0 1 FADS2 PPP1R32
Heel T-Score 4.01 3 2 6.1 0 1 FADS2 PCMT1 PPP1R32
Height 0.73 1 1 3.0 0 1 FADS2
Waist Hip Ratio (WHR) 1.26 1 0 0.0 0 1 PPP1R32
Hypothyroidism (self reported) 9.30 2 2 6.1 0 1 FADS2 PPP1R32
Respiratory disease 12.25 2 2 6.1 0 1 FADS2 PPP1R32
Lung FVC 0.88 1 0 0.0 0 1 PCMT1
Chronotype (morning person) 3.01 1 0 0.0 0 1 PPP1R32
Hair Pigment 0.86 1 1 3.0 0 1 FADS2
Tanning 0.49 1 0 0.0 0 1 FADS2
Hand grip strength (left) 2.04 1 0 0.0 0 1 PCMT1
Number of treatments/medications taken 5.29 1 0 0.0 0 1 FADS2
Sensitivity / hurt feelings 2.50 1 0 0.0 0 1 PCMT1
Vitamin and mineral supplements 3.29 1 0 0.0 0 1 FADS2
Hand grip strength (right) 2.02 1 0 0.0 0 1 PCMT1
Townsend deprivation index at recruitment 5.53 1 0 0.0 0 1 PCMT1
Maternal smoking around birth 3.49 1 0 0.0 0 1 FADS2
Taking other prescription medications 4.23 1 0 0.0 0 1 FADS2
Heel bone mineral density (BMD) T-score, automated (left) 7.03 2 1 3.0 0 1 FADS2 PPP1R32
Medication: Levothyroxine sodium 9.50 2 1 3.0 0 1 FADS2 PPP1R32
Sitting height 0.85 1 0 0.0 0 1 FADS2
Forced vital capacity (FVC) 1.46 1 0 0.0 0 1 FADS2
Heel bone mineral density (BMD) T-score, automated (right) 8.24 2 1 3.0 0 1 FADS2 PPP1R32
Ever unenthusiastic/disinterested for a whole week 6.83 2 0 0.0 0 1 FADS2 PPP1R32
Allergy 5.64 2 0 0.0 0 1 FADS2 PPP1R32
Medication: Simvastatin 5.60 2 0 0.0 0 1 FADS2 PPP1R32
Fluid intelligence score 2.32 1 0 0.0 0 1 FADS2
Forced expiratory volume in 1-second (FEV1) 1.55 1 0 0.0 0 1 FADS2
Pulse rate 5.80 2 0 0.0 0 1 FADS2 PPP1R32
Asthma 10.69 2 1 3.0 0 1 FADS2 PPP1R32
Standing height 1.18 1 1 3.0 0 1 FADS2
Exposure to tobacco smoke at home 3.43 1 0 0.0 0 1 FADS2
Tense / 'highly strung' 2.51 1 0 0.0 0 1 PPP1R32
Seen doctor (GP) for nerves, anxiety, tension or depression 5.74 2 0 0.0 0 1 FADS2 PPP1R32
Hair/balding pattern: Pattern 4 4.29 2 0 0.0 0 1 FADS2 PPP1R32
Headache pain in last month 3.60 1 0 0.0 0 1 FADS2
Gout (self-reported) 4.37 1 0 0.0 0 1 FADS2
Hypothyroidism/myxoedema (self-reported) 7.10 2 0 0.0 0 1 FADS2 PPP1R32
Number of full brothers 4.12 1 0 0.0 0 1 PCMT1
Seen a psychiatrist for nerves, anxiety, tension or depression 4.58 1 0 0.0 0 1 FADS2
Wheeze or whistling in the chest in last year 5.55 2 0 0.0 0 1 FADS2 PPP1R32
Number of children fathered 4.61 1 0 0.0 0 1 FADS2
Age at first live birth 2.23 1 0 0.0 0 1 PCMT1
Mouth/teeth dental problems: Loose teeth 4.54 1 0 0.0 0 1 PCMT1
Medication: Allopurinol 3.59 1 0 0.0 0 1 FADS2
Pulse rate, automated reading 12.78 2 2 6.1 0 1 FADS2 PPP1R32
Qualifications: NVQ or HND or HNC or equivalent 4.21 1 0 0.0 0 1 FADS2
Knee pain experienced in last month 2.90 1 0 0.0 0 1 PCMT1
Forced expiratory volume in 1-second (FEV1), predicted 2.20 1 0 0.0 0 1 FADS2
Long-standing illness, disability or infirmity 3.63 1 0 0.0 0 1 FADS2
Mineral and other dietary supplements 3.50 1 0 0.0 0 1 FADS2
Asthma (self-reported) 11.54 2 2 6.1 0 1 FADS2 PPP1R32
Osteoporosis (self-reported) 6.29 1 0 0.0 0 1 FADS2
Number of self-reported non-cancer illnesses 3.87 1 0 0.0 0 1 FADS2
Average weekly champagne plus white wine intake 5.38 1 0 0.0 0 1 FADS2
Pain type(s) experienced in last month: Hip pain 4.22 1 0 0.0 0 1 PCMT1
Supplements: Fish oil (including cod liver oil) 5.01 2 0 0.0 0 1 FADS2 PPP1R32
High cholesterol (Self-reported) 5.02 2 0 0.0 0 1 FADS2 PPP1R32
Average weekly beer plus cider intake 3.56 1 0 0.0 0 1 PCMT1
Irritability 4.94 2 0 0.0 0 1 FADS2 PPP1R32
Myopia 4.73 1 0 0.0 0 1 FADS2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.37
GTEx Adipose Visceral Omentum 0 0.0000 1.43
GTEx Adrenal Gland 0 0.0000 1.39
GTEx Artery Aorta 0 0.0000 1.43
GTEx Artery Coronary 0 0.0000 1.61
GTEx Artery Tibial 1 0.0266 1.42
GTEx Brain Caudate basal ganglia 0 0.0000 1.48
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.57
GTEx Brain Cerebellum 1 0.0505 1.56
GTEx Brain Cortex 0 0.0000 1.53
GTEx Brain Frontal Cortex BA9 0 0.0000 1.53
GTEx Brain Hippocampus 0 0.0000 1.41
GTEx Brain Hypothalamus 0 0.0000 1.51
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.51
GTEx Brain Putamen basal ganglia 0 0.0000 1.42
GTEx Breast Mammary Tissue 0 0.0000 1.45
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.45
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.47
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.46
GTEx Cells Transformed fibroblasts 0 0.0000 1.39
GTEx Colon Sigmoid 0 0.0000 1.56
GTEx Colon Transverse 1 0.0484 1.43
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.54
GTEx Esophagus Mucosa 0 0.0000 1.42
GTEx Esophagus Muscularis 0 0.0000 1.43
GTEx Heart Atrial Appendage 0 0.0000 1.60
GTEx Heart Left Ventricle 0 0.0000 1.49
GTEx Liver 0 0.0000 1.36
GTEx Lung 1 0.0348 1.51
GTEx Muscle Skeletal 0 0.0000 1.44
GTEx Nerve Tibial 0 0.0000 1.39
GTEx Ovary 0 0.0000 1.58
GTEx Pancreas 1 0.0613 1.51
GTEx Pituitary 0 0.0000 1.49
GTEx Prostate 0 0.0000 1.51
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.50
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.43
GTEx Small Intestine Terminal Ileum 0 0.0000 1.60
GTEx Spleen 0 0.0000 1.46
GTEx Stomach 0 0.0000 1.50
GTEx Testis 1 0.0317 1.44
GTEx Thyroid 0 0.0000 1.47
GTEx Uterus 1 0.1764 1.65
GTEx Vagina 0 0.0000 1.54
GTEx Whole Blood 1 0.0502 1.47
METSIM Adipose 1 0.0217 1.34
NTR Blood 1 0.0416 1.40
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.41
YFS Blood 3 0.0650 1.38
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.34
TCGA Breast Tumor 0 0.0000 1.30
TCGA Breast Normal 0 0.0000 1.34
TCGA Ovarian Tumor 0 0.0000 1.26
TCGA Prostate Tumor 1 0.0289 1.38