Hub : Traits :

Happiness

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 20 47197520 48603940 1 1 3.9e-07 7e-06 0.17 91 ZFAS1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in father) 8.63 1 0 0 0 1 ZFAS1
Alzheimer’s Disease (including proxy) 3.84 1 0 0 0 1 ZFAS1
Ulcerative Colitis (UC) 2.26 1 0 0 0 1 ZFAS1
Major Depression (MDD) 3.23 1 0 0 0 1 ZFAS1
Reaction Time 6.65 1 0 0 0 1 ZFAS1
Verbal and Numeric Reasoning (VNR) 8.39 1 0 0 0 1 ZFAS1
Body Mass Index (BMI) (2010) 8.43 1 0 0 0 1 ZFAS1
Fasting Glucose 3.44 1 0 0 0 1 ZFAS1
Schizophrenia 3.39 1 0 0 0 1 ZFAS1
Blood Eosinophil Count 0.56 1 0 0 0 1 ZFAS1
Blood Platelet Count 0.34 1 0 0 0 1 ZFAS1
Blood Red Count 1.79 1 0 0 0 1 ZFAS1
BMI 4.65 1 1 3 0 1 ZFAS1
Height 5.82 1 1 3 0 1 ZFAS1
Systolic Blood Pressure 5.97 1 1 3 0 1 ZFAS1
Allergy or Eczema 1.73 1 0 0 0 1 ZFAS1
Respiratory disease 4.03 1 0 0 0 1 ZFAS1
Lung FEV1/FVC ratio 3.93 1 0 0 0 1 ZFAS1
Lung FVC 4.27 1 0 0 0 1 ZFAS1
Neuroticism 1.83 1 0 0 0 1 ZFAS1
Hair Pigment 0.48 1 0 0 0 1 ZFAS1
Tanning 0.37 1 0 0 0 1 ZFAS1
Hand grip strength (left) 2.37 1 0 0 0 1 ZFAS1
Frequency of depressed mood in last 2 weeks 18.31 1 1 3 0 1 ZFAS1
Systolic blood pressure, automated reading 4.12 1 0 0 0 1 ZFAS1
Trunk fat percentage 4.15 1 0 0 0 1 ZFAS1
Hand grip strength (right) 2.99 1 0 0 0 1 ZFAS1
Frequency of unenthusiasm / disinterest in last 2 weeks 6.05 1 0 0 0 1 ZFAS1
High blood pressure 1.93 1 0 0 0 1 ZFAS1
Sitting height 6.46 1 1 3 0 1 ZFAS1
High blood pressure (mother) 4.15 1 0 0 0 1 ZFAS1
Body mass index (BMI) 4.85 1 0 0 0 1 ZFAS1
Trunk fat mass 1.87 1 0 0 0 1 ZFAS1
Waist circumference 1.45 1 0 0 0 1 ZFAS1
Nervous feelings 2.43 1 0 0 0 1 ZFAS1
Frequency of tenseness / restlessness in last 2 weeks 8.02 1 0 0 0 1 ZFAS1
Hearing difficulty/problems with background noise 8.91 1 0 0 0 1 ZFAS1
Forced vital capacity (FVC) 13.53 1 1 3 0 1 ZFAS1
Ever unenthusiastic/disinterested for a whole week 4.64 1 0 0 0 1 ZFAS1
Qualifications: None of the above 4.77 1 0 0 0 1 ZFAS1
Heart attack 6.80 1 0 0 0 1 ZFAS1
Fluid intelligence score 2.87 1 0 0 0 1 ZFAS1
Neuroticism score 1.88 1 0 0 0 1 ZFAS1
Arm fat percentage (right) 7.37 1 1 3 0 1 ZFAS1
Trunk fat-free mass 2.29 1 0 0 0 1 ZFAS1
Worrier / anxious feelings 2.15 1 0 0 0 1 ZFAS1
Frequency of tiredness / lethargy in last 2 weeks 11.54 1 0 0 0 1 ZFAS1
Falls in the last year 3.13 1 0 0 0 1 ZFAS1
Forced expiratory volume in 1-second (FEV1) 6.65 1 0 0 0 1 ZFAS1
Qualifications: A levels/AS levels or equivalent 4.98 1 0 0 0 1 ZFAS1
Asthma 4.06 1 0 0 0 1 ZFAS1
Prospective memory result 3.40 1 0 0 0 1 ZFAS1
Forced expiratory volume in 1-second (FEV1), Best measure 7.22 1 0 0 0 1 ZFAS1
Arm fat mass (right) 2.79 1 0 0 0 1 ZFAS1
Trunk predicted mass 2.28 1 0 0 0 1 ZFAS1
Standing height 7.14 1 1 3 0 1 ZFAS1
Tense / 'highly strung' 6.54 1 0 0 0 1 ZFAS1
Birth weight of first child 9.43 1 0 0 0 1 ZFAS1
Ever highly irritable/argumentative for 2 days 4.63 1 0 0 0 1 ZFAS1
Qualifications: O levels/GCSEs or equivalent 8.75 1 0 0 0 1 ZFAS1
Glaucoma (self-reported) 3.38 1 0 0 0 1 ZFAS1
Birth weight 2.43 1 0 0 0 1 ZFAS1
Forced vital capacity (FVC), Best measure 13.89 1 1 3 0 1 ZFAS1
Body fat percentage 6.19 1 0 0 0 1 ZFAS1
Leg fat percentage (right) 8.11 1 1 3 0 1 ZFAS1
Arm fat-free mass (right) 1.19 1 0 0 0 1 ZFAS1
Number of children fathered 12.56 1 0 0 0 1 ZFAS1
Qualifications: College or University degree 3.94 1 0 0 0 1 ZFAS1
Medication: Blood pressure 3.04 1 0 0 0 1 ZFAS1
Mean time to correctly identify matches 7.00 1 0 0 0 1 ZFAS1
Heart disease (mother) 3.50 1 0 0 0 1 ZFAS1
Whole body fat mass 2.45 1 0 0 0 1 ZFAS1
Leg fat mass (right) 3.53 1 0 0 0 1 ZFAS1
Arm predicted mass (right) 1.10 1 0 0 0 1 ZFAS1
Comparative height size at age 10 11.75 1 1 3 0 1 ZFAS1
Family relationship satisfaction 19.48 1 0 0 0 1 ZFAS1
Supplements: Vitamin C 4.72 1 0 0 0 1 ZFAS1
Forced expiratory volume in 1-second (FEV1), predicted 2.34 1 0 0 0 1 ZFAS1
Whole body fat-free mass 1.44 1 0 0 0 1 ZFAS1
Leg fat-free mass (right) 0.78 1 0 0 0 1 ZFAS1
Arm fat percentage (left) 7.26 1 1 3 0 1 ZFAS1
Loneliness, isolation 13.39 1 0 0 0 1 ZFAS1
Friendships satisfaction 8.52 1 0 0 0 1 ZFAS1
Mouth/teeth dental problems: Mouth ulcers 2.64 1 0 0 0 1 ZFAS1
Medication for cholesterol 3.83 1 0 0 0 1 ZFAS1
Mineral and other dietary supplements 3.53 1 0 0 0 1 ZFAS1
Asthma (self-reported) 3.26 1 0 0 0 1 ZFAS1
Osteoporosis (self-reported) 3.54 1 0 0 0 1 ZFAS1
Whole body water mass 1.39 1 0 0 0 1 ZFAS1
Leg predicted mass (right) 0.82 1 0 0 0 1 ZFAS1
Arm fat mass (left) 2.84 1 0 0 0 1 ZFAS1
Average weekly champagne plus white wine intake 7.59 1 0 0 0 1 ZFAS1
Miserableness 3.24 1 0 0 0 1 ZFAS1
Basal metabolic rate 0.83 1 0 0 0 1 ZFAS1
Leg fat percentage (left) 8.50 1 1 3 0 1 ZFAS1
Arm fat-free mass (left) 0.95 1 0 0 0 1 ZFAS1
Average weekly beer plus cider intake 3.05 1 0 0 0 1 ZFAS1
Irritability 4.99 1 0 0 0 1 ZFAS1
Diastolic blood pressure, automated reading 3.28 1 0 0 0 1 ZFAS1
Ever depressed for a whole week 5.88 1 0 0 0 1 ZFAS1
Myopia 3.67 1 0 0 0 1 ZFAS1
Vascular/heart problems diagnosed by doctor 2.29 1 0 0 0 1 ZFAS1
Heart attack/myocardial infarction (self-reported) 5.09 1 0 0 0 1 ZFAS1
Leg fat mass (left) 3.70 1 0 0 0 1 ZFAS1
Arm predicted mass (left) 0.94 1 0 0 0 1 ZFAS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.25
GTEx Adipose Visceral Omentum 0 0.0000 1.24
GTEx Adrenal Gland 0 0.0000 1.23
GTEx Artery Aorta 0 0.0000 1.26
GTEx Artery Coronary 0 0.0000 1.23
GTEx Artery Tibial 0 0.0000 1.23
GTEx Brain Caudate basal ganglia 0 0.0000 1.16
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.15
GTEx Brain Cerebellum 0 0.0000 1.20
GTEx Brain Cortex 0 0.0000 1.28
GTEx Brain Frontal Cortex BA9 0 0.0000 1.18
GTEx Brain Hippocampus 0 0.0000 1.27
GTEx Brain Hypothalamus 0 0.0000 1.20
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.17
GTEx Brain Putamen basal ganglia 0 0.0000 1.25
GTEx Breast Mammary Tissue 0 0.0000 1.19
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.23
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.25
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.28
GTEx Cells Transformed fibroblasts 0 0.0000 1.20
GTEx Colon Sigmoid 0 0.0000 1.21
GTEx Colon Transverse 0 0.0000 1.19
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.21
GTEx Esophagus Mucosa 0 0.0000 1.24
GTEx Esophagus Muscularis 0 0.0000 1.26
GTEx Heart Atrial Appendage 0 0.0000 1.22
GTEx Heart Left Ventricle 0 0.0000 1.24
GTEx Liver 0 0.0000 1.26
GTEx Lung 0 0.0000 1.25
GTEx Muscle Skeletal 0 0.0000 1.23
GTEx Nerve Tibial 0 0.0000 1.23
GTEx Ovary 0 0.0000 1.25
GTEx Pancreas 0 0.0000 1.23
GTEx Pituitary 0 0.0000 1.19
GTEx Prostate 0 0.0000 1.30
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.29
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.27
GTEx Small Intestine Terminal Ileum 0 0.0000 1.29
GTEx Spleen 0 0.0000 1.24
GTEx Stomach 0 0.0000 1.23
GTEx Testis 0 0.0000 1.29
GTEx Thyroid 0 0.0000 1.27
GTEx Uterus 0 0.0000 1.16
GTEx Vagina 0 0.0000 1.19
GTEx Whole Blood 0 0.0000 1.25
METSIM Adipose 0 0.0000 1.24
NTR Blood 0 0.0000 1.23
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.28
YFS Blood 0 0.0000 1.20
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.22
TCGA Breast Tumor 0 0.0000 1.11
TCGA Breast Normal 0 0.0000 1.18
TCGA Ovarian Tumor 0 0.0000 1.10
TCGA Prostate Tumor 0 0.0000 1.19