Hub : Traits :

Health satisfaction

4 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 1421531 2761863 1 1 1.2e-07 1.5e-05 0.51 98 C1orf86
2 1 201164764 202607593 2 1 1.4e-07 5.4e-08 1.00 100 LMOD1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Verbal and Numeric Reasoning (VNR) 2.86 1 0 0 0 1 LMOD1
Age at First Birth 2.51 1 0 0 0 1 LMOD1
Body Mass Index (BMI) (2010) 10.47 1 0 0 0 1 LMOD1
Coronary Artery Disease (CAD) 11.10 1 0 0 0 1 LMOD1
Rheumatoid Arthritis 3.07 1 0 0 0 1 C1orf86
Blood Eosinophil Count 0.64 1 0 0 0 1 C1orf86
Blood Platelet Count 0.94 1 0 0 0 1 C1orf86
Blood Red Count 0.51 1 0 0 0 1 LMOD1
Heel T-Score 0.54 1 0 0 0 1 LMOD1
BMI 11.18 1 1 3 0 1 LMOD1
Height 1.27 1 1 3 0 1 C1orf86
Waist Hip Ratio (WHR) 0.95 1 0 0 0 1 LMOD1
Systolic Blood Pressure 2.69 1 0 0 0 1 C1orf86
Smoking Status 1.85 1 0 0 0 1 LMOD1
Cardiovascular Disease 4.44 2 0 0 0 1 C1orf86 LMOD1
Hypothyroidism (self reported) 1.81 1 0 0 0 1 LMOD1
Lung FEV1/FVC ratio 1.84 1 0 0 0 1 LMOD1
Neuroticism 1.81 1 0 0 0 1 LMOD1
Chronotype (morning person) 3.89 1 0 0 0 1 LMOD1
Number of treatments/medications taken 2.68 1 0 0 0 1 LMOD1
Frequency of depressed mood in last 2 weeks 2.50 1 0 0 0 1 LMOD1
Ever had hysterectomy (womb removed) 5.53 1 0 0 0 1 LMOD1
Systolic blood pressure, automated reading 2.48 1 0 0 0 1 C1orf86
Medication: Metformin 2.93 1 0 0 0 1 LMOD1
Impedance of leg (right) 5.71 2 1 3 0 1 C1orf86 LMOD1
Leg fat-free mass (left) 6.48 2 1 3 0 1 C1orf86 LMOD1
Trunk fat percentage 5.99 1 1 3 0 1 LMOD1
Hand grip strength (right) 2.00 1 0 0 0 1 LMOD1
Townsend deprivation index at recruitment 2.78 1 0 0 0 1 LMOD1
Current tobacco smoking 2.62 1 0 0 0 1 LMOD1
Maternal smoking around birth 3.13 1 0 0 0 1 C1orf86
Frequency of unenthusiasm / disinterest in last 2 weeks 3.34 1 0 0 0 1 LMOD1
High blood pressure 5.79 2 0 0 0 1 C1orf86 LMOD1
Hayfever, allergic rhinitis or eczema 2.27 1 0 0 0 1 LMOD1
Medication: Levothyroxine sodium 2.58 1 0 0 0 1 LMOD1
Sitting height 2.06 1 0 0 0 1 C1orf86
Body mass index (BMI) 12.50 1 1 3 0 1 LMOD1
Impedance of leg (left) 6.33 2 1 3 0 1 C1orf86 LMOD1
Leg predicted mass (left) 6.44 2 1 3 0 1 C1orf86 LMOD1
Trunk fat mass 7.78 1 1 3 0 1 LMOD1
Waist circumference 8.42 1 1 3 0 1 LMOD1
Number of incorrect matches in round 5.33 1 0 0 0 1 LMOD1
Alcohol usually taken with meals 5.08 1 0 0 0 1 LMOD1
Forced vital capacity (FVC) 1.06 1 0 0 0 1 C1orf86
Qualifications: None of the above 2.64 1 0 0 0 1 LMOD1
Hayfever/allergic rhinitis (self-reported) 3.76 1 0 0 0 1 C1orf86
Fluid intelligence score 4.34 1 0 0 0 1 LMOD1
Weight 8.78 1 1 3 0 1 LMOD1
Impedance of arm (right) 5.99 1 1 3 0 1 LMOD1
Arm fat percentage (right) 8.52 1 1 3 0 1 LMOD1
Trunk fat-free mass 5.32 2 1 3 0 1 C1orf86 LMOD1
Hip circumference 6.99 1 1 3 0 1 LMOD1
Father's age at death 3.02 1 0 0 0 1 C1orf86
Frequency of tiredness / lethargy in last 2 weeks 6.80 1 0 0 0 1 LMOD1
Number of live births 2.59 1 0 0 0 1 LMOD1
Forced expiratory volume in 1-second (FEV1) 1.22 1 0 0 0 1 C1orf86
Pulse rate 3.41 1 0 0 0 1 LMOD1
Noisy workplace 7.40 1 0 0 0 1 LMOD1
Qualifications: A levels/AS levels or equivalent 2.72 1 0 0 0 1 LMOD1
Illnesses of mother 5.65 1 0 0 0 1 C1orf86
Forced expiratory volume in 1-second (FEV1), Best measure 1.64 1 0 0 0 1 C1orf86
Impedance of arm (left) 7.04 1 1 3 0 1 LMOD1
Arm fat mass (right) 10.84 1 1 3 0 1 LMOD1
Trunk predicted mass 5.30 2 1 3 0 1 C1orf86 LMOD1
Standing height 1.46 1 1 3 0 1 C1orf86
Qualifications: O levels/GCSEs or equivalent 2.84 1 0 0 0 1 LMOD1
Medication: Paracetamol 2.60 1 0 0 0 1 LMOD1
Hypothyroidism/myxoedema (self-reported) 2.24 1 0 0 0 1 LMOD1
Forced vital capacity (FVC), Best measure 1.52 1 0 0 0 1 C1orf86
Body fat percentage 7.24 1 1 3 0 1 LMOD1
Leg fat percentage (right) 8.89 1 1 3 0 1 LMOD1
Arm fat-free mass (right) 6.10 2 1 3 0 1 C1orf86 LMOD1
Exposure to tobacco smoke outside home 3.46 1 0 0 0 1 C1orf86
Comparative body size at age 10 3.55 1 0 0 0 1 LMOD1
Wheeze or whistling in the chest in last year 4.52 1 0 0 0 1 LMOD1
Age at first live birth 3.54 1 0 0 0 1 LMOD1
Shortness of breath walking on level ground 9.15 1 0 0 0 1 LMOD1
Qualifications: College or University degree 3.98 1 0 0 0 1 LMOD1
Medication for pain relief, constipation, heartburn 6.07 1 0 0 0 1 LMOD1
Medication: Blood pressure 2.71 1 0 0 0 1 C1orf86
Whole body fat mass 9.25 1 1 3 0 1 LMOD1
Leg fat mass (right) 10.94 1 1 3 0 1 LMOD1
Arm predicted mass (right) 6.36 2 1 3 0 1 C1orf86 LMOD1
Pulse rate, automated reading 4.99 1 1 3 0 1 LMOD1
Alcohol intake frequency. 2.17 1 0 0 0 1 LMOD1
Comparative height size at age 10 1.08 1 0 0 0 1 C1orf86
Overall health rating 9.60 1 1 3 0 1 LMOD1
Medication: Aspirin 5.12 1 0 0 0 1 LMOD1
Hypertension (Self-reported) 5.76 2 0 0 0 1 C1orf86 LMOD1
Illnesses of father: Heart disease 3.90 1 0 0 0 1 LMOD1
Whole body fat-free mass 5.87 2 1 3 0 1 C1orf86 LMOD1
Leg fat-free mass (right) 5.60 2 1 3 0 1 C1orf86 LMOD1
Arm fat percentage (left) 8.03 1 1 3 0 1 LMOD1
Average weekly red wine intake 3.01 1 0 0 0 1 LMOD1
Loneliness, isolation 2.86 1 0 0 0 1 LMOD1
Qualifications: nursing, teaching 8.77 1 1 3 0 1 LMOD1
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.22 1 0 0 0 1 LMOD1
Medication: Aspirin 5.56 1 0 0 0 1 LMOD1
Illnesses of father: None of the above (group 1) 5.68 1 0 0 0 1 LMOD1
Smoking status: Current 3.00 1 0 0 0 1 LMOD1
Whole body water mass 5.92 2 1 3 0 1 C1orf86 LMOD1
Leg predicted mass (right) 5.57 2 1 3 0 1 C1orf86 LMOD1
Arm fat mass (left) 10.34 1 1 3 0 1 LMOD1
Miserableness 3.09 1 0 0 0 1 LMOD1
Ever taken oral contraceptive pill 4.25 1 0 0 0 1 LMOD1
Medication: Blood pressure 4.68 2 0 0 0 1 C1orf86 LMOD1
Basal metabolic rate 6.57 2 1 3 0 1 C1orf86 LMOD1
Leg fat percentage (left) 9.14 1 1 3 0 1 LMOD1
Arm fat-free mass (left) 7.21 2 1 3 0 1 C1orf86 LMOD1
Diastolic blood pressure, automated reading 6.31 1 1 3 0 1 LMOD1
Vascular/heart problems diagnosed by doctor 6.12 2 0 0 0 1 C1orf86 LMOD1
Pain experienced in last month 2.46 1 0 0 0 1 LMOD1
Heart attack/myocardial infarction (self-reported) 2.87 1 0 0 0 1 LMOD1
Alcohol drinker status: Previous 3.14 1 0 0 0 1 C1orf86
Impedance of whole body 6.81 1 1 3 0 1 LMOD1
Leg fat mass (left) 10.92 1 1 3 0 1 LMOD1
Arm predicted mass (left) 6.89 2 1 3 0 1 C1orf86 LMOD1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.33
GTEx Adipose Visceral Omentum 0 0.0000 1.35
GTEx Adrenal Gland 0 0.0000 1.29
GTEx Artery Aorta 0 0.0000 1.35
GTEx Artery Coronary 0 0.0000 1.30
GTEx Artery Tibial 0 0.0000 1.36
GTEx Brain Caudate basal ganglia 0 0.0000 1.32
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.25
GTEx Brain Cerebellum 0 0.0000 1.32
GTEx Brain Cortex 0 0.0000 1.31
GTEx Brain Frontal Cortex BA9 0 0.0000 1.27
GTEx Brain Hippocampus 0 0.0000 1.19
GTEx Brain Hypothalamus 0 0.0000 1.19
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.14
GTEx Brain Putamen basal ganglia 0 0.0000 1.28
GTEx Breast Mammary Tissue 0 0.0000 1.34
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.26
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.27
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.41
GTEx Cells Transformed fibroblasts 0 0.0000 1.33
GTEx Colon Sigmoid 0 0.0000 1.35
GTEx Colon Transverse 0 0.0000 1.31
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.37
GTEx Esophagus Mucosa 0 0.0000 1.32
GTEx Esophagus Muscularis 2 0.0619 1.38
GTEx Heart Atrial Appendage 0 0.0000 1.34
GTEx Heart Left Ventricle 0 0.0000 1.28
GTEx Liver 0 0.0000 1.29
GTEx Lung 0 0.0000 1.36
GTEx Muscle Skeletal 0 0.0000 1.35
GTEx Nerve Tibial 0 0.0000 1.35
GTEx Ovary 0 0.0000 1.33
GTEx Pancreas 0 0.0000 1.27
GTEx Pituitary 0 0.0000 1.20
GTEx Prostate 0 0.0000 1.34
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.34
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.30
GTEx Small Intestine Terminal Ileum 0 0.0000 1.43
GTEx Spleen 0 0.0000 1.40
GTEx Stomach 0 0.0000 1.25
GTEx Testis 0 0.0000 1.36
GTEx Thyroid 0 0.0000 1.32
GTEx Uterus 0 0.0000 1.20
GTEx Vagina 0 0.0000 1.33
GTEx Whole Blood 0 0.0000 1.38
METSIM Adipose 1 0.0217 1.27
NTR Blood 0 0.0000 1.27
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.32
YFS Blood 0 0.0000 1.26
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.32
TCGA Breast Tumor 1 0.1304 1.30
TCGA Breast Normal 0 0.0000 1.25
TCGA Ovarian Tumor 0 0.0000 1.21
TCGA Prostate Tumor 0 0.0000 1.26