Hub : Traits :

Friendships satisfaction

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 139232299 140571526 1 1 2.8e-07 1.1e-05 0.019 71 SRA1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 5.34 1 0 0 0 1 SRA1
Reaction Time 2.58 1 0 0 0 1 SRA1
Verbal and Numeric Reasoning (VNR) 9.01 1 0 0 0 1 SRA1
Bipolar Disorder 10.99 1 0 0 0 1 SRA1
Neuroticism 8.94 1 0 0 0 1 SRA1
Triglycerides 2.44 1 0 0 0 1 SRA1
Blood Red Count 0.61 1 0 0 0 1 SRA1
Blood White Count 1.11 1 0 0 0 1 SRA1
Heel T-Score 0.75 1 0 0 0 1 SRA1
BMI 1.87 1 0 0 0 1 SRA1
Height 0.35 1 0 0 0 1 SRA1
Systolic Blood Pressure 7.83 1 1 3 0 1 SRA1
Respiratory disease 5.80 1 0 0 0 1 SRA1
Lung FVC 4.37 1 0 0 0 1 SRA1
Neuroticism 9.30 1 0 0 0 1 SRA1
Tanning 0.79 1 0 0 0 1 SRA1
Frequency of depressed mood in last 2 weeks 8.55 1 0 0 0 1 SRA1
Systolic blood pressure, automated reading 1.67 1 0 0 0 1 SRA1
Supplements: Zinc 5.34 1 0 0 0 1 SRA1
Impedance of leg (right) 2.03 1 0 0 0 1 SRA1
Townsend deprivation index at recruitment 2.92 1 0 0 0 1 SRA1
Fed-up feelings 7.87 1 0 0 0 1 SRA1
Frequency of unenthusiasm / disinterest in last 2 weeks 6.08 1 0 0 0 1 SRA1
Medication: Atenolol 5.29 1 0 0 0 1 SRA1
Body mass index (BMI) 0.93 1 0 0 0 1 SRA1
Impedance of leg (left) 2.09 1 0 0 0 1 SRA1
Past tobacco smoking 2.30 1 0 0 0 1 SRA1
Alcohol usually taken with meals 2.90 1 0 0 0 1 SRA1
Frequency of tenseness / restlessness in last 2 weeks 10.24 1 0 0 0 1 SRA1
Forced vital capacity (FVC) 1.03 1 0 0 0 1 SRA1
Ever unenthusiastic/disinterested for a whole week 10.62 1 0 0 0 1 SRA1
Qualifications: None of the above 6.14 1 0 0 0 1 SRA1
Financial difficulties in last 2 years 3.97 1 0 0 0 1 SRA1
Medication: Ramipril 3.23 1 0 0 0 1 SRA1
Fluid intelligence score 3.99 1 0 0 0 1 SRA1
Neuroticism score 8.14 1 0 0 0 1 SRA1
Impedance of arm (right) 1.15 1 0 0 0 1 SRA1
Frequency of tiredness / lethargy in last 2 weeks 4.96 1 0 0 0 1 SRA1
Falls in the last year 5.50 1 0 0 0 1 SRA1
Happiness 6.67 1 0 0 0 1 SRA1
Asthma 4.28 1 0 0 0 1 SRA1
Forced expiratory volume in 1-second (FEV1), Best measure 1.49 1 0 0 0 1 SRA1
Standing height 0.53 1 0 0 0 1 SRA1
Tense / 'highly strung' 5.00 1 0 0 0 1 SRA1
Seen doctor (GP) for nerves, anxiety, tension or depression 6.85 1 0 0 0 1 SRA1
Hair/balding pattern: Pattern 4 4.64 1 0 0 0 1 SRA1
Forced vital capacity (FVC), Best measure 1.72 1 0 0 0 1 SRA1
Worry too long after embarrassment 5.58 1 0 0 0 1 SRA1
Wheeze or whistling in the chest in last year 4.93 1 0 0 0 1 SRA1
Qualifications: College or University degree 2.10 1 0 0 0 1 SRA1
Emphysema/chronic bronchitis 6.12 1 0 0 0 1 SRA1
Mean time to correctly identify matches 2.59 1 0 0 0 1 SRA1
Chest pain or discomfort 2.76 1 0 0 0 1 SRA1
Family relationship satisfaction 12.57 1 0 0 0 1 SRA1
Hypertension (Self-reported) 2.44 1 0 0 0 1 SRA1
Loneliness, isolation 5.85 1 0 0 0 1 SRA1
Medication for cholesterol 2.65 1 0 0 0 1 SRA1
Asthma (self-reported) 4.09 1 0 0 0 1 SRA1
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.54 1 0 0 0 1 SRA1
Miserableness 4.68 1 0 0 0 1 SRA1
Guilty feelings 5.49 1 0 0 0 1 SRA1
Ever taken oral contraceptive pill 5.55 1 0 0 0 1 SRA1
Financial situation satisfaction 5.45 1 0 0 0 1 SRA1
Commuting to job workplace: Public transport 7.54 1 0 0 0 1 SRA1
Medication: Blood pressure 4.73 1 0 0 0 1 SRA1
Irritability 5.83 1 0 0 0 1 SRA1
Ever had prostate specific antigen (PSA) test 3.61 1 0 0 0 1 SRA1
Ever depressed for a whole week 6.97 1 0 0 0 1 SRA1
Impedance of whole body 1.87 1 0 0 0 1 SRA1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.28
GTEx Adipose Visceral Omentum 0 0.0000 1.28
GTEx Adrenal Gland 0 0.0000 1.24
GTEx Artery Aorta 0 0.0000 1.26
GTEx Artery Coronary 0 0.0000 1.24
GTEx Artery Tibial 0 0.0000 1.25
GTEx Brain Caudate basal ganglia 0 0.0000 1.23
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.24
GTEx Brain Cerebellum 0 0.0000 1.26
GTEx Brain Cortex 0 0.0000 1.32
GTEx Brain Frontal Cortex BA9 0 0.0000 1.21
GTEx Brain Hippocampus 0 0.0000 1.32
GTEx Brain Hypothalamus 0 0.0000 1.24
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.27
GTEx Brain Putamen basal ganglia 0 0.0000 1.26
GTEx Breast Mammary Tissue 0 0.0000 1.25
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.22
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.28
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.20
GTEx Cells Transformed fibroblasts 0 0.0000 1.24
GTEx Colon Sigmoid 0 0.0000 1.27
GTEx Colon Transverse 0 0.0000 1.28
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.27
GTEx Esophagus Mucosa 0 0.0000 1.25
GTEx Esophagus Muscularis 0 0.0000 1.26
GTEx Heart Atrial Appendage 0 0.0000 1.26
GTEx Heart Left Ventricle 0 0.0000 1.25
GTEx Liver 0 0.0000 1.36
GTEx Lung 0 0.0000 1.25
GTEx Muscle Skeletal 0 0.0000 1.29
GTEx Nerve Tibial 0 0.0000 1.26
GTEx Ovary 0 0.0000 1.21
GTEx Pancreas 0 0.0000 1.27
GTEx Pituitary 0 0.0000 1.22
GTEx Prostate 0 0.0000 1.30
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.25
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.23
GTEx Small Intestine Terminal Ileum 0 0.0000 1.41
GTEx Spleen 0 0.0000 1.22
GTEx Stomach 0 0.0000 1.27
GTEx Testis 0 0.0000 1.28
GTEx Thyroid 0 0.0000 1.23
GTEx Uterus 0 0.0000 1.19
GTEx Vagina 0 0.0000 1.27
GTEx Whole Blood 0 0.0000 1.30
METSIM Adipose 0 0.0000 1.27
NTR Blood 0 0.0000 1.20
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.28
YFS Blood 0 0.0000 1.25
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.22
TCGA Breast Tumor 0 0.0000 1.12
TCGA Breast Normal 1 0.0238 1.22
TCGA Ovarian Tumor 0 0.0000 1.18
TCGA Prostate Tumor 0 0.0000 1.20