Best TWAS P=2.73e-10 · Best GWAS P=9.1e-21 conditioned to 9.65e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | U91328.19 | 0.21 | 0.25 | lasso | 8 | 0.27 | 3.7e-14 | -5.1 | 5.3 | 9.4e-08 | -0.36 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adrenal Gland | U91328.19 | 0.28 | 0.12 | lasso | 10 | 0.14 | 1.3e-05 | -4.5 | 6.0 | 1.6e-09 | -0.43 | 0.94 | 0.00 | FALSE |
| 3 | GTEx | Artery Aorta | U91328.19 | 0.32 | 0.24 | lasso | 7 | 0.25 | 8.3e-14 | -5.4 | 5.7 | 9.3e-09 | -0.39 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | U91328.19 | 0.26 | 0.32 | lasso | 5 | 0.31 | 1.6e-24 | -5.1 | 5.3 | 1.1e-07 | -0.35 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Caudate basal ganglia | U91328.19 | 0.23 | 0.16 | lasso | 10 | 0.16 | 3.1e-05 | -4.8 | 5.3 | 9.8e-08 | -0.34 | 0.62 | 0.16 | FALSE |
| 6 | GTEx | Brain Cortex | U91328.19 | 0.36 | 0.14 | lasso | 10 | 0.15 | 7.1e-05 | -5.2 | 5.6 | 2.8e-08 | -0.32 | 0.64 | 0.04 | FALSE |
| 7 | GTEx | Brain Frontal Cortex BA9 | U91328.19 | 0.17 | 0.16 | lasso | 4 | 0.18 | 1.8e-05 | -5.2 | 5.4 | 7.7e-08 | -0.32 | 0.44 | 0.07 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | U91328.19 | 0.38 | 0.39 | lasso | 5 | 0.38 | 2.2e-20 | -5.1 | 5.3 | 1.2e-07 | -0.34 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | U91328.19 | 0.39 | 0.27 | lasso | 6 | 0.23 | 1.4e-07 | -5.1 | 5.3 | 1.4e-07 | -0.33 | 0.95 | 0.00 | FALSE |
| 10 | GTEx | Esophagus Gastroesophageal Junction | U91328.19 | 0.28 | 0.07 | lasso | 7 | 0.21 | 4.3e-08 | -5.2 | 5.6 | 2.4e-08 | -0.35 | 0.71 | 0.02 | FALSE |
| 11 | GTEx | Esophagus Mucosa | U91328.19 | 0.45 | 0.42 | lasso | 7 | 0.44 | 6.3e-32 | -5.1 | 5.6 | 1.7e-08 | -0.37 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Esophagus Muscularis | U91328.19 | 0.36 | 0.30 | lasso | 10 | 0.30 | 1.7e-18 | -5.4 | 5.4 | 8.6e-08 | -0.39 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Heart Atrial Appendage | U91328.19 | 0.25 | 0.17 | enet | 6 | 0.13 | 2.0e-06 | -5.1 | 5.3 | 1.1e-07 | -0.35 | 0.99 | 0.00 | FALSE |
| 14 | GTEx | Lung | U91328.19 | 0.20 | 0.22 | enet | 15 | 0.24 | 2.9e-18 | -5.5 | 5.8 | 6.4e-09 | -0.37 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Muscle Skeletal | U91328.19 | 0.28 | 0.26 | enet | 15 | 0.32 | 1.3e-31 | -5.1 | 5.3 | 9.0e-08 | -0.34 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Nerve Tibial | U91328.19 | 0.46 | 0.38 | lasso | 10 | 0.36 | 1.4e-26 | -5.1 | 5.1 | 2.7e-07 | -0.34 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Ovary | U91328.19 | 0.37 | 0.17 | enet | 18 | 0.34 | 4.7e-09 | -5.2 | 6.3 | 2.7e-10 | -0.40 | 0.73 | 0.04 | TRUE |
| 18 | GTEx | Skin Not Sun Exposed Suprapubic | U91328.19 | 0.39 | 0.37 | lasso | 11 | 0.34 | 2.4e-19 | -5.1 | 5.4 | 8.0e-08 | -0.36 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Skin Sun Exposed Lower leg | U91328.19 | 0.29 | 0.34 | lasso | 6 | 0.34 | 5.6e-29 | -5.1 | 5.2 | 1.9e-07 | -0.33 | 1.00 | 0.00 | FALSE |
| 20 | GTEx | Uterus | U91328.19 | 0.38 | 0.05 | enet | 21 | 0.04 | 6.2e-02 | -5.5 | 5.5 | 4.8e-08 | -0.37 | 0.12 | 0.38 | FALSE |
| 21 | METSIM | Adipose | U91328.19 | 0.19 | 0.24 | lasso | 23 | 0.25 | 1.7e-36 | -5.1 | 5.4 | 8.0e-08 | -0.34 | 1.00 | 0.00 | FALSE |