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chr11:118,205,702-119,659,753

Best TWAS P=5.4e-11 · Best GWAS P=5.04e-10 conditioned to 0.434

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	VPS11	0.23	0.22	lasso	3	0.23	2.0e-27	-4.6	-5.4	7.2e-08	-0.81	0.97	0.03	FALSE
2	GTEx	Adipose Subcutaneous	HMBS	0.22	0.14	lasso	3	0.16	1.1e-12	6.1	6.2	6.6e-10	0.97	0.01	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	HMBS	0.14	0.09	lasso	3	0.10	1.2e-05	5.7	5.9	4.1e-09	0.84	0.02	0.97	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-110I1.14	0.14	0.09	lasso	4	0.09	2.5e-05	6.1	-6.1	9.5e-10	-0.93	0.02	0.97	FALSE
5	GTEx	Adrenal Gland	HMBS	0.24	0.17	lasso	5	0.18	7.2e-07	6.1	6.0	1.5e-09	0.98	0.01	0.99	FALSE
6	GTEx	Artery Aorta	HMBS	0.24	0.14	enet	15	0.17	1.6e-09	6.1	6.2	4.8e-10	0.95	0.01	0.99	FALSE
7	GTEx	Artery Aorta	RP11-110I1.14	0.25	0.05	lasso	4	0.13	1.0e-07	6.1	-5.3	1.5e-07	-0.81	0.01	0.98	FALSE
8	GTEx	Artery Coronary	HMBS	0.27	0.19	lasso	4	0.17	2.3e-06	6.1	6.2	6.2e-10	0.97	0.01	0.99	FALSE
9	GTEx	Brain Caudate basal ganglia	VPS11	0.35	0.24	lasso	5	0.21	1.5e-06	6.1	-6.1	9.7e-10	-0.95	0.02	0.98	FALSE
10	GTEx	Brain Cerebellum	HMBS	0.21	0.15	lasso	3	0.15	3.3e-05	6.0	6.1	9.7e-10	0.98	0.01	0.97	FALSE
11	GTEx	Brain Cortex	VPS11	0.40	0.13	enet	16	0.10	9.1e-04	-4.6	-5.7	1.4e-08	-0.86	0.02	0.94	FALSE
12	GTEx	Brain Cortex	HMBS	0.22	0.12	lasso	1	0.11	6.5e-04	6.0	6.0	1.6e-09	0.97	0.02	0.90	FALSE
13	GTEx	Brain Hippocampus	VPS11	0.37	0.13	lasso	4	0.11	1.4e-03	6.0	-6.1	1.2e-09	-0.98	0.02	0.88	FALSE
14	GTEx	Brain Hypothalamus	HMBS	0.22	0.15	enet	12	0.14	4.2e-04	6.1	5.9	3.0e-09	0.85	0.02	0.93	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	VPS11	0.37	0.19	lasso	8	0.30	9.4e-09	6.0	-5.7	1.3e-08	-0.79	0.02	0.95	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	HMBS	0.34	0.14	enet	12	0.20	5.6e-06	6.0	5.5	4.1e-08	0.89	0.02	0.96	FALSE
17	GTEx	Breast Mammary Tissue	HMBS	0.20	0.08	lasso	8	0.08	6.0e-05	6.0	6.0	2.5e-09	0.96	0.02	0.98	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	HMBS	0.26	0.13	lasso	5	0.10	3.8e-04	6.0	6.0	1.5e-09	0.97	0.01	0.98	FALSE
19	GTEx	Cells Transformed fibroblasts	SLC37A4	0.09	0.02	enet	9	0.02	7.5e-03	6.1	5.7	1.1e-08	0.89	0.02	0.95	FALSE
20	GTEx	Cells Transformed fibroblasts	HMBS	0.31	0.25	lasso	7	0.25	1.0e-18	6.1	6.0	1.5e-09	0.95	0.01	0.99	FALSE
21	GTEx	Colon Transverse	HMBS	0.33	0.24	enet	21	0.25	1.9e-12	6.0	5.7	1.0e-08	0.97	0.01	0.99	FALSE
22	GTEx	Esophagus Mucosa	HMBS	0.26	0.18	lasso	5	0.18	3.9e-12	6.1	6.2	6.1e-10	0.97	0.01	0.99	FALSE
23	GTEx	Esophagus Muscularis	HMBS	0.30	0.27	enet	19	0.30	1.2e-18	6.1	5.6	2.2e-08	0.96	0.01	0.99	FALSE
24	GTEx	Heart Atrial Appendage	RP11-110I1.14	0.21	0.01	lasso	9	0.04	5.1e-03	6.0	-5.3	1.0e-07	-0.78	0.02	0.94	FALSE
25	GTEx	Lung	HMBS	0.18	0.14	lasso	3	0.14	1.6e-10	6.1	6.2	7.2e-10	0.97	0.01	0.99	FALSE
26	GTEx	Muscle Skeletal	VPS11	0.35	0.35	lasso	5	0.38	6.4e-40	6.0	5.8	5.4e-09	0.94	0.02	0.98	FALSE
27	GTEx	Muscle Skeletal	HMBS	0.12	0.12	lasso	3	0.12	3.7e-12	6.1	6.2	5.8e-10	0.97	0.01	0.99	FALSE
28	GTEx	Muscle Skeletal	RP11-110I1.14	0.24	0.12	lasso	9	0.15	2.4e-14	6.1	-6.3	4.0e-10	-0.95	0.01	0.99	FALSE
29	GTEx	Nerve Tibial	HMBS	0.10	0.05	lasso	4	0.03	4.6e-03	6.1	5.5	4.4e-08	0.94	0.01	0.99	FALSE
30	GTEx	Pancreas	HMBS	0.25	0.21	enet	10	0.20	6.9e-09	6.1	6.3	3.0e-10	0.94	0.01	0.99	FALSE
31	GTEx	Pancreas	RP11-110I1.14	0.23	0.00	enet	15	0.03	2.5e-02	6.2	-5.1	2.7e-07	-0.91	0.01	0.92	FALSE
32	GTEx	Pituitary	VPS11	0.23	0.16	lasso	3	0.20	9.2e-06	6.2	-5.9	3.1e-09	-0.91	0.02	0.95	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	HMBS	0.24	0.18	lasso	6	0.18	4.5e-10	6.1	6.1	9.5e-10	0.96	0.01	0.99	FALSE
34	GTEx	Skin Sun Exposed Lower leg	HMBS	0.16	0.12	enet	22	0.12	2.1e-10	6.1	5.5	5.0e-08	0.84	0.01	0.99	FALSE
35	GTEx	Small Intestine Terminal Ileum	HMBS	0.49	0.27	enet	17	0.18	9.0e-05	6.2	6.3	4.0e-10	0.98	0.01	0.98	FALSE
36	GTEx	Thyroid	VPS11	0.19	0.12	lasso	6	0.09	1.7e-07	6.1	-6.1	8.9e-10	-0.97	0.01	0.99	FALSE
37	GTEx	Thyroid	HMBS	0.22	0.20	enet	10	0.22	2.2e-16	6.1	6.3	3.6e-10	0.97	0.01	0.99	FALSE
38	GTEx	Thyroid	RP11-110I1.14	0.16	0.13	lasso	3	0.12	9.0e-10	6.1	-6.1	7.9e-10	-0.98	0.01	0.99	FALSE
39	GTEx	Vagina	HMBS	0.23	0.14	lasso	4	0.12	1.1e-03	6.1	6.4	1.5e-10	0.96	0.02	0.88	FALSE
40	METSIM	Adipose	HMBS	0.12	0.07	lasso	8	0.07	3.0e-10	6.1	6.1	1.2e-09	0.97	0.01	0.99	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	VPS11	0.25	0.17	lasso	5	0.18	5.0e-23	6.2	-6.1	1.3e-09	-0.95	0.00	1.00	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	HMBS	0.33	0.22	bslmm	259	0.24	5.1e-30	6.1	5.8	6.6e-09	0.94	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HMBS	0.08	0.03	blup	38	0.04	1.7e-04	6.2	6.5	5.8e-11	0.78	0.00	0.96	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	HMBS	0.11	0.10	enet	4	0.09	1.3e-18	6.1	6.3	4.1e-10	0.96	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HMBS	0.17	0.06	blup	38	0.06	8.7e-04	6.1	5.8	7.2e-09	0.85	0.00	0.94	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	HMBS	0.28	0.14	lasso	2	0.13	8.6e-08	6.1	6.2	7.4e-10	0.97	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HMBS	0.12	0.09	enet	5	0.10	5.2e-11	6.1	5.5	3.6e-08	0.96	0.00	1.00	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HMBS	0.15	0.13	blup	39	0.14	5.7e-16	6.2	6.2	5.3e-10	0.95	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	HMBS	0.13	0.04	lasso	2	0.04	9.0e-06	6.1	6.4	1.6e-10	0.92	0.00	0.99	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS11	0.22	0.18	enet	7	0.21	1.2e-23	6.0	-6.0	1.6e-09	-0.92	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HMBS	0.17	0.08	blup	39	0.08	1.2e-04	6.1	5.3	1.5e-07	0.90	0.00	0.99	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	HMBS	0.25	0.20	lasso	5	0.19	7.3e-22	6.1	6.1	1.3e-09	0.95	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HMBS	0.05	0.03	lasso	8	0.02	2.1e-03	6.1	6.1	1.4e-09	0.95	0.00	0.94	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMBS	0.13	0.07	blup	38	0.07	2.4e-05	6.1	5.9	3.2e-09	0.94	0.00	0.99	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HMBS	0.36	0.16	lasso	3	0.15	5.4e-07	6.1	6.0	1.9e-09	0.91	0.00	1.00	FALSE
56	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HMBS	0.16	0.08	blup	38	0.10	1.1e-04	6.2	5.1	3.0e-07	0.85	0.00	0.97	FALSE
57	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	VPS11	0.24	0.15	lasso	4	0.18	1.4e-07	6.1	-5.9	3.4e-09	-0.89	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	HMBS	0.30	0.18	blup	38	0.18	1.0e-18	6.0	6.6	5.4e-11	0.89	0.00	1.00	TRUE
59	The Cancer Genome Atlas	Rectum Adenocarcinoma	HMBS	0.24	0.08	blup	38	0.04	3.6e-02	6.2	5.5	4.5e-08	0.74	0.00	0.57	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	HMBS	0.13	0.08	lasso	2	0.08	1.5e-06	6.1	6.2	5.6e-10	0.93	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	HMBS	0.17	0.16	lasso	2	0.16	1.1e-15	6.0	6.1	1.1e-09	0.97	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	VPS11	0.31	0.24	lasso	3	0.26	3.8e-25	-4.5	-5.5	3.2e-08	-0.84	0.84	0.16	FALSE