Best TWAS P=1.06e-08 · Best GWAS P=2.78e-09 conditioned to 0.0394
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | SNX19 | 0.21 | 0.15 | enet | 24 | 0.16 | 2.3e-13 | 4.3 | -5.3 | 1.4e-07 | 0.81 | 0.16 | 0.84 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | SNX19 | 0.33 | 0.12 | lasso | 5 | 0.12 | 2.8e-04 | 4.2 | -5.4 | 7.2e-08 | 0.92 | 0.02 | 0.95 | FALSE |
3 | GTEx | Brain Cortex | SNX19 | 0.36 | 0.12 | lasso | 7 | 0.16 | 3.3e-05 | 4.2 | -5.2 | 1.9e-07 | 0.92 | 0.01 | 0.98 | FALSE |
4 | GTEx | Brain Frontal Cortex BA9 | SNX19 | 0.41 | 0.20 | lasso | 7 | 0.37 | 7.1e-11 | -5.6 | -5.4 | 6.6e-08 | 0.84 | 0.02 | 0.98 | FALSE |
5 | GTEx | Brain Hippocampus | SNX19 | 0.24 | 0.07 | enet | 17 | 0.16 | 1.8e-04 | -5.6 | -5.5 | 3.4e-08 | 0.80 | 0.03 | 0.91 | FALSE |
6 | GTEx | Brain Hypothalamus | SNX19 | 0.32 | 0.04 | lasso | 5 | 0.13 | 7.4e-04 | 4.1 | -5.2 | 1.7e-07 | 0.84 | 0.04 | 0.93 | FALSE |
7 | GTEx | Esophagus Muscularis | SNX19 | 0.31 | 0.18 | enet | 23 | 0.25 | 1.2e-15 | 4.3 | -5.7 | 1.1e-08 | 0.85 | 0.02 | 0.98 | TRUE |
8 | GTEx | Heart Atrial Appendage | SNX19 | 0.50 | 0.20 | enet | 32 | 0.32 | 4.9e-15 | -5.2 | -5.2 | 2.4e-07 | 0.72 | 0.03 | 0.97 | FALSE |
9 | GTEx | Heart Left Ventricle | SNX19 | 0.21 | 0.06 | lasso | 4 | 0.05 | 9.7e-04 | 4.2 | -5.2 | 1.8e-07 | 0.91 | 0.02 | 0.97 | FALSE |
10 | GTEx | Pancreas | RP11-890B15.3 | 0.16 | 0.02 | lasso | 2 | 0.01 | 1.9e-01 | -5.9 | -5.5 | 3.9e-08 | 0.95 | 0.01 | 0.96 | FALSE |
11 | GTEx | Stomach | SNX19 | 0.39 | 0.29 | lasso | 13 | 0.27 | 2.0e-13 | 4.2 | -5.1 | 2.6e-07 | 0.86 | 0.21 | 0.79 | FALSE |
12 | GTEx | Testis | SNX19 | 0.59 | 0.25 | enet | 24 | 0.38 | 7.1e-18 | -5.9 | -5.4 | 7.4e-08 | 0.86 | 0.00 | 1.00 | FALSE |