Hub : Traits :

Eye problems/disorders: Cataract

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 20 18506005 20398583 1 1 5.4e-08 6.7e-11 0.00013 66 SLC24A3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body Mass Index (BMI) (2010) 3.59 1 0 0 0 1 SLC24A3
Blood Platelet Count 0.69 1 0 0 0 1 SLC24A3
Blood White Count 1.46 1 0 0 0 1 SLC24A3
Height 0.94 1 0 0 0 1 SLC24A3
Systolic Blood Pressure 5.42 1 1 3 0 1 SLC24A3
Respiratory disease 3.32 1 0 0 0 1 SLC24A3
Lung FEV1/FVC ratio 8.08 1 1 3 0 1 SLC24A3
Sensitivity / hurt feelings 2.54 1 0 0 0 1 SLC24A3
Systolic blood pressure, automated reading 2.83 1 0 0 0 1 SLC24A3
Diabetes (mother) 4.17 1 0 0 0 1 SLC24A3
Pack years adult smoking proportion 3.12 1 0 0 0 1 SLC24A3
Trunk fat percentage 1.35 1 0 0 0 1 SLC24A3
Fed-up feelings 2.29 1 0 0 0 1 SLC24A3
Diverticular disease/diverticulitis (self-reported) 3.82 1 0 0 0 1 SLC24A3
High blood pressure (mother) 4.41 1 0 0 0 1 SLC24A3
Ever unenthusiastic/disinterested for a whole week 3.33 1 0 0 0 1 SLC24A3
Arm fat percentage (right) 1.32 1 0 0 0 1 SLC24A3
Father's age at death 7.83 1 0 0 0 1 SLC24A3
Frequency of tiredness / lethargy in last 2 weeks 2.41 1 0 0 0 1 SLC24A3
Hair/balding pattern: Pattern 3 3.27 1 0 0 0 1 SLC24A3
Asthma 3.18 1 0 0 0 1 SLC24A3
Medication: Ibuprofen (e.g. Nurofen) 9.50 1 0 0 0 1 SLC24A3
Mouth/teeth dental problems: Bleeding gums 3.55 1 0 0 0 1 SLC24A3
Medication: Paracetamol 7.04 1 0 0 0 1 SLC24A3
Headache pain in last month 11.87 1 0 0 0 1 SLC24A3
High blood pressure (siblings) 2.63 1 0 0 0 1 SLC24A3
Body fat percentage 1.35 1 0 0 0 1 SLC24A3
Leg fat percentage (right) 1.13 1 0 0 0 1 SLC24A3
Comparative body size at age 10 1.40 1 0 0 0 1 SLC24A3
Number of full brothers 7.22 1 0 0 0 1 SLC24A3
Eye problems/disorders: None of the above 8.84 1 0 0 0 1 SLC24A3
Medication for pain relief, constipation, heartburn 4.36 1 0 0 0 1 SLC24A3
Migraine (self-reported) 18.40 1 0 0 0 1 SLC24A3
Medication: Ibuprofen 10.81 1 0 0 0 1 SLC24A3
Arm fat percentage (left) 1.51 1 0 0 0 1 SLC24A3
Mood swings 4.25 1 0 0 0 1 SLC24A3
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.81 1 0 0 0 1 SLC24A3
Asthma (self-reported) 3.29 1 0 0 0 1 SLC24A3
Illnesses of father: None of the above (group 1) 3.39 1 0 0 0 1 SLC24A3
Pain type(s) experienced in last month: Hip pain 4.62 1 0 0 0 1 SLC24A3
Medication: Paracetamol 6.65 1 0 0 0 1 SLC24A3
Diastolic blood pressure, automated reading 11.01 1 1 3 0 1 SLC24A3
Medication: Omeprazole (e.g. Zanprol) 4.24 1 0 0 0 1 SLC24A3
Pain experienced in last month 2.61 1 0 0 0 1 SLC24A3
Pack years of smoking 3.03 1 0 0 0 1 SLC24A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.19
GTEx Adipose Visceral Omentum 0 0.0000 1.22
GTEx Adrenal Gland 0 0.0000 1.18
GTEx Artery Aorta 0 0.0000 1.23
GTEx Artery Coronary 0 0.0000 1.23
GTEx Artery Tibial 1 0.0266 1.19
GTEx Brain Caudate basal ganglia 0 0.0000 1.15
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.12
GTEx Brain Cerebellum 0 0.0000 1.17
GTEx Brain Cortex 0 0.0000 1.19
GTEx Brain Frontal Cortex BA9 0 0.0000 1.20
GTEx Brain Hippocampus 0 0.0000 1.14
GTEx Brain Hypothalamus 0 0.0000 1.18
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.23
GTEx Brain Putamen basal ganglia 0 0.0000 1.16
GTEx Breast Mammary Tissue 0 0.0000 1.18
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.19
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.17
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.20
GTEx Cells Transformed fibroblasts 0 0.0000 1.19
GTEx Colon Sigmoid 0 0.0000 1.17
GTEx Colon Transverse 0 0.0000 1.19
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.20
GTEx Esophagus Mucosa 0 0.0000 1.21
GTEx Esophagus Muscularis 0 0.0000 1.16
GTEx Heart Atrial Appendage 0 0.0000 1.17
GTEx Heart Left Ventricle 0 0.0000 1.29
GTEx Liver 0 0.0000 1.19
GTEx Lung 0 0.0000 1.19
GTEx Muscle Skeletal 0 0.0000 1.15
GTEx Nerve Tibial 0 0.0000 1.17
GTEx Ovary 0 0.0000 1.31
GTEx Pancreas 0 0.0000 1.12
GTEx Pituitary 0 0.0000 1.26
GTEx Prostate 0 0.0000 1.31
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.21
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.17
GTEx Small Intestine Terminal Ileum 0 0.0000 1.24
GTEx Spleen 0 0.0000 1.22
GTEx Stomach 0 0.0000 1.21
GTEx Testis 0 0.0000 1.13
GTEx Thyroid 0 0.0000 1.14
GTEx Uterus 0 0.0000 1.21
GTEx Vagina 0 0.0000 1.26
GTEx Whole Blood 0 0.0000 1.22
METSIM Adipose 0 0.0000 1.13
NTR Blood 0 0.0000 1.19
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.17
YFS Blood 0 0.0000 1.15
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.11
TCGA Breast Tumor 0 0.0000 1.04
TCGA Breast Normal 0 0.0000 1.15
TCGA Ovarian Tumor 0 0.0000 1.10
TCGA Prostate Tumor 0 0.0000 1.14