Best TWAS P=1.14e-11 · Best GWAS P=1.41e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-378J18.8 | 0.12 | 0.11 | enet | 33 | 0.12 | 4.3e-10 | -6.8 | -5.4 | 6.0e-08 | 0.79 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Aorta | RP11-378J18.8 | 0.12 | 0.15 | lasso | 7 | 0.14 | 3.2e-08 | -6.7 | -6.7 | 2.0e-11 | 0.99 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-378J18.8 | 0.06 | 0.03 | enet | 14 | 0.04 | 4.1e-04 | -6.7 | -5.6 | 1.9e-08 | 0.84 | 0.01 | 0.97 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | AIDA | 0.17 | 0.13 | lasso | 3 | 0.14 | 1.7e-04 | -5.2 | 5.9 | 2.9e-09 | -0.84 | 0.03 | 0.83 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | RP11-378J18.8 | 0.22 | 0.14 | lasso | 6 | 0.17 | 4.5e-05 | -3.3 | -5.4 | 5.3e-08 | 0.76 | 0.01 | 0.96 | FALSE |
| 6 | GTEx | Brain Cerebellum | RP11-378J18.8 | 0.24 | 0.20 | lasso | 7 | 0.18 | 4.1e-06 | -6.7 | -6.6 | 3.0e-11 | 1.00 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Brain Hypothalamus | RP11-378J18.8 | 0.28 | 0.17 | lasso | 6 | 0.07 | 8.9e-03 | -5.7 | -5.6 | 1.6e-08 | 0.82 | 0.03 | 0.72 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | RP11-378J18.8 | 0.14 | 0.11 | lasso | 3 | 0.07 | 1.7e-04 | -6.8 | -6.7 | 1.5e-11 | 1.00 | 0.00 | 0.99 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | RP11-378J18.8 | 0.21 | 0.15 | lasso | 5 | 0.11 | 3.8e-04 | -6.8 | -6.8 | 1.3e-11 | 0.99 | 0.01 | 0.97 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | MIA3 | 0.12 | 0.00 | enet | 16 | 0.07 | 6.4e-06 | -6.7 | -5.3 | 1.5e-07 | 0.67 | 0.01 | 0.97 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | RP11-378J18.8 | 0.09 | 0.02 | enet | 9 | 0.02 | 5.6e-03 | -6.7 | -6.4 | 2.0e-10 | 0.97 | 0.01 | 0.97 | FALSE |
| 12 | GTEx | Colon Sigmoid | RP11-378J18.8 | 0.29 | 0.09 | lasso | 5 | 0.10 | 2.7e-04 | -5.9 | -5.5 | 4.1e-08 | 0.84 | 0.01 | 0.96 | FALSE |
| 13 | GTEx | Esophagus Gastroesophageal Junction | RP11-378J18.8 | 0.19 | 0.05 | lasso | 9 | 0.05 | 6.4e-03 | -5.9 | -6.2 | 4.3e-10 | 0.90 | 0.01 | 0.98 | FALSE |
| 14 | GTEx | Esophagus Muscularis | AIDA | 0.14 | 0.02 | enet | 22 | 0.06 | 1.2e-04 | -5.2 | 5.7 | 9.0e-09 | -0.73 | 0.02 | 0.96 | FALSE |
| 15 | GTEx | Esophagus Muscularis | RP11-378J18.8 | 0.19 | 0.13 | lasso | 5 | 0.14 | 4.7e-09 | -6.8 | -6.2 | 4.6e-10 | 0.89 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Lung | RP11-378J18.8 | 0.05 | 0.05 | lasso | 1 | 0.02 | 1.2e-02 | -6.7 | -6.7 | 2.6e-11 | 1.00 | 0.00 | 0.99 | FALSE |
| 17 | GTEx | Nerve Tibial | MIA3 | 0.08 | 0.00 | lasso | 4 | 0.01 | 6.6e-02 | -6.8 | -6.4 | 1.1e-10 | 0.96 | 0.01 | 0.96 | FALSE |
| 18 | GTEx | Nerve Tibial | RP11-378J18.8 | 0.13 | 0.13 | lasso | 7 | 0.11 | 3.0e-08 | -6.7 | -6.8 | 1.1e-11 | 0.99 | 0.00 | 1.00 | TRUE |
| 19 | GTEx | Ovary | RP11-378J18.8 | 0.28 | 0.21 | lasso | 7 | 0.12 | 5.8e-04 | -6.8 | -6.7 | 2.8e-11 | 0.97 | 0.01 | 0.96 | FALSE |
| 20 | GTEx | Prostate | AIDA | 0.26 | 0.06 | lasso | 6 | 0.06 | 1.7e-02 | -5.2 | 5.2 | 2.0e-07 | -0.65 | 0.05 | 0.11 | FALSE |
| 21 | GTEx | Skin Sun Exposed Lower leg | RP11-378J18.8 | 0.10 | 0.08 | lasso | 4 | 0.07 | 8.8e-07 | -6.8 | -6.5 | 8.5e-11 | 0.93 | 0.00 | 1.00 | FALSE |
| 22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AIDA | 0.02 | 0.01 | enet | 5 | 0.01 | 3.4e-02 | -5.6 | 6.5 | 6.2e-11 | -0.92 | 0.01 | 0.95 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AIDA | 0.02 | 0.01 | blup | 53 | 0.02 | 5.0e-03 | -5.9 | 5.7 | 1.0e-08 | -0.84 | 0.01 | 0.80 | FALSE |
| 24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MIA3 | 0.05 | 0.00 | blup | 53 | 0.01 | 7.3e-03 | -5.2 | -5.5 | 3.2e-08 | 0.75 | 0.02 | 0.73 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | AIDA | 0.06 | 0.02 | lasso | 3 | 0.01 | 2.5e-02 | -6.7 | 6.6 | 3.0e-11 | -0.99 | 0.00 | 0.97 | FALSE |