Hub : Traits :

Neck or shoulder pain in last month

3 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 57622089 59105913 1 1 1.5e-07 1.5e-07 1.00 100 PXK
2 16 71206836 72569466 1 1 2.0e-08 2.4e-06 0.65 99 ATXN1L

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Verbal and Numeric Reasoning (VNR) 5.32 1 1 3 0 1 ATXN1L
Breast Cancer 3.59 1 0 0 0 1 ATXN1L
Ovarian Cancer 4.77 1 0 0 0 1 ATXN1L
Age at First Birth 2.31 1 0 0 0 1 ATXN1L
Mean Putamen Volume 7.93 1 0 0 0 1 PXK
HDL Cholesterol 2.22 1 0 0 0 1 ATXN1L
LDL Cholesterol 4.75 2 0 0 0 1 ATXN1L PXK
Lupus 6.94 1 0 0 0 1 PXK
Blood Platelet Count 1.62 2 0 0 0 1 ATXN1L PXK
Blood Red Count 3.14 2 1 3 0 1 ATXN1L PXK
BMI 1.21 1 0 0 0 1 ATXN1L
Height 1.25 1 1 3 0 1 ATXN1L
Systolic Blood Pressure 4.61 1 1 3 0 1 ATXN1L
Cardiovascular Disease 3.05 1 0 0 0 1 ATXN1L
Hypothyroidism (self reported) 2.64 1 0 0 0 1 PXK
Lung FEV1/FVC ratio 1.49 1 0 0 0 1 PXK
Neuroticism 2.60 1 0 0 0 1 ATXN1L
Hair Pigment 0.23 1 0 0 0 1 ATXN1L
Tanning 0.68 1 0 0 0 1 ATXN1L
Hand grip strength (left) 2.21 1 0 0 0 1 ATXN1L
Hearing difficulty/problems: Yes 5.20 1 0 0 0 1 ATXN1L
Systolic blood pressure, automated reading 2.42 1 0 0 0 1 ATXN1L
Leg fat-free mass (left) 1.70 1 0 0 0 1 ATXN1L
Hand grip strength (right) 1.85 1 0 0 0 1 ATXN1L
Fed-up feelings 3.93 1 0 0 0 1 ATXN1L
Frequency of unenthusiasm / disinterest in last 2 weeks 4.78 1 0 0 0 1 ATXN1L
Age when periods started (menarche) 2.11 1 0 0 0 1 PXK
Bilateral oophorectomy (both ovaries removed) 5.28 1 0 0 0 1 ATXN1L
High blood pressure 1.94 1 0 0 0 1 ATXN1L
Stomach or abdominal pain in last month 7.00 2 0 0 0 1 ATXN1L PXK
Diverticular disease/diverticulitis (self-reported) 3.55 1 0 0 0 1 PXK
Medication: Levothyroxine sodium 3.87 1 0 0 0 1 PXK
Sitting height 1.11 1 0 0 0 1 ATXN1L
Body mass index (BMI) 1.17 1 0 0 0 1 ATXN1L
Leg predicted mass (left) 1.68 1 0 0 0 1 ATXN1L
Trunk fat mass 1.45 1 0 0 0 1 ATXN1L
Waist circumference 1.39 1 0 0 0 1 ATXN1L
Nervous feelings 1.94 1 0 0 0 1 ATXN1L
Hearing difficulty/problems with background noise 3.93 1 0 0 0 1 ATXN1L
Forced vital capacity (FVC) 1.46 1 0 0 0 1 ATXN1L
Qualifications: None of the above 5.05 1 0 0 0 1 ATXN1L
Medication: Simvastatin 2.87 1 0 0 0 1 ATXN1L
Fluid intelligence score 6.39 1 0 0 0 1 ATXN1L
Neuroticism score 1.83 1 0 0 0 1 ATXN1L
Weight 2.08 1 0 0 0 1 ATXN1L
Impedance of arm (right) 1.62 1 0 0 0 1 ATXN1L
Trunk fat-free mass 2.58 1 1 3 0 1 ATXN1L
Frequency of tiredness / lethargy in last 2 weeks 3.44 1 0 0 0 1 ATXN1L
Number of live births 4.41 1 0 0 0 1 ATXN1L
Forced expiratory volume in 1-second (FEV1) 2.26 1 0 0 0 1 ATXN1L
Pulse rate 3.05 1 0 0 0 1 PXK
Qualifications: A levels/AS levels or equivalent 3.60 2 0 0 0 1 ATXN1L PXK
Medication: Cholesterol lowering 4.87 1 0 0 0 1 ATXN1L
Prospective memory result 3.51 1 0 0 0 1 ATXN1L
Forced expiratory volume in 1-second (FEV1), Best measure 2.31 1 0 0 0 1 ATXN1L
Impedance of arm (left) 1.19 1 0 0 0 1 ATXN1L
Arm fat mass (right) 1.45 1 0 0 0 1 ATXN1L
Trunk predicted mass 2.66 1 1 3 0 1 ATXN1L
Standing height 1.14 1 0 0 0 1 ATXN1L
Ever highly irritable/argumentative for 2 days 3.42 1 0 0 0 1 ATXN1L
Loud music exposure frequency 4.52 1 0 0 0 1 ATXN1L
Qualifications: O levels/GCSEs or equivalent 4.72 1 0 0 0 1 ATXN1L
Medication for cholesterol, blood pressure or diabetes 2.26 1 0 0 0 1 ATXN1L
Hypothyroidism/myxoedema (self-reported) 4.01 1 0 0 0 1 PXK
Forced vital capacity (FVC), Best measure 2.19 1 0 0 0 1 ATXN1L
Arm fat-free mass (right) 3.38 1 1 3 0 1 ATXN1L
Wheeze or whistling in the chest in last year 1.94 1 0 0 0 1 PXK
Age at first live birth 5.18 2 0 0 0 1 ATXN1L PXK
Health satisfaction 2.96 1 0 0 0 1 ATXN1L
Shortness of breath walking on level ground 3.30 1 0 0 0 1 ATXN1L
Qualifications: College or University degree 4.72 2 0 0 0 1 ATXN1L PXK
Eye problems/disorders: None of the above 4.50 1 0 0 0 1 PXK
Emphysema/chronic bronchitis 6.16 1 0 0 0 1 PXK
Whole body fat mass 1.45 1 0 0 0 1 ATXN1L
Leg fat mass (right) 1.31 1 0 0 0 1 ATXN1L
Arm predicted mass (right) 3.22 1 1 3 0 1 ATXN1L
Pulse rate, automated reading 3.19 2 0 0 0 1 ATXN1L PXK
Alcohol intake frequency. 2.50 1 0 0 0 1 PXK
Comparative height size at age 10 2.88 1 1 3 0 1 ATXN1L
Overall health rating 8.84 2 1 3 0 1 ATXN1L PXK
Age at last live birth 3.74 1 0 0 0 1 PXK
Commuting to job workplace: Car/motor vehicle 4.70 1 0 0 0 1 ATXN1L
Knee pain experienced in last month 3.06 1 0 0 0 1 ATXN1L
Hypertension (Self-reported) 1.60 1 0 0 0 1 ATXN1L
Whole body fat-free mass 2.36 1 1 3 0 1 ATXN1L
Leg fat-free mass (right) 1.72 1 0 0 0 1 ATXN1L
Mood swings 1.75 1 0 0 0 1 ATXN1L
Qualifications: nursing, teaching 3.17 1 0 0 0 1 ATXN1L
Commuting to job workplace: Walk 3.29 1 0 0 0 1 ATXN1L
Back pain experienced in last month 5.68 1 0 0 0 1 ATXN1L
Mineral and other dietary supplements 3.48 1 0 0 0 1 PXK
Breast cancer (self-reported) 2.86 1 0 0 0 1 ATXN1L
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.89 1 0 0 0 1 ATXN1L
Whole body water mass 2.38 1 1 3 0 1 ATXN1L
Leg predicted mass (right) 1.73 1 0 0 0 1 ATXN1L
Arm fat mass (left) 1.55 1 0 0 0 1 ATXN1L
Average weekly champagne plus white wine intake 2.62 1 0 0 0 1 PXK
Commuting to job workplace: Public transport 4.24 1 0 0 0 1 ATXN1L
Medication: Blood pressure 2.14 1 0 0 0 1 ATXN1L
Supplements: Fish oil (including cod liver oil) 2.94 1 0 0 0 1 PXK
High cholesterol (Self-reported) 3.75 1 0 0 0 1 ATXN1L
Medication: Atorvastatin 4.57 1 0 0 0 1 ATXN1L
Basal metabolic rate 2.36 1 1 3 0 1 ATXN1L
Arm fat-free mass (left) 3.15 1 1 3 0 1 ATXN1L
Irritability 2.23 1 0 0 0 1 ATXN1L
Diastolic blood pressure, automated reading 1.48 1 0 0 0 1 ATXN1L
Vascular/heart problems diagnosed by doctor 2.07 1 0 0 0 1 ATXN1L
Pain experienced in last month 10.69 1 1 3 0 1 ATXN1L
Leg fat mass (left) 1.57 1 0 0 0 1 ATXN1L
Arm predicted mass (left) 2.97 1 1 3 0 1 ATXN1L

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.46
GTEx Adipose Visceral Omentum 1 0.0491 1.50
GTEx Adrenal Gland 0 0.0000 1.41
GTEx Artery Aorta 0 0.0000 1.45
GTEx Artery Coronary 0 0.0000 1.45
GTEx Artery Tibial 0 0.0000 1.43
GTEx Brain Caudate basal ganglia 0 0.0000 1.49
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.49
GTEx Brain Cerebellum 0 0.0000 1.41
GTEx Brain Cortex 0 0.0000 1.45
GTEx Brain Frontal Cortex BA9 0 0.0000 1.48
GTEx Brain Hippocampus 0 0.0000 1.42
GTEx Brain Hypothalamus 0 0.0000 1.41
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.34
GTEx Brain Putamen basal ganglia 0 0.0000 1.30
GTEx Breast Mammary Tissue 0 0.0000 1.49
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.34
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.43
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.50
GTEx Cells Transformed fibroblasts 0 0.0000 1.46
GTEx Colon Sigmoid 0 0.0000 1.45
GTEx Colon Transverse 0 0.0000 1.51
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.44
GTEx Esophagus Mucosa 0 0.0000 1.49
GTEx Esophagus Muscularis 0 0.0000 1.48
GTEx Heart Atrial Appendage 0 0.0000 1.41
GTEx Heart Left Ventricle 0 0.0000 1.51
GTEx Liver 0 0.0000 1.59
GTEx Lung 0 0.0000 1.48
GTEx Muscle Skeletal 0 0.0000 1.50
GTEx Nerve Tibial 0 0.0000 1.42
GTEx Ovary 0 0.0000 1.52
GTEx Pancreas 0 0.0000 1.38
GTEx Pituitary 0 0.0000 1.48
GTEx Prostate 0 0.0000 1.45
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.49
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.46
GTEx Small Intestine Terminal Ileum 0 0.0000 1.54
GTEx Spleen 0 0.0000 1.52
GTEx Stomach 0 0.0000 1.52
GTEx Testis 0 0.0000 1.40
GTEx Thyroid 0 0.0000 1.47
GTEx Uterus 0 0.0000 1.48
GTEx Vagina 0 0.0000 1.27
GTEx Whole Blood 0 0.0000 1.45
METSIM Adipose 0 0.0000 1.37
NTR Blood 0 0.0000 1.37
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.46
YFS Blood 1 0.0217 1.39
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.38
TCGA Breast Tumor 0 0.0000 1.54
TCGA Breast Normal 0 0.0000 1.35
TCGA Ovarian Tumor 0 0.0000 1.26
TCGA Prostate Tumor 0 0.0000 1.38