Hub : Traits :

Pain type(s) experienced in last month: Hip pain

3 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 149194858 150734256 2 1 3.7e-07 5.8e-07 1.0000 100 GINM1
2 8 120367602 121763223 1 1 3.3e-07 1.0e-05 0.0026 53 RP11-760H22.2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 3.93 1 0 0 0 1 RP11-760H22.2
Reaction Time 3.50 1 0 0 0 1 RP11-760H22.2
Breast Cancer 1.40 1 0 0 0 1 RP11-760H22.2
Schizophrenia 1.53 1 0 0 0 1 GINM1
Blood Platelet Count 0.44 1 0 0 0 1 RP11-760H22.2
Blood Red Count 1.41 2 0 0 0 1 GINM1 RP11-760H22.2
Blood White Count 0.69 1 0 0 0 1 RP11-760H22.2
Heel T-Score 0.50 1 0 0 0 1 GINM1
BMI 0.61 1 0 0 0 1 RP11-760H22.2
Height 1.44 1 1 3 0 1 RP11-760H22.2
Allergy or Eczema 2.16 1 0 0 0 1 GINM1
Lung FEV1/FVC ratio 1.05 1 0 0 0 1 RP11-760H22.2
Lung FVC 1.34 1 0 0 0 1 GINM1
Hand grip strength (left) 4.60 1 0 0 0 1 GINM1
Sensitivity / hurt feelings 3.35 1 0 0 0 1 GINM1
Relative age of first facial hair 1.56 1 0 0 0 1 GINM1
Eye problems/disorders: Diabetes related eye disease 2.79 1 0 0 0 1 RP11-760H22.2
Medication: Metformin 2.80 1 0 0 0 1 RP11-760H22.2
Hand grip strength (right) 5.09 2 0 0 0 1 GINM1 RP11-760H22.2
Townsend deprivation index at recruitment 2.96 1 0 0 0 1 GINM1
Hayfever, allergic rhinitis or eczema 1.99 1 0 0 0 1 GINM1
Sitting height 1.57 2 0 0 0 1 GINM1 RP11-760H22.2
Impedance of leg (left) 0.65 1 0 0 0 1 GINM1
Alcohol usually taken with meals 3.41 1 0 0 0 1 RP11-760H22.2
Hearing difficulty/problems with background noise 2.05 1 0 0 0 1 GINM1
Forced vital capacity (FVC) 1.80 1 0 0 0 1 RP11-760H22.2
Mouth/teeth dental problems 2.39 1 0 0 0 1 GINM1
Impedance of arm (right) 0.76 1 0 0 0 1 GINM1
Trunk fat-free mass 0.88 1 0 0 0 1 RP11-760H22.2
Number of live births 6.67 1 0 0 0 1 GINM1
Happiness 2.88 1 0 0 0 1 GINM1
Forced expiratory volume in 1-second (FEV1), Best measure 2.18 1 0 0 0 1 RP11-760H22.2
Impedance of arm (left) 0.94 1 0 0 0 1 GINM1
Trunk predicted mass 0.86 1 0 0 0 1 RP11-760H22.2
Standing height 1.57 1 1 3 0 1 RP11-760H22.2
Breastfed as a baby 5.43 1 0 0 0 1 GINM1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.22 1 0 0 0 1 GINM1
Peak expiratory flow (PEF) 2.41 1 0 0 0 1 GINM1
Gout (self-reported) 2.41 1 0 0 0 1 GINM1
Forced vital capacity (FVC), Best measure 2.59 2 0 0 0 1 GINM1 RP11-760H22.2
Leg fat percentage (right) 1.25 1 0 0 0 1 RP11-760H22.2
Arm fat-free mass (right) 0.93 1 0 0 0 1 RP11-760H22.2
Number of full brothers 5.76 1 0 0 0 1 GINM1
Age at first live birth 2.26 1 0 0 0 1 GINM1
Mouth/teeth dental problems: Loose teeth 3.23 1 0 0 0 1 GINM1
Medication: Allopurinol 3.08 1 0 0 0 1 GINM1
Mean time to correctly identify matches 3.10 1 0 0 0 1 RP11-760H22.2
Comparative height size at age 10 0.96 1 0 0 0 1 RP11-760H22.2
Chest pain or discomfort 4.10 1 0 0 0 1 GINM1
Knee pain experienced in last month 4.78 1 0 0 0 1 GINM1
Illnesses of siblings: Diabetes 3.71 1 0 0 0 1 GINM1
Forced expiratory volume in 1-second (FEV1), predicted 1.79 1 0 0 0 1 RP11-760H22.2
Whole body fat-free mass 0.77 1 0 0 0 1 RP11-760H22.2
Leg fat-free mass (right) 0.78 1 0 0 0 1 RP11-760H22.2
Diabetes diagnosed by doctor 1.96 1 0 0 0 1 RP11-760H22.2
Back pain experienced in last month 4.99 2 0 0 0 1 GINM1 RP11-760H22.2
Medication: Aspirin 3.05 1 0 0 0 1 RP11-760H22.2
Medication: Gliclazide 3.93 1 0 0 0 1 RP11-760H22.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.21 1 0 0 0 1 GINM1
Whole body water mass 0.78 1 0 0 0 1 RP11-760H22.2
Leg predicted mass (right) 0.79 1 0 0 0 1 RP11-760H22.2
Average weekly champagne plus white wine intake 2.47 1 0 0 0 1 GINM1
Leg fat percentage (left) 0.96 1 0 0 0 1 RP11-760H22.2
Average weekly beer plus cider intake 3.44 1 0 0 0 1 GINM1
Pain experienced in last month 4.57 1 0 0 0 1 GINM1
Impedance of whole body 1.00 1 0 0 0 1 GINM1
Arm predicted mass (left) 0.95 1 0 0 0 1 RP11-760H22.2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.30
GTEx Adipose Visceral Omentum 0 0.0000 1.25
GTEx Adrenal Gland 0 0.0000 1.27
GTEx Artery Aorta 0 0.0000 1.31
GTEx Artery Coronary 0 0.0000 1.31
GTEx Artery Tibial 0 0.0000 1.29
GTEx Brain Caudate basal ganglia 0 0.0000 1.27
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.36
GTEx Brain Cerebellum 1 0.0505 1.35
GTEx Brain Cortex 0 0.0000 1.37
GTEx Brain Frontal Cortex BA9 0 0.0000 1.40
GTEx Brain Hippocampus 0 0.0000 1.28
GTEx Brain Hypothalamus 0 0.0000 1.34
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.26
GTEx Brain Putamen basal ganglia 0 0.0000 1.38
GTEx Breast Mammary Tissue 0 0.0000 1.28
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.26
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.22
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.30
GTEx Cells Transformed fibroblasts 0 0.0000 1.27
GTEx Colon Sigmoid 1 0.0684 1.37
GTEx Colon Transverse 0 0.0000 1.30
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.34
GTEx Esophagus Mucosa 0 0.0000 1.29
GTEx Esophagus Muscularis 0 0.0000 1.30
GTEx Heart Atrial Appendage 0 0.0000 1.32
GTEx Heart Left Ventricle 0 0.0000 1.24
GTEx Liver 0 0.0000 1.24
GTEx Lung 0 0.0000 1.26
GTEx Muscle Skeletal 0 0.0000 1.34
GTEx Nerve Tibial 0 0.0000 1.26
GTEx Ovary 0 0.0000 1.33
GTEx Pancreas 0 0.0000 1.26
GTEx Pituitary 0 0.0000 1.33
GTEx Prostate 0 0.0000 1.30
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.24
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.34
GTEx Small Intestine Terminal Ileum 0 0.0000 1.35
GTEx Spleen 0 0.0000 1.28
GTEx Stomach 0 0.0000 1.22
GTEx Testis 0 0.0000 1.29
GTEx Thyroid 0 0.0000 1.28
GTEx Uterus 0 0.0000 1.36
GTEx Vagina 0 0.0000 1.28
GTEx Whole Blood 0 0.0000 1.28
METSIM Adipose 0 0.0000 1.26
NTR Blood 0 0.0000 1.27
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.25
YFS Blood 0 0.0000 1.20
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.29
TCGA Breast Tumor 0 0.0000 1.22
TCGA Breast Normal 0 0.0000 1.15
TCGA Ovarian Tumor 0 0.0000 1.26
TCGA Prostate Tumor 0 0.0000 1.25