Best TWAS P=6.84e-09 · Best GWAS P=1.72e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ZDHHC4 | 0.29 | 0.09 | enet | 19 | 0.13 | 7.5e-08 | 3.0 | -5.3 | 8.9e-08 | -0.05 | 0.86 | 0.02 | TRUE |
| 2 | GTEx | Esophagus Mucosa | FBXL18 | 0.16 | 0.12 | lasso | 2 | 0.11 | 8.2e-08 | 5.6 | 5.6 | 1.7e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Esophagus Mucosa | AC092171.4 | 0.14 | 0.07 | lasso | 3 | 0.05 | 3.2e-04 | 5.6 | 5.8 | 6.8e-09 | 1.00 | 0.00 | 1.00 | TRUE |
| 4 | METSIM | Adipose | FBXL18 | 0.08 | 0.06 | lasso | 3 | 0.05 | 1.6e-07 | 5.6 | 5.8 | 7.8e-09 | 0.99 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAC1 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.8e-05 | 4.1 | 5.3 | 1.0e-07 | -0.06 | 0.04 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAC1 | 0.08 | 0.02 | blup | 63 | 0.06 | 7.0e-07 | 3.5 | 5.6 | 2.7e-08 | -0.05 | 0.28 | 0.69 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | DAGLB | 0.06 | 0.02 | blup | 71 | 0.03 | 7.4e-04 | 4.7 | -5.5 | 4.6e-08 | 0.10 | 0.03 | 0.43 | FALSE |