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chr13:114,302,502-115,106,996

Best TWAS P=2.08e-09 · Best GWAS P=2.76e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CDC16	0.17	0.17	lasso	4	0.19	3.6e-15	5.5	5.6	2.5e-08	1.00	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	CDC16	0.12	0.11	lasso	4	0.09	1.5e-05	5.8	5.6	2.6e-08	0.98	0.02	0.98	FALSE
3	GTEx	Artery Aorta	CDC16	0.15	0.18	enet	10	0.17	1.6e-09	5.9	5.3	1.1e-07	0.98	0.01	0.99	FALSE
4	GTEx	Artery Tibial	CDC16	0.23	0.26	lasso	8	0.25	2.8e-19	5.6	5.8	7.0e-09	1.00	0.01	0.99	FALSE
5	GTEx	Brain Cerebellar Hemisphere	CDC16	0.17	0.10	lasso	9	0.17	3.5e-05	5.5	5.4	5.7e-08	0.92	0.02	0.97	FALSE
6	GTEx	Brain Cerebellum	CDC16	0.18	0.05	lasso	4	0.07	3.4e-03	5.9	5.4	6.2e-08	0.96	0.01	0.97	FALSE
7	GTEx	Breast Mammary Tissue	CDC16	0.25	0.28	lasso	6	0.26	6.9e-14	5.8	5.3	1.5e-07	0.96	0.02	0.98	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	CDC16	0.14	0.09	lasso	3	0.10	2.9e-04	5.9	5.9	3.0e-09	0.99	0.01	0.98	FALSE
9	GTEx	Cells Transformed fibroblasts	CDC16	0.17	0.13	lasso	6	0.15	4.6e-11	5.9	6.0	2.3e-09	0.99	0.01	0.99	FALSE
10	GTEx	Colon Sigmoid	UPF3A	0.15	0.10	lasso	8	0.08	8.3e-04	5.9	6.0	2.1e-09	0.98	0.01	0.98	TRUE
11	GTEx	Colon Transverse	CDC16	0.18	0.23	lasso	5	0.21	3.2e-10	5.8	5.4	6.4e-08	0.98	0.01	0.99	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	CDC16	0.09	0.05	lasso	2	0.02	5.7e-02	5.8	5.6	1.7e-08	0.99	0.02	0.90	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	UPF3A	0.20	0.07	lasso	6	0.06	4.5e-03	5.9	5.7	1.4e-08	0.99	0.01	0.96	FALSE
14	GTEx	Esophagus Mucosa	CDC16	0.35	0.46	lasso	6	0.46	1.0e-33	5.8	5.8	5.4e-09	1.00	0.01	0.99	FALSE
15	GTEx	Lung	CDC16	0.16	0.21	lasso	5	0.19	9.6e-15	5.5	5.5	3.7e-08	0.99	0.02	0.98	FALSE
16	GTEx	Muscle Skeletal	CDC16	0.05	0.06	lasso	1	0.05	9.2e-06	5.6	5.6	2.1e-08	1.00	0.02	0.98	FALSE
17	GTEx	Pancreas	CDC16	0.09	0.14	lasso	3	0.06	1.8e-03	5.8	5.8	5.9e-09	0.99	0.02	0.96	FALSE
18	GTEx	Prostate	CDC16	0.17	0.16	lasso	3	0.11	1.4e-03	5.8	5.8	5.5e-09	1.00	0.02	0.94	FALSE
19	GTEx	Skin Sun Exposed Lower leg	CDC16	0.31	0.33	lasso	7	0.33	4.1e-28	5.9	5.6	2.1e-08	0.98	0.01	0.99	FALSE
20	GTEx	Spleen	CDC16	0.25	0.19	lasso	7	0.21	4.9e-06	5.9	5.2	1.7e-07	0.98	0.01	0.98	FALSE
21	GTEx	Testis	CDC16	0.32	0.30	enet	26	0.35	4.4e-16	5.8	5.5	4.6e-08	0.94	0.01	0.99	FALSE
22	GTEx	Thyroid	CDC16	0.12	0.13	lasso	2	0.11	8.2e-09	5.9	5.9	3.3e-09	1.00	0.01	0.99	FALSE
23	GTEx	Whole Blood	CDC16	0.31	0.20	lasso	5	0.20	4.4e-18	5.9	5.9	3.3e-09	0.98	0.01	0.99	FALSE
24	METSIM	Adipose	CDC16	0.18	0.27	enet	18	0.26	6.6e-39	5.8	5.1	2.9e-07	0.96	0.02	0.98	FALSE
25	NTR	Blood	CDC16	0.10	0.20	bslmm	209	0.20	3.1e-63	5.9	5.9	4.2e-09	1.00	0.01	0.99	FALSE
26	YFS	Blood	CDC16	0.28	0.54	enet	30	0.55	1.1e-220	5.9	5.4	5.2e-08	0.99	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CDC16	0.08	0.11	lasso	5	0.12	4.3e-10	5.8	5.8	6.1e-09	0.99	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDC16	0.01	0.01	blup	49	0.01	1.1e-03	5.6	5.5	3.1e-08	0.97	0.01	0.96	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CDC16	0.05	0.08	lasso	4	0.08	7.2e-09	5.9	6.0	2.2e-09	0.99	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDC16	0.05	0.04	blup	49	0.05	2.0e-06	5.5	5.2	2.2e-07	0.95	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDC16	0.04	0.01	blup	49	0.03	7.7e-03	5.8	5.3	9.9e-08	0.96	0.01	0.95	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CDC16	0.03	0.04	lasso	3	0.04	1.3e-05	4.8	5.6	1.9e-08	0.90	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CDC16	0.11	0.09	blup	49	0.09	1.8e-04	5.5	6.0	2.1e-09	0.98	0.01	0.97	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CDC16	0.07	0.03	blup	49	0.05	6.3e-03	5.8	5.3	9.3e-08	0.94	0.01	0.85	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	CDC16	0.06	0.09	lasso	3	0.09	3.3e-09	5.8	5.7	1.4e-08	0.98	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	UPF3A	0.14	0.11	enet	9	0.15	1.7e-14	4.8	5.3	9.7e-08	0.78	0.05	0.95	FALSE