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Cardiovascular Disease
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chr3:53,164,803-54,579,051
Best TWAS P=7.56e-10 · Best GWAS P=9.31e-13 conditioned to 3.83e-05
53.2M
53.4M
53.6M
53.8M
54M
54.2M
54.4M
54.6M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Nerve Tibial
CHDH
0.31
0.22
enet
13
0.28
3.2e-20
-4.9
6.2
7.6e-10
-0.65
0.66
0.34
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
CHDH
0.14
0.07
blup
78
0.09
1.9e-09
-4.7
5.8
5.1e-09
-0.62
0.36
0.64
FALSE
1
GTEx
Adipose Subcutaneous
CHDH
0.10
0.04
enet
12
0.08
4.0e-07
-6.9
5.6
1.7e-08
-0.57
0.06
0.94
FALSE
3
The Cancer Genome Atlas
Testicular Germ Cell Tumors
CHDH
0.11
0.01
blup
78
0.09
5.1e-04
-7.1
5.2
2.1e-07
-0.75
0.01
0.86
FALSE