Best TWAS P=2.44e-08 · Best GWAS P=4.03e-07 conditioned to 0.222
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TMEM165 | 0.09 | 0.01 | lasso | 3 | 0.03 | 1.6e-03 | -4.9 | 5.1 | 2.8e-07 | -0.87 | 0.03 | 0.96 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | SRD5A3 | 0.19 | 0.06 | enet | 21 | 0.13 | 5.9e-05 | -4.7 | -5.1 | 2.6e-07 | 0.80 | 0.03 | 0.91 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | SRD5A3-AS1 | 0.21 | 0.09 | lasso | 3 | 0.20 | 4.3e-07 | -4.7 | -5.3 | 8.9e-08 | 0.79 | 0.03 | 0.92 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | SRD5A3-AS1 | 0.19 | 0.12 | lasso | 3 | 0.14 | 9.3e-06 | -4.4 | -5.1 | 2.6e-07 | 0.70 | 0.04 | 0.83 | FALSE |
| 5 | GTEx | Stomach | SRD5A3-AS1 | 0.16 | 0.11 | lasso | 11 | 0.12 | 1.8e-06 | -5.1 | -5.2 | 1.8e-07 | 0.94 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | SRD5A3 | 0.22 | 0.14 | blup | 44 | 0.12 | 1.9e-04 | -4.7 | -5.2 | 2.0e-07 | 0.84 | 0.01 | 0.93 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CLOCK | 0.02 | 0.02 | enet | 5 | 0.02 | 1.9e-03 | -4.9 | -5.6 | 2.4e-08 | 0.77 | 0.02 | 0.82 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SRD5A3 | 0.14 | 0.07 | blup | 44 | 0.08 | 3.4e-09 | -5.1 | -5.6 | 2.6e-08 | 0.80 | 0.00 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SRD5A3 | 0.12 | 0.07 | lasso | 2 | 0.06 | 4.2e-05 | -5.0 | -5.3 | 1.3e-07 | 0.99 | 0.00 | 0.95 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SRD5A3 | 0.19 | 0.07 | blup | 44 | 0.11 | 5.5e-12 | -5.0 | -5.4 | 5.1e-08 | 0.60 | 0.00 | 0.99 | FALSE |