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chr4:151,347,355-153,373,680

Best TWAS P=3.88e-24 · Best GWAS P=3.48e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM160A1	0.04	0.04	blup	436	0.06	1.8e-07	-8.7	8.6	5.5e-18	0.80	0.58	0.42	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PET112	0.16	0.24	lasso	10	0.23	2.7e-27	-7.3	7.5	7.2e-14	0.65	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	PET112	0.21	0.16	lasso	8	0.15	5.4e-12	-7.3	7.5	7.8e-14	0.65	1.00	0.00	FALSE
4	GTEx	Artery Aorta	PET112	0.17	0.10	lasso	9	0.11	1.2e-06	-7.7	7.7	1.9e-14	0.65	0.99	0.00	FALSE
5	GTEx	Artery Coronary	PET112	0.16	0.13	lasso	11	0.14	1.7e-05	-7.4	7.3	2.0e-13	0.65	0.57	0.09	FALSE
6	GTEx	Artery Tibial	PET112	0.17	0.14	lasso	3	0.13	4.3e-10	-7.4	7.5	7.8e-14	0.67	1.00	0.00	FALSE
7	GTEx	Brain Caudate basal ganglia	PET112	0.13	0.15	lasso	3	0.12	2.7e-04	-7.4	7.4	1.1e-13	0.66	0.28	0.12	FALSE
8	GTEx	Brain Cerebellar Hemisphere	PET112	0.24	0.24	lasso	6	0.21	4.6e-06	-7.3	7.2	8.8e-13	0.64	0.56	0.14	FALSE
9	GTEx	Brain Cerebellar Hemisphere	SH3D19	0.28	0.22	lasso	5	0.20	9.3e-06	9.9	-10.1	3.9e-24	-0.97	0.02	0.97	TRUE
10	GTEx	Brain Cerebellar Hemisphere	RP11-164P12.3	0.19	0.05	enet	20	0.02	8.8e-02	9.9	7.9	2.1e-15	0.77	0.02	0.93	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RP11-164P12.4	0.47	0.44	enet	18	0.35	6.6e-10	9.8	10.0	1.6e-23	0.92	0.02	0.98	FALSE
12	GTEx	Brain Cerebellum	PET112	0.13	0.15	lasso	8	0.13	1.3e-04	-7.7	7.7	1.8e-14	0.67	0.31	0.07	FALSE
13	GTEx	Brain Cerebellum	RP11-164P12.3	0.21	0.02	enet	19	0.03	3.4e-02	9.8	7.7	1.3e-14	0.77	0.03	0.90	FALSE
14	GTEx	Brain Cerebellum	RP11-164P12.4	0.48	0.40	lasso	17	0.49	2.2e-16	-8.8	9.5	1.7e-21	0.89	0.02	0.98	FALSE
15	GTEx	Brain Cortex	PET112	0.11	0.13	enet	22	0.12	4.1e-04	-7.9	8.2	2.8e-16	0.79	0.16	0.68	FALSE
16	GTEx	Brain Frontal Cortex BA9	PET112	0.22	0.13	enet	14	0.05	1.6e-02	-8.7	7.5	4.5e-14	0.79	0.14	0.43	FALSE
17	GTEx	Breast Mammary Tissue	PET112	0.12	0.03	enet	11	0.01	1.4e-01	-7.4	9.2	2.2e-20	0.71	0.59	0.14	FALSE
18	GTEx	Breast Mammary Tissue (Female)	PET112	0.03	0.00	lasso	4	0.00	3.2e-01	-6.0	8.0	1.1e-15	0.54	0.04	0.06	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	PET112	0.26	0.20	enet	23	0.26	3.7e-09	-8.8	-7.0	3.4e-12	-0.70	0.91	0.08	FALSE
20	GTEx	Colon Sigmoid	PET112	0.13	0.08	enet	18	0.03	2.6e-02	-7.2	7.5	5.0e-14	0.72	0.20	0.56	FALSE
21	GTEx	Colon Transverse	PET112	0.16	0.18	lasso	4	0.21	3.0e-10	-7.3	5.8	7.6e-09	0.48	0.99	0.00	FALSE
22	GTEx	Esophagus Mucosa	PET112	0.07	0.10	lasso	1	0.09	1.8e-06	-7.3	7.3	2.6e-13	0.64	0.94	0.01	FALSE
23	GTEx	Esophagus Muscularis	PET112	0.13	0.12	lasso	1	0.13	3.9e-08	-7.3	7.3	2.5e-13	0.64	0.98	0.00	FALSE
24	GTEx	Heart Atrial Appendage	PET112	0.20	0.11	enet	24	0.18	2.1e-08	-9.2	8.8	1.1e-18	0.73	0.16	0.83	FALSE
25	GTEx	Heart Atrial Appendage	RP11-164P12.3	0.13	0.03	lasso	5	0.02	4.4e-02	-7.9	8.3	1.4e-16	0.71	0.13	0.52	FALSE
26	GTEx	Heart Left Ventricle	PET112	0.14	0.06	lasso	4	0.04	5.0e-03	-8.7	8.8	2.0e-18	0.81	0.23	0.27	FALSE
27	GTEx	Muscle Skeletal	PET112	0.10	0.07	lasso	5	0.07	3.6e-07	-7.3	7.2	6.9e-13	0.63	0.99	0.00	FALSE
28	GTEx	Nerve Tibial	PET112	0.13	0.10	enet	13	0.10	9.7e-08	-8.4	8.3	1.0e-16	0.77	0.99	0.01	FALSE
29	GTEx	Nerve Tibial	RP11-164P12.3	0.08	0.14	lasso	6	0.14	8.3e-10	-7.9	8.7	3.3e-18	0.78	0.94	0.06	FALSE
30	GTEx	Spleen	PET112	0.34	0.04	lasso	8	0.11	1.2e-03	-7.2	6.5	9.9e-11	0.55	0.26	0.06	FALSE
31	GTEx	Spleen	RP11-164P12.4	0.36	0.26	lasso	10	0.20	5.8e-06	9.9	9.9	5.8e-23	0.92	0.02	0.98	FALSE
32	GTEx	Thyroid	PET112	0.27	0.21	enet	38	0.22	1.1e-16	-7.3	7.0	2.3e-12	0.55	1.00	0.00	FALSE
33	NTR	Blood	FAM160A1	0.03	0.02	enet	26	0.02	1.4e-07	-8.4	9.3	1.6e-20	0.84	0.03	0.97	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	PET112	0.04	0.02	bslmm	410	0.04	5.2e-06	-8.9	9.7	3.3e-22	0.68	0.68	0.18	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PET112L	0.14	0.02	enet	12	0.04	1.1e-04	-7.2	6.5	6.4e-11	0.58	0.09	0.86	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	FAM160A1	0.04	0.02	blup	99	0.02	1.2e-05	9.9	8.6	9.5e-18	0.79	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	FAM160A1	0.06	0.05	lasso	3	0.04	1.8e-03	-8.4	9.1	8.2e-20	0.81	0.04	0.71	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	PET112L	0.05	0.02	enet	6	0.03	4.0e-04	-7.7	7.5	4.7e-14	0.68	0.07	0.87	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	PET112L	0.02	0.01	lasso	1	0.01	7.1e-02	-7.4	7.4	1.4e-13	0.66	0.07	0.27	FALSE
40	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FAM160A1	0.07	0.03	lasso	3	0.05	1.9e-04	-8.6	8.5	2.4e-17	0.78	0.06	0.90	FALSE
41	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FAM160A1	0.08	0.05	blup	99	0.05	2.9e-03	-7.9	9.3	1.9e-20	0.81	0.04	0.73	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PET112L	0.09	0.04	blup	76	0.07	1.0e-03	-7.1	8.3	1.3e-16	0.71	0.12	0.65	FALSE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PET112L	0.09	0.07	lasso	2	0.06	2.5e-03	-7.7	7.6	3.8e-14	0.66	0.08	0.28	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	FAM160A1	0.09	0.10	lasso	2	0.10	3.3e-10	9.9	10.0	1.9e-23	1.00	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	PET112L	0.04	0.03	blup	77	0.02	6.6e-03	-6.6	6.6	5.4e-11	0.54	0.10	0.14	FALSE
46	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PET112L	0.12	0.03	blup	77	0.05	8.9e-03	-7.0	5.2	1.5e-07	0.42	0.04	0.08	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	PET112L	0.13	0.08	lasso	3	0.08	1.9e-08	-7.3	7.0	2.0e-12	0.62	0.73	0.27	FALSE
48	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	FAM160A1	0.16	0.14	enet	33	0.11	6.6e-04	9.9	9.8	1.3e-22	0.88	0.02	0.97	FALSE