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chr9:106,163,708-107,600,193

Best TWAS P=1.35e-09 · Best GWAS P=3.85e-09 conditioned to 0.488

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SMC2	0.39	0.55	lasso	8	0.55	5.3e-80	5.8	5.8	6.3e-09	0.99	0.02	0.98	FALSE
2	GTEx	Brain Caudate basal ganglia	SMC2	0.20	0.24	enet	10	0.17	1.1e-05	5.8	5.8	9.2e-09	0.98	0.02	0.97	FALSE
3	GTEx	Brain Cerebellar Hemisphere	SMC2	0.35	0.36	enet	17	0.37	2.2e-10	5.4	5.6	1.9e-08	0.97	0.03	0.97	FALSE
4	GTEx	Brain Cerebellum	SMC2	0.44	0.46	lasso	6	0.49	1.6e-16	5.7	5.6	1.8e-08	0.99	0.02	0.98	FALSE
5	GTEx	Brain Cortex	SMC2	0.21	0.28	enet	7	0.20	3.8e-06	5.8	5.8	8.6e-09	0.99	0.02	0.97	FALSE
6	GTEx	Brain Frontal Cortex BA9	SMC2	0.29	0.34	enet	19	0.32	3.1e-09	5.8	5.2	1.8e-07	0.87	0.02	0.98	FALSE
7	GTEx	Brain Hypothalamus	SMC2	0.23	0.30	enet	8	0.29	1.8e-07	5.7	5.7	9.3e-09	0.99	0.02	0.96	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	SMC2	0.27	0.09	lasso	6	0.11	7.0e-04	5.4	5.3	1.3e-07	0.93	0.03	0.95	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	SMC2	0.21	0.20	enet	12	0.17	1.2e-06	5.4	5.2	1.6e-07	0.97	0.04	0.96	FALSE
10	GTEx	Esophagus Muscularis	SMC2	0.21	0.17	enet	25	0.17	1.5e-10	5.7	5.8	6.8e-09	0.93	0.03	0.97	FALSE
11	GTEx	Heart Atrial Appendage	SMC2	0.43	0.38	enet	17	0.35	1.4e-16	5.7	5.8	6.8e-09	0.99	0.02	0.98	FALSE
12	GTEx	Heart Left Ventricle	SMC2	0.32	0.29	enet	9	0.28	2.2e-15	5.8	5.9	3.9e-09	1.00	0.02	0.98	FALSE
13	GTEx	Nerve Tibial	SMC2	0.10	0.07	lasso	7	0.05	3.2e-04	5.8	5.5	4.5e-08	0.94	0.02	0.98	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	SMC2	0.12	0.07	lasso	1	0.07	1.8e-04	5.5	5.5	4.9e-08	0.95	0.04	0.94	FALSE
15	GTEx	Thyroid	SMC2	0.20	0.29	lasso	6	0.28	4.9e-22	5.3	5.6	2.6e-08	0.99	0.02	0.98	FALSE
16	METSIM	Adipose	SMC2	0.05	0.05	lasso	10	0.04	5.4e-07	5.8	5.5	4.7e-08	0.96	0.02	0.98	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMC2	0.01	0.00	blup	63	0.01	6.5e-03	5.7	-6.1	1.4e-09	-0.93	0.02	0.90	TRUE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMC2	0.09	0.06	blup	63	0.06	2.6e-07	5.8	-5.8	5.2e-09	-0.91	0.01	0.98	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMC2	0.04	0.05	lasso	2	0.04	3.9e-05	5.7	5.8	8.6e-09	1.00	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SMC2	0.04	0.01	blup	63	0.02	1.7e-03	5.7	-5.4	6.2e-08	-0.81	0.02	0.67	FALSE