[Hub]/) : Traits : Neuroticism :

chr3:48,702,606-51,043,528

Best TWAS P=1.7e-09 · Best GWAS P=4.11e-07 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous TCTA 0.05 0.01 enet 10 0.01 5.8e-02 4.3 -5.2 2.1e-07 0.07 0.06 0.39 FALSE
2 GTEx Brain Caudate basal ganglia RBM6 0.20 0.14 enet 16 0.11 5.5e-04 -4.3 -5.5 3.8e-08 -0.29 0.36 0.36 FALSE
3 GTEx Brain Cerebellum RNF123 0.36 0.31 enet 43 0.36 2.4e-11 4.2 5.1 3.9e-07 0.10 0.10 0.78 FALSE
4 GTEx Brain Cerebellum GPX1 0.31 0.09 enet 19 0.23 2.0e-07 -4.2 5.5 4.5e-08 -0.04 0.10 0.74 FALSE
5 GTEx Brain Frontal Cortex BA9 GPX1 0.16 0.06 lasso 6 0.15 7.9e-05 4.1 6.0 1.7e-09 -0.01 0.05 0.61 TRUE
6 GTEx Esophagus Muscularis GPX1 0.13 0.05 lasso 14 0.06 1.1e-04 -4.2 5.5 3.3e-08 -0.04 0.10 0.75 FALSE
7 GTEx Lung GPX1 0.04 0.02 enet 13 0.04 5.7e-04 -4.0 5.6 1.6e-08 0.00 0.06 0.39 FALSE
8 GTEx Nerve Tibial HYAL1 0.08 0.06 enet 14 0.05 3.6e-04 3.6 5.2 2.5e-07 0.60 0.06 0.78 FALSE
9 GTEx Nerve Tibial U73166.2 0.07 0.03 lasso 3 0.03 2.8e-03 5.0 -5.1 2.9e-07 -0.96 0.01 0.97 TRUE