[Hub]/) : Traits : Neuroticism :

chr3:51,860,817-53,623,102

Best TWAS P=6.95e-08 · Best GWAS P=6.56e-08 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NEK4 0.07 0.11 enet 69 0.11 1.0e-13 -4.8 5.1 3.8e-07 -0.93 0.08 0.91 FALSE
2 GTEx Adipose Visceral Omentum NEK4 0.10 0.09 lasso 3 0.08 5.0e-05 -5.1 5.1 3.0e-07 -0.87 0.09 0.90 FALSE
3 GTEx Artery Coronary TMEM110 0.17 0.05 lasso 8 0.07 3.1e-03 4.4 -5.1 3.5e-07 0.68 0.15 0.37 FALSE
4 GTEx Skin Not Sun Exposed Suprapubic NT5DC2 0.23 0.10 lasso 4 0.09 8.3e-06 -5.4 5.4 8.0e-08 -1.00 0.02 0.98 FALSE
5 GTEx Skin Sun Exposed Lower leg NT5DC2 0.21 0.19 enet 12 0.18 2.0e-14 -5.4 5.4 6.9e-08 -0.99 0.02 0.98 TRUE
6 GTEx Testis GNL3 0.12 0.18 lasso 7 0.18 2.4e-08 -4.9 5.1 3.3e-07 -0.86 0.10 0.90 FALSE
7 GTEx Thyroid PBRM1 0.19 0.33 lasso 7 0.31 2.7e-24 -5.0 -5.1 3.7e-07 0.90 0.10 0.90 FALSE