[Hub]/) : Traits : Neuroticism :

chr3:135,273,949-137,423,165

Best TWAS P=5.23e-12 · Best GWAS P=2.98e-12 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PCCB 0.09 0.19 lasso 7 0.18 1.2e-21 -7.0 -6.9 5.2e-12 0.98 0.02 0.98 TRUE
2 GTEx Adipose Subcutaneous PCCB 0.07 0.05 enet 4 0.02 6.6e-03 5.6 -5.7 1.5e-08 0.75 0.07 0.84 FALSE
3 GTEx Adrenal Gland PCCB 0.17 0.09 lasso 6 0.10 2.1e-04 -6.9 -5.8 7.3e-09 0.94 0.03 0.93 FALSE
4 GTEx Artery Coronary RP11-85F14.5 0.15 0.01 lasso 4 0.00 2.3e-01 -6.9 -6.8 7.5e-12 0.91 0.03 0.81 FALSE
5 GTEx Artery Tibial PCCB 0.05 0.02 lasso 5 0.02 1.7e-02 -6.4 -5.8 5.1e-09 0.91 0.04 0.95 FALSE
6 GTEx Brain Caudate basal ganglia PCCB 0.11 0.01 enet 12 0.01 2.1e-01 -6.6 -6.6 3.9e-11 0.79 0.04 0.51 FALSE
7 GTEx Brain Frontal Cortex BA9 PCCB 0.11 0.01 enet 9 0.01 1.7e-01 5.6 -5.7 9.8e-09 0.82 0.05 0.60 FALSE
8 GTEx Breast Mammary Tissue PCCB 0.08 0.05 lasso 3 0.03 1.3e-02 5.6 -6.0 1.9e-09 0.79 0.07 0.76 FALSE
9 GTEx Cells EBV-transformed lymphocytes PCCB 0.11 0.10 lasso 3 0.11 2.3e-04 -3.5 -5.4 6.7e-08 0.73 0.04 0.87 FALSE
10 GTEx Cells Transformed fibroblasts PCCB 0.10 0.09 lasso 3 0.07 5.0e-06 -6.7 -6.5 6.0e-11 0.95 0.04 0.96 FALSE
11 GTEx Colon Transverse PCCB 0.07 0.06 lasso 3 0.04 7.7e-03 -6.7 -6.3 2.2e-10 0.92 0.04 0.91 FALSE
12 GTEx Esophagus Mucosa PCCB 0.10 0.12 lasso 3 0.11 4.8e-08 -6.9 -6.8 1.1e-11 0.95 0.02 0.98 FALSE
13 GTEx Heart Left Ventricle PCCB 0.08 0.05 enet 7 0.01 7.2e-02 -6.4 -6.6 4.7e-11 0.91 0.03 0.96 FALSE
14 GTEx Lung PCCB 0.07 0.04 lasso 3 0.03 4.2e-03 -6.7 -6.8 7.9e-12 0.91 0.04 0.90 FALSE
15 GTEx Muscle Skeletal PCCB 0.09 0.09 enet 13 0.11 1.2e-10 -6.9 -6.6 5.0e-11 0.91 0.02 0.98 FALSE
16 GTEx Skin Not Sun Exposed Suprapubic IL20RB 0.22 0.16 lasso 9 0.19 1.2e-10 5.5 5.3 9.0e-08 -0.55 1.00 0.00 FALSE
17 GTEx Testis PCCB 0.26 0.22 lasso 10 0.22 4.7e-10 -6.9 -6.8 1.3e-11 0.96 0.02 0.98 FALSE
18 GTEx Thyroid PCCB 0.10 0.09 lasso 6 0.09 1.3e-07 -6.5 -6.0 2.2e-09 0.86 0.07 0.93 FALSE
19 METSIM Adipose PCCB 0.07 0.06 lasso 12 0.06 4.1e-09 -6.9 -6.2 5.9e-10 0.93 0.02 0.98 FALSE
20 ROSMAP Brain Pre-frontal Cortex PCCB 0.10 0.07 lasso 4 0.10 4.2e-13 -6.9 -5.8 7.0e-09 0.85 0.03 0.97 FALSE
21 YFS Blood PCCB 0.13 0.20 lasso 9 0.20 1.3e-64 -6.9 -6.9 6.0e-12 0.97 0.02 0.98 FALSE
22 TCGA Ovarian Tumor PCCB 0.03 0.01 blup 251 0.01 6.2e-02 -6.4 -5.6 2.3e-08 0.92 0.04 0.86 FALSE
23 TCGA Ovarian Tumor RP11-102M11.2 0.08 0.04 blup 308 0.09 5.0e-09 -5.3 -6.0 2.5e-09 0.84 0.05 0.95 FALSE