[Hub]/) : Traits : Neuroticism :

chr9:126,946,822-128,824,378

Best TWAS P=1.19e-08 · Best GWAS P=2.82e-08 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial PRPS1P2 0.06 0.06 enet 6 0.05 9.2e-05 -5.5 -5.5 3.6e-08 1.00 0.03 0.97 FALSE
2 GTEx Breast Mammary Tissue (Male) PPP6C 0.12 0.03 enet 12 0.03 6.5e-02 -5.5 5.4 5.7e-08 -0.99 0.03 0.62 FALSE
3 GTEx Breast Mammary Tissue (Female) PPP6C 0.14 0.04 lasso 4 0.04 3.1e-02 -5.6 5.7 1.2e-08 -0.97 0.04 0.89 TRUE
4 GTEx Cells EBV-transformed lymphocytes GOLGA1 0.13 0.00 enet 8 0.06 3.8e-03 -5.3 -5.5 4.5e-08 0.88 0.04 0.89 FALSE
5 GTEx Cells Transformed fibroblasts PRPS1P2 0.09 0.11 enet 8 0.13 9.6e-10 -5.3 -5.5 3.2e-08 0.97 0.04 0.96 FALSE
6 GTEx Colon Transverse PRPS1P2 0.11 0.10 lasso 1 0.08 1.8e-04 -5.3 -5.3 1.4e-07 0.95 0.03 0.95 FALSE
7 GTEx Esophagus Mucosa PPP6C 0.07 0.07 enet 21 0.08 7.1e-06 -5.5 5.4 5.9e-08 -0.87 0.03 0.97 FALSE
8 GTEx Esophagus Mucosa PRPS1P2 0.07 0.08 lasso 3 0.07 1.5e-05 -5.5 -5.3 1.2e-07 0.99 0.03 0.97 FALSE
9 GTEx Muscle Skeletal PPP6C 0.03 0.03 enet 6 0.01 3.0e-02 -5.2 5.2 2.1e-07 -0.97 0.04 0.93 FALSE
10 GTEx Nerve Tibial GAPVD1 0.17 0.08 lasso 10 0.10 9.3e-08 -5.5 5.6 2.2e-08 -0.87 0.04 0.96 FALSE
11 GTEx Pancreas PRPS1P2 0.16 0.13 lasso 6 0.12 8.7e-06 -5.5 -5.5 4.2e-08 0.99 0.03 0.97 FALSE
12 GTEx Thyroid PRPS1P2 0.08 0.09 enet 18 0.07 4.0e-06 -5.5 -5.3 1.5e-07 0.97 0.03 0.97 FALSE
13 TCGA Prostate Tumor PPP6C 0.07 0.06 lasso 2 0.06 3.8e-08 -5.3 5.3 9.5e-08 -0.96 0.04 0.96 FALSE