[Hub]/) : Traits : Neuroticism :

chr11:46,010,847-48,559,571

Best TWAS P=2.62e-13 · Best GWAS P=6.69e-11 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LRP4 0.04 0.05 lasso 4 0.04 6.6e-06 -5.7 -6.2 4.5e-10 -0.34 0.14 0.86 TRUE
2 CommonMind Brain Pre-frontal Cortex MTCH2 0.03 0.00 bslmm 299 0.00 1.1e-01 3.3 -5.7 1.2e-08 -0.27 0.04 0.70 FALSE
3 GTEx Adipose Subcutaneous C1QTNF4 0.16 0.22 lasso 4 0.22 2.5e-18 -4.4 5.1 3.2e-07 0.36 0.44 0.56 FALSE
4 GTEx Adipose Subcutaneous ARHGAP1 0.08 0.03 lasso 6 0.05 3.4e-05 -5.7 5.8 6.4e-09 0.39 0.04 0.95 TRUE
5 GTEx Artery Aorta CKAP5 0.09 0.12 lasso 1 0.07 1.2e-04 -5.4 -5.4 6.2e-08 -0.23 0.42 0.56 FALSE
6 GTEx Artery Tibial LRP4 0.06 0.00 lasso 5 0.00 6.4e-01 5.0 5.6 1.9e-08 0.32 0.05 0.18 FALSE
7 GTEx Artery Tibial ZNF408 0.10 0.00 lasso 6 0.04 2.0e-04 -4.6 6.7 1.8e-11 0.49 0.10 0.73 FALSE
8 GTEx Brain Cerebellar Hemisphere RP11-750H9.5 0.17 0.25 lasso 6 0.21 3.5e-06 5.1 -5.1 3.2e-07 -0.70 0.38 0.18 FALSE
9 GTEx Brain Cortex MTCH2 0.21 0.19 lasso 6 0.16 4.0e-05 -6.2 -5.8 6.1e-09 -0.28 0.03 0.93 FALSE
10 GTEx Brain Cortex C1QTNF4 0.26 0.04 lasso 8 0.02 1.2e-01 4.9 6.0 1.8e-09 0.56 0.04 0.34 FALSE
11 GTEx Breast Mammary Tissue C1QTNF4 0.10 0.06 lasso 2 0.03 8.5e-03 -5.2 5.2 2.6e-07 0.32 0.05 0.84 FALSE
12 GTEx Breast Mammary Tissue ARHGAP1 0.05 0.00 enet 14 0.01 1.3e-01 -4.6 5.9 2.8e-09 0.44 0.07 0.51 FALSE
13 GTEx Breast Mammary Tissue (Female) MADD 0.13 0.04 lasso 3 0.05 1.3e-02 -5.3 -5.6 2.5e-08 -0.40 0.04 0.43 FALSE
14 GTEx Cells Transformed fibroblasts FNBP4 0.11 0.05 lasso 8 0.08 1.6e-06 4.9 -5.7 1.5e-08 -0.48 0.36 0.64 FALSE
15 GTEx Colon Transverse C1QTNF4 0.07 0.02 lasso 6 0.03 2.0e-02 -4.4 5.3 8.8e-08 0.34 0.04 0.86 FALSE
16 GTEx Esophagus Gastroesophageal Junction NUP160 0.18 0.02 enet 18 0.11 7.1e-05 3.9 -6.6 3.1e-11 -0.60 0.14 0.49 FALSE
17 GTEx Esophagus Muscularis MTCH2 0.09 0.04 lasso 6 0.02 1.8e-02 -6.3 -6.8 7.6e-12 -0.57 0.02 0.96 FALSE
18 GTEx Esophagus Muscularis CKAP5 0.05 0.03 lasso 4 0.04 3.3e-03 -5.4 -5.8 6.9e-09 -0.26 0.16 0.64 FALSE
19 GTEx Esophagus Muscularis ARHGAP1 0.07 0.08 lasso 3 0.07 6.1e-05 -5.4 5.4 5.3e-08 0.26 0.12 0.87 FALSE
20 GTEx Heart Atrial Appendage C1QTNF4 0.26 0.14 lasso 9 0.17 3.9e-08 -4.3 5.1 2.7e-07 0.38 0.08 0.92 FALSE
21 GTEx Liver C1QTNF4 0.25 0.14 enet 16 0.20 2.3e-06 -4.3 5.8 7.9e-09 0.58 0.05 0.92 TRUE
22 GTEx Lung C1QTNF4 0.18 0.15 lasso 6 0.13 3.2e-10 -5.2 5.5 2.9e-08 0.36 0.03 0.97 FALSE
23 GTEx Ovary ARHGAP1 0.25 0.09 lasso 16 0.18 3.8e-05 -3.6 5.3 1.1e-07 0.31 0.13 0.56 FALSE
24 GTEx Pituitary MADD 0.42 0.32 lasso 6 0.39 8.9e-11 6.5 -7.3 2.6e-13 -0.89 0.01 0.99 TRUE
25 GTEx Prostate CELF1 0.17 0.16 lasso 2 0.12 6.2e-04 -5.9 -5.9 4.9e-09 -0.29 0.14 0.31 FALSE
26 GTEx Prostate ZNF408 0.19 0.10 lasso 2 0.10 1.6e-03 -5.8 5.7 9.6e-09 0.28 0.03 0.79 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic C1QTNF4 0.32 0.18 enet 33 0.20 5.2e-11 -4.3 5.3 1.2e-07 0.31 0.06 0.94 FALSE
28 GTEx Skin Not Sun Exposed Suprapubic ARHGAP1 0.06 0.01 lasso 9 0.00 2.8e-01 -5.8 5.7 1.6e-08 0.32 0.04 0.76 FALSE
29 GTEx Skin Sun Exposed Lower leg DDB2 0.08 0.10 lasso 4 0.10 5.8e-09 -5.0 -5.7 1.2e-08 -0.36 0.54 0.46 FALSE
30 GTEx Skin Sun Exposed Lower leg C1QTNF4 0.25 0.22 lasso 12 0.23 4.2e-19 -4.3 5.7 9.0e-09 0.47 0.05 0.95 FALSE
31 GTEx Spleen C1QTNF4 0.31 0.28 enet 29 0.34 1.8e-09 -6.2 6.1 7.9e-10 0.46 0.02 0.97 TRUE
32 GTEx Testis MTCH2 0.17 0.16 lasso 3 0.16 1.0e-07 -5.2 -5.2 2.0e-07 -0.34 0.06 0.94 TRUE
33 GTEx Testis C1QTNF4 0.14 0.12 lasso 4 0.11 1.6e-05 5.1 6.0 1.9e-09 0.54 0.68 0.19 FALSE
34 GTEx Whole Blood C1QTNF4 0.09 0.05 lasso 3 0.03 1.4e-03 -6.1 6.1 8.7e-10 0.35 0.02 0.97 FALSE
35 METSIM Adipose C1QTNF4 0.24 0.31 lasso 7 0.31 1.2e-46 -6.3 6.2 6.5e-10 0.34 0.01 0.99 FALSE
36 METSIM Adipose DDB2 0.03 0.03 lasso 2 0.02 1.9e-04 -5.4 5.6 2.1e-08 0.25 0.28 0.66 FALSE
37 METSIM Adipose NR1H3 0.03 0.03 lasso 6 0.04 4.7e-06 5.0 -6.1 1.0e-09 -0.85 0.05 0.93 FALSE
38 NTR Blood MTCH2 0.02 0.04 lasso 1 0.04 1.3e-11 -6.3 6.3 2.4e-10 0.37 0.01 0.99 FALSE
39 ROSMAP Brain Pre-frontal Cortex MTCH2 0.35 0.40 enet 9 0.40 4.7e-56 -6.3 -6.2 6.5e-10 -0.37 0.01 0.99 FALSE
40 ROSMAP Brain Pre-frontal Cortex FNBP4 0.04 0.04 lasso 3 0.04 8.2e-06 5.1 -5.6 2.3e-08 -0.63 0.89 0.11 FALSE
41 ROSMAP Brain Pre-frontal Cortex DDB2 0.04 0.03 enet 15 0.03 7.1e-05 -5.8 5.3 1.0e-07 0.20 0.25 0.73 FALSE
42 TCGA Breast Normal ARHGAP1 0.02 0.00 blup 247 0.02 3.8e-05 -4.6 5.2 1.9e-07 0.23 0.20 0.49 FALSE
43 TCGA Prostate Tumor ZNF408 0.02 0.02 enet 3 0.02 7.5e-04 -4.7 5.7 1.4e-08 0.35 0.03 0.22 FALSE