[Hub]/) : Traits : Neuroticism :

chr11:56,666,189-58,178,587

Best TWAS P=4.03e-12 · Best GWAS P=6.05e-12 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Breast Mammary Tissue MED19 0.11 0.04 enet 26 0.10 7.5e-06 6.6 -5.9 3.3e-09 -0.77 0.02 0.93 FALSE
2 GTEx Esophagus Mucosa MED19 0.14 0.07 lasso 4 0.11 5.9e-08 3.1 -5.7 1.5e-08 -0.80 0.02 0.98 FALSE
3 GTEx Heart Atrial Appendage MED19 0.11 0.14 lasso 1 0.14 6.0e-07 6.6 -6.6 3.2e-11 -0.96 0.02 0.98 FALSE
4 GTEx Pancreas MED19 0.10 0.08 lasso 3 0.02 5.0e-02 6.8 -6.8 1.4e-11 -0.98 0.02 0.89 FALSE
5 GTEx Skin Sun Exposed Lower leg ZDHHC5 0.05 0.03 lasso 8 0.02 6.2e-03 6.5 6.7 2.8e-11 0.91 0.05 0.93 FALSE
6 GTEx Skin Sun Exposed Lower leg MED19 0.15 0.11 lasso 7 0.09 1.3e-07 6.8 -6.8 1.1e-11 -0.97 0.01 0.99 FALSE
7 GTEx Stomach MED19 0.10 0.04 lasso 7 0.09 6.8e-05 6.5 -5.9 3.1e-09 -0.89 0.03 0.89 FALSE
8 NTR Blood SERPING1 0.01 0.00 blup 399 0.00 2.9e-02 -4.6 5.4 6.8e-08 0.69 0.08 0.76 FALSE
9 ROSMAP Brain Pre-frontal Cortex ZDHHC5 0.05 0.02 blup 401 0.03 2.0e-04 6.8 -6.7 1.5e-11 -0.78 0.01 0.96 FALSE
10 YFS Blood ZDHHC5 0.06 0.07 enet 20 0.07 1.2e-22 6.6 6.9 4.0e-12 0.96 0.01 0.99 TRUE