[Hub]/) : Traits : Neuroticism :

chr11:112,135,760-113,969,669

Best TWAS P=1.09e-17 · Best GWAS P=2.54e-19 conditioned to 1.33e-11

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Caudate basal ganglia TTC12 0.57 0.20 lasso 9 0.38 4.4e-12 3.1 5.5 5.0e-08 -0.09 0.97 0.00 FALSE
2 GTEx Brain Caudate basal ganglia RP11-159N11.4 0.32 0.07 lasso 7 0.14 9.7e-05 3.4 5.9 3.5e-09 -0.14 0.46 0.06 FALSE
3 GTEx Brain Cortex TTC12 0.48 0.39 lasso 5 0.43 3.2e-13 5.4 5.4 6.8e-08 -0.05 0.96 0.00 FALSE
4 GTEx Brain Hypothalamus RP11-159N11.4 0.44 0.06 lasso 19 0.03 7.5e-02 5.4 6.9 5.8e-12 -0.07 0.13 0.08 FALSE
5 GTEx Breast Mammary Tissue TTC12 0.46 0.30 lasso 7 0.40 8.1e-22 5.4 6.0 1.5e-09 -0.09 1.00 0.00 FALSE
6 GTEx Breast Mammary Tissue (Female) TTC12 0.46 0.22 lasso 10 0.34 6.2e-11 -6.4 5.5 4.9e-08 -0.06 0.97 0.00 FALSE
7 GTEx Esophagus Gastroesophageal Junction TTC12 0.67 0.39 enet 34 0.54 4.6e-23 -5.8 5.6 1.6e-08 -0.07 1.00 0.00 FALSE
8 GTEx Heart Left Ventricle TTC12 0.39 0.24 enet 36 0.38 2.5e-21 7.6 7.0 2.0e-12 -0.17 1.00 0.00 FALSE
9 GTEx Muscle Skeletal TTC12 0.44 0.34 lasso 10 0.40 2.4e-41 -6.3 5.2 2.2e-07 -0.08 1.00 0.00 FALSE
10 GTEx Skin Not Sun Exposed Suprapubic TTC12 0.49 0.29 lasso 10 0.51 6.5e-32 5.4 5.6 2.2e-08 -0.09 1.00 0.00 FALSE
11 GTEx Spleen RP11-159N11.4 0.30 0.06 lasso 6 0.06 1.4e-02 7.3 6.3 3.0e-10 -0.07 0.14 0.05 FALSE
12 GTEx Testis TTC12 0.42 0.16 enet 33 0.38 7.7e-18 7.4 7.8 4.4e-15 -0.35 0.85 0.13 FALSE
13 GTEx Uterus NCAM1 0.41 -0.01 lasso 11 -0.01 5.9e-01 5.4 7.4 1.6e-13 -0.15 0.08 0.07 TRUE
14 METSIM Adipose ANKK1 0.16 0.11 enet 13 0.16 9.8e-23 -5.7 -8.6 1.1e-17 0.27 1.00 0.00 TRUE
15 YFS Blood ANKK1 0.04 0.03 lasso 3 0.03 2.9e-09 -6.1 -7.2 4.9e-13 0.23 1.00 0.00 FALSE
16 TCGA Prostate Tumor TTC12 0.14 0.16 enet 13 0.16 1.6e-19 7.6 7.4 1.4e-13 -0.18 1.00 0.00 FALSE