[Hub]/) : Traits : Neuroticism :

chr12:108,763,672-110,729,807

Best TWAS P=2.04e-12 · Best GWAS P=1.91e-12 conditioned to 0.129

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MMAB 0.12 0.09 enet 13 0.08 2.9e-10 6.8 -6.5 5.8e-11 -0.69 0.04 0.96 FALSE
2 GTEx Adipose Visceral Omentum MMAB 0.10 -0.01 lasso 4 0.00 3.8e-01 -5.7 -5.6 2.8e-08 -0.57 0.10 0.23 FALSE
3 GTEx Cells Transformed fibroblasts MMAB 0.07 0.06 enet 9 0.05 7.3e-05 6.6 -7.0 2.0e-12 -0.91 0.01 0.98 TRUE
4 GTEx Colon Sigmoid KCTD10 0.25 0.16 lasso 8 0.15 6.2e-06 6.7 -6.2 4.8e-10 -0.63 0.25 0.69 FALSE
5 GTEx Colon Transverse KCTD10 0.22 0.12 lasso 11 0.13 1.1e-06 -5.8 -6.5 6.3e-11 -0.72 0.30 0.69 FALSE
6 GTEx Colon Transverse MMAB 0.08 0.07 lasso 2 0.05 1.7e-03 6.7 -6.4 1.2e-10 -0.69 0.17 0.60 FALSE
7 GTEx Muscle Skeletal MMAB 0.06 0.04 lasso 11 0.05 1.9e-05 5.5 -5.5 3.7e-08 -0.66 0.54 0.41 FALSE
8 GTEx Nerve Tibial USP30 0.07 0.01 lasso 4 0.01 1.1e-01 4.9 6.2 5.9e-10 0.81 0.04 0.78 FALSE
9 GTEx Thyroid KCTD10 0.06 0.02 enet 12 0.02 9.2e-03 7.0 -5.9 4.2e-09 -0.85 0.01 0.97 FALSE
10 GTEx Thyroid MMAB 0.07 0.00 lasso 6 0.02 5.4e-03 -5.7 -6.5 5.8e-11 -0.77 0.09 0.78 FALSE
11 GTEx Whole Blood MVK 0.05 0.00 enet 13 0.00 4.8e-01 -5.5 -5.3 1.2e-07 -0.53 0.14 0.06 FALSE
12 YFS Blood KCTD10 0.49 0.58 enet 47 0.62 1.1e-266 5.5 5.5 3.0e-08 0.74 0.99 0.01 FALSE
13 TCGA Breast Tumor MYO1H 0.55 0.19 blup 423 0.27 5.1e-07 5.2 6.2 5.7e-10 0.69 0.03 0.97 FALSE
14 TCGA Ovarian Tumor MMAB 0.07 0.02 blup 71 0.04 8.2e-05 6.7 -5.4 5.6e-08 -0.65 0.00 0.85 FALSE