[Hub]/) : Traits : Neuroticism :

chr14:74,245,607-76,226,003

Best TWAS P=7.46e-16 · Best GWAS P=1.19e-14 conditioned to 0.00961

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DLST 0.09 0.11 lasso 2 0.11 4.0e-13 -7.3 7.6 3.8e-14 -0.74 0.06 0.94 FALSE
2 CommonMind Brain Pre-frontal Cortex RPS6KL1 0.04 0.02 lasso 5 0.02 4.8e-04 4.8 -6.4 1.4e-10 0.61 0.14 0.60 FALSE
3 GTEx Adipose Subcutaneous YLPM1 0.10 0.03 lasso 6 0.02 7.9e-03 -7.2 7.7 1.7e-14 -0.58 0.07 0.52 FALSE
4 GTEx Adipose Visceral Omentum RPS6KL1 0.12 0.09 lasso 2 0.08 3.7e-05 4.8 5.1 3.8e-07 -0.48 0.44 0.49 FALSE
5 GTEx Adrenal Gland RPS6KL1 0.21 0.13 enet 25 0.15 4.4e-06 5.2 5.6 1.6e-08 -0.57 0.32 0.60 FALSE
6 GTEx Cells Transformed fibroblasts RPS6KL1 0.16 0.15 enet 12 0.15 2.8e-11 4.8 5.1 3.5e-07 -0.64 0.98 0.02 FALSE
7 GTEx Colon Sigmoid MLH3 0.17 0.02 enet 9 0.00 2.4e-01 -1.4 -6.1 9.7e-10 0.23 0.06 0.45 FALSE
8 GTEx Esophagus Muscularis RPS6KL1 0.10 0.11 lasso 2 0.09 3.1e-06 5.2 5.1 4.1e-07 -0.62 0.60 0.37 FALSE
9 GTEx Lung RPS6KL1 0.09 0.09 enet 24 0.08 1.8e-06 4.8 5.6 2.5e-08 -0.60 0.46 0.52 FALSE
10 GTEx Muscle Skeletal DLST 0.28 0.26 enet 23 0.26 2.1e-25 -7.5 -7.7 1.7e-14 0.34 0.04 0.96 FALSE
11 GTEx Nerve Tibial YLPM1 0.08 0.06 lasso 1 0.04 5.1e-04 5.7 5.7 1.1e-08 -0.67 0.08 0.75 FALSE
12 GTEx Nerve Tibial RPS6KL1 0.17 0.24 lasso 6 0.19 2.3e-13 4.9 5.4 5.1e-08 -0.59 1.00 0.00 FALSE
13 GTEx Prostate RPS6KL1 0.26 0.10 lasso 3 0.17 4.6e-05 5.7 5.1 3.0e-07 -0.65 0.07 0.81 FALSE
14 GTEx Skin Not Sun Exposed Suprapubic RPS6KL1 0.08 0.08 enet 11 0.07 1.5e-04 7.4 8.1 7.5e-16 -0.74 0.06 0.93 TRUE
15 GTEx Skin Sun Exposed Lower leg RPS6KL1 0.15 0.13 lasso 4 0.12 1.8e-10 4.8 5.5 3.1e-08 -0.68 0.76 0.24 FALSE
16 GTEx Spleen NPC2 0.30 0.08 enet 10 0.06 1.5e-02 6.2 5.9 3.4e-09 -0.77 0.12 0.37 FALSE
17 GTEx Stomach RPS6KL1 0.09 -0.01 enet 16 0.00 3.3e-01 -4.0 5.4 6.6e-08 -0.30 0.05 0.64 FALSE
18 GTEx Testis AREL1 0.20 0.14 enet 34 0.13 2.1e-06 7.3 7.9 2.0e-15 -0.78 0.06 0.93 FALSE
19 METSIM Adipose ACYP1 0.03 0.02 blup 413 0.02 4.0e-04 -2.6 5.4 7.0e-08 -0.51 0.68 0.26 FALSE
20 METSIM Adipose YLPM1 0.04 0.00 bslmm 380 0.01 2.7e-03 -1.7 5.1 3.4e-07 -0.47 0.07 0.29 FALSE
21 TCGA Breast Normal RPS6KL1 0.04 0.02 enet 4 0.02 1.6e-05 -7.2 6.7 2.3e-11 -0.69 0.14 0.76 FALSE