[Hub]/) : Traits : Neuroticism :

chr15:66,850,204-68,789,191

Best TWAS P=1.78e-08 · Best GWAS P=7.06e-09 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous MAP2K5 0.14 0.18 lasso 4 0.18 1.0e-14 5.1 -5.2 2.1e-07 -0.95 0.02 0.98 FALSE
2 GTEx Adipose Visceral Omentum MAP2K5 0.07 0.08 lasso 3 0.05 1.0e-03 5.6 -5.6 1.8e-08 -0.96 0.01 0.98 TRUE
3 GTEx Artery Aorta MAP2K5 0.06 0.05 enet 6 0.05 7.7e-04 5.1 -5.3 1.3e-07 -0.92 0.02 0.97 FALSE
4 GTEx Artery Tibial MAP2K5 0.15 0.18 lasso 3 0.18 6.3e-14 5.2 -5.4 6.5e-08 -0.95 0.02 0.98 FALSE
5 GTEx Brain Cerebellum MAP2K5 0.27 0.12 lasso 5 0.14 7.9e-05 4.9 -5.2 2.4e-07 -0.87 0.08 0.84 FALSE
6 GTEx Breast Mammary Tissue MAP2K5 0.14 0.07 lasso 5 0.09 2.8e-05 4.6 -5.5 4.0e-08 -0.86 0.03 0.96 FALSE
7 GTEx Esophagus Muscularis MAP2K5 0.24 0.14 lasso 4 0.13 2.1e-08 5.1 -5.2 1.6e-07 -0.95 0.01 0.99 FALSE
8 GTEx Heart Atrial Appendage MAP2K5 0.16 0.08 lasso 5 0.16 1.3e-07 5.1 -5.3 9.8e-08 -0.87 0.02 0.97 FALSE
9 GTEx Heart Left Ventricle MAP2K5 0.10 0.10 lasso 3 0.10 9.4e-06 5.1 -5.1 2.8e-07 -0.94 0.01 0.99 FALSE
10 GTEx Nerve Tibial MAP2K5 0.19 0.21 lasso 2 0.20 3.3e-14 5.2 -5.2 2.5e-07 -0.94 0.04 0.96 FALSE
11 GTEx Ovary MAP2K5 0.19 0.24 lasso 3 0.21 8.3e-06 5.1 -5.3 9.9e-08 -0.94 0.02 0.95 FALSE
12 GTEx Skin Sun Exposed Lower leg MAP2K5 0.13 0.06 lasso 4 0.09 4.4e-08 -3.9 -5.2 2.2e-07 -0.80 0.14 0.86 FALSE
13 GTEx Thyroid MAP2K5 0.11 0.16 lasso 4 0.15 9.6e-12 5.1 -5.1 2.9e-07 -0.94 0.02 0.98 FALSE
14 GTEx Whole Blood MAP2K5 0.09 0.06 lasso 6 0.06 8.1e-06 5.2 -5.1 2.6e-07 -0.90 0.03 0.97 FALSE
15 NTR Blood MAP2K5 0.02 0.00 enet 13 0.01 5.7e-04 5.8 -5.3 9.9e-08 -0.87 0.00 0.99 FALSE
16 TCGA Breast Normal IQCH 0.04 0.02 enet 11 0.03 1.5e-09 4.8 -5.2 2.5e-07 -0.71 0.22 0.78 FALSE